Results 41 to 50 of about 28,738 (248)

Transcriptional Factor ATF6 is Involved in Odontoblastic Differentiation [PDF]

Journal of Dental Research, 2014
ATF6 is an endoplasmic reticulum (ER) membrane-bound transcription factor that regulates various cellular functions. The purpose of this study was to investigate the role of ATF6 in odontoblast differentiation. Rat tooth germs were isolated, changes in gene expression were evaluated over time, and localization of ATF6 was determined by ...
J W, Kim, H, Choi, B C, Jeong, S H, Oh, S W, Hur, B N, Lee, S H, Kim, J E, Nör, J T, Koh, Y C, Hwang   +9 more
openaire   +2 more sources

ATF6 is essential for human cone photoreceptor development

Proceedings of the National Academy of Sciences, 2021
Significance Inactivating genetic variants in the Unfolded Protein Response (UPR) regulator Activating Transcription Factor 6 (ATF6) result in loss of color vision, which is linked to dysfunctional cone photoreceptors and the development of achromatopsia. The pathomechanims involving the lack of functional
Heike Kroeger, Julia M. D. Grandjean, Wei-Chieh Jerry Chiang, Daphne D. Bindels, Rebecca Mastey, Jennifer Okalova, Amanda Nguyen, Evan T. Powers, Jeffery W. Kelly, Neil J. Grimsey, Michel Michaelides, Joseph Carroll, R. Luke Wiseman, Jonathan H. Lin   +13 more
openaire   +3 more sources

Roles and Clinical Significances of ATF6, EMC6, and APAF1 in Prognosis of Pancreatic Cancer

Frontiers in Genetics, 2022
Background: Pancreatic cancer (PC) is prevalent among malignant tumors with poor prognosis and lacks efficient therapeutic strategies. Endoplasmic reticulum (ER) stress and apoptosis are associated with chronic inflammation and cancer progression ...
Wang Xiao, Rong-Chang Cao, Wan-Jun Yang, Jie-Hui Tan, Ruo-Qi Liu, He-Ping Kan, Lei Zhou, Na Zhang, Zhi-Ye Chen, Xue-Mei Chen, Jia Xu, Guo-Wei Zhang, Peng Shen   +12 more
doaj   +1 more source

Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]

, 2016
Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan, Diaz-Salazar, Carlos, Eltis, Lindsay D, Liu, Jie, Otani, Hiroshi, Seghezzi, Nicolas   +5 more
core   +2 more sources

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P., Liu, X., Martin, Nigel, Orengo, C.A., Swift, S., Tucker, A., Vinciotti, V.   +6 more
core   +2 more sources

691 ATF6 activation promotes ICB response in melanoma [PDF]

Regular and Young Investigator Award Abstracts
Jacob L Edmondson, Sanjay Adhikary, Daniel Fil, Megan R. Reed, Billie Heflin, Katherine Wallis, Sydnye L. Shuttleworth, Nathan L. Avaritt, lan J Tackett, Brian Koss   +9 more
openalex   +2 more sources

The Unfolded Protein Response Regulator, ATF6, Promotes Mesodermal Differentiation [PDF]

The FASEB Journal, 2018
ATF6 encodes a transcription factor that is activated during the Unfolded Protein Response to protect cells from ER stress. Loss of ATF6α and its paralog ATF6β, results in embryonic lethality, notochord dysgenesis, and in people, loss of ATF6α specifically, results in malformed neuroretina and congenital vision loss.
Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Lars Plate, Ying Jones, Peter X. Shaw, JoAnn Trejo, Stephen H. Tsang, Evan Powers, Jeffery W. Kelly, R. Luke Wiseman, Jonathan H. Lin   +12 more
openaire   +5 more sources

Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Frontiers in Neuroscience, 2018
Neuronal apoptosis is an important factor accounting for the poor outcomes of intracerebral hemorrhage (ICH). This study first showed that inhibition of activating transcription factor 6 (ATF6) could alleviate secondary brain injury through anti ...
Weilin Xu, Xiaoyang Lu, Jingwei Zheng, Tao Li, Liansheng Gao, Cameron Lenahan, Anwen Shao, Jianmin Zhang, Jianmin Zhang, Jianmin Zhang, Jun Yu   +10 more
doaj   +1 more source

A Systems Biology Approach towards Deciphering the Unfolded Protein Response in Huntington's Disease [PDF]

, 2012
Although the disease causing gene huntingtin has been known for some time, the exact cause of neuronal cell death during _Huntington's disease_ (HD) remains unknown.
Kameshwar R. Ayasolla, Matthias E. Futschik, Ravi K. R. Kalathur   +2 more
core   +2 more sources

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

Journal of Biological Chemistry, 2000
ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6 has been implicated in the endoplasmic reticulum (ER) stress response pathway since it can activate expression of GRP78 and other genes induced by the ER stress response.
Y, Wang, J, Shen, N, Arenzana, W, Tirasophon, R J, Kaufman, R, Prywes   +5 more
openaire   +2 more sources