Results 41 to 50 of about 29,072 (277)

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Targeting the ATF6-mediated ER stress response and autophagy blocks integrin-driven prostate cancer progression.

Molecular Cancer Research, 2023
Prostate cancer (PCa) progression to the lethal metastatic castration-resistant phenotype (mCRPC) is driven by αv integrins and is associated with Golgi disorganization and activation of the ATF6 branch of unfolded protein response (UPR).
Amanda J Macke, Artem N Pachikov, T. Divita, M. E. Morris, Chad A. LaGrange, Melissa S Holzapfel, A. Kubyshkin, Evgeniya Y Zyablitskaya, T. Makalish, S. N. Eremenko, Haowen Qiu, Jean‐Jack Riethoven, G. Hemstreet, A. Petrosyan   +13 more
semanticscholar   +1 more source

VAPB interacts with and modulates the activity of ATF6 [PDF]

Human Molecular Genetics, 2008
A mis-sense point mutation in the human VAPB gene is associated with a familial form of motor neuron disease that has been classified as Amyotrophic Lateral Sclerosis type VIII. Affected individuals suffer from a spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) or an atypical slowly progressing form of ALS. Mammals have two homologous
Gkogkas, C., Middleton, S., Kremer, A. M., Wardrope, C., Hannah, M., Gillingwater, T. H., Skehel, P.   +6 more
openaire   +4 more sources

Proteostasis and Beyond: ATF6 in Ischemic Disease [PDF]

Trends in Molecular Medicine, 2019
Endoplasmic reticulum (ER) stress is a pathological hallmark of numerous ischemic diseases, including stroke and myocardial infarction (MI). In these diseases, ER stress leads to activation of the unfolded protein response (UPR) and subsequent adaptation of cellular physiology in ways that dictate cellular fate following ischemia.
Christopher C. Glembotski, Jessica D. Rosarda, R. Luke Wiseman   +2 more
openaire   +2 more sources

Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

Disease Models & Mechanisms, 2020
Induction of endoplasmic reticulum (ER) stress is associated with diverse developmental and degenerative diseases. Modified ER homeostasis causes activation of conserved stress pathways at the ER called the unfolded protein response (UPR).
Eric M. Clark, Hannah J. T. Nonarath, Jonathan R. Bostrom, Brian A. Link   +3 more
doaj   +1 more source

ATF6 aggravates apoptosis in early porcine embryonic development by regulating organelle homeostasis under high-temperature conditions

Zoological Research, 2023
Activating transcription factor 6 (ATF6), one of the three sensor proteins in the endoplasmic reticulum (ER), is an important regulator of ER stress-induced apoptosis.
Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Dongjie Zhou, Zhi Chen, X. Cui   +7 more
semanticscholar   +1 more source

Interaction of ATF6 and serum response factor [PDF]

Molecular and Cellular Biology, 1997
Serum response factor (SRF) is a transcription factor which binds to the serum response element (SRE) in the c-fos promoter. It is required for regulated expression of the c-fos gene as well as other immediate-early genes and some tissue-specific genes. To better understand the regulation of SRF, we used a yeast interaction assay to screen a human HeLa
Cheng Zhu, Ron Prywes, Finn-Eirik Johansen   +2 more
openaire   +3 more sources

Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats

Frontiers in Surgery, 2021
Background: Normothermic machine perfusion (NMP) could be beneficial for organ retrieval from donors after cardiac death (DCD). Activating transcription factor 6 (ATF6) was recently shown to mitigate liver ischemia/reperfusion injury and confer ...
Nuo Cheng, Ji-Hua Shi, Yang Jin, Yuan-Bin Shi, Xu-Dong Liu, Hua-Peng Zhang, Sheng-Li Cao, Han Yang, Wen-Zhi Guo, Shui-Jun Zhang   +9 more
doaj   +1 more source

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor showing Golgi-localized mutant KIT

Cell Death and Differentiation, 2023
Gastrointestinal stromal tumors (GISTs) frequently show KIT mutations, accompanied by overexpression and aberrant localization of mutant KIT (MT-KIT).
Yujin Kwon, Jiyoon Kim, Su-Yeon Cho, Yoon Jin Kang, Jongsoo Lee, Jaeyoung Kwon, Hyungjin Rhee, Sebastian Bauer, Hyung-Sik Kim, Esak Lee, Han Sang Kim, Jae Hung Jung, Hoguen Kim, W. Kim   +13 more
semanticscholar   +1 more source

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. [PDF]

PLoS Genetics, 2014
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR).
Deanna L Howarth, Claudia Lindtner, Ana M Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C Sadler   +7 more
doaj   +1 more source