Results 51 to 60 of about 29,072 (277)

Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes

Nature Communications, 2022
Axial length is the primary determinant of eye size, and it is elongated in myopia. However, the underlying mechanism of the onset and progression of axial elongation remain unclear.
S. Ikeda, T. Kurihara, Xiaoyan Jiang, Yukihiro Miwa, Deokho Lee, Naho Serizawa, Heonuk Jeong, Kiwako Mori, Yusaku Katada, Hiromitsu Kunimi, Nobuhiro Ozawa, Chiho Shoda, Mari Ibuki, K. Negishi, H. Torii, K. Tsubota   +15 more
semanticscholar   +1 more source

Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways

Cells, 2022
Cancer cell survival, function and fate strongly depend on endoplasmic reticulum (ER) proteostasis. Although previous studies have implicated the ER stress signaling network in all stages of cancer development, its role in cancer metastasis remains to be
Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Z. Fu, Youheng Jiang, Chang-Xue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, C. Costa, Xia Sheng, Yulong He, Ningning Li   +13 more
semanticscholar   +1 more source

Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That Is Shared with the Viral Transcription Factor, VP16 [PDF]

Journal of Biological Chemistry, 2002
ATF6 is a 670-amino acid endoplasmic reticulum (ER) transmembrane protein that is cleaved in response to ER stress. The resulting N-terminal fragment of approximately 400 amino acids translocates to the nucleus and activates selected ER stress-inducible genes, such as GRP-78 and sarco/endoplasmic reticulum ATPase, which are required for cell survival ...
Lisa E. Morrison, Holly Hoover, Donna J. Thuerauf, Christopher C. Glembotski   +3 more
openaire   +3 more sources

Molecular mechanisms involved in endoplasmic reticulum stress development: What do we know today [PDF]

Medicinski Podmladak
Endoplasmic reticulum (ER) is an intracellular organelle involved in protein synthesis and folding. When the balance between cell needs for proteins and ER capacity to fold proteins is disrupted, nonfunctional, unfolded, or misfolded proteins accumulate ...
Vidičević-Novaković Sašenka, Stanojević Željka   +1 more
doaj   +1 more source

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Cell & Bioscience, 2022
Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABA A ) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy.
Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, J. Lynch, R. Wiseman, J. Kelly, A. Keramidas, Ting-Wei Mu   +9 more
semanticscholar   +1 more source

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels [PDF]

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Ayoubi, T.A., Bruin, T.W., Feskens, E.J.M., Glembotski, C.C., Greevenbroek, M.M., Heldens, J., Hofker, M.H., Kallen, C.J., Kuusisto, J., Laakso, K., Meex, S.J., Pajukanta, P., Schalkwijk, C.G., Sinsheimer, J.S., Stehouwer, C.D., Taskinen, M.R., Thuerauf, D.J., Vlietinck, R., Weissglas-Volkov, D., Wouters, B.G.   +19 more
core   +1 more source

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. [PDF]

, 2018
BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation ...
Fu, Z, Hu, Q, Ke, X, Li, P, Liu, Y, Sun, J, Tan, Z, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +11 more
core   +1 more source

Macular maldevelopment inATF6-mediated retinal dysfunction [PDF]

Ophthalmic Genetics, 2019
Background: Achromatopsia has been previously associated with mutations in the ATF6 gene. Rod-monochromatism, foveal hypoplasia, and disruption of the subfoveal photoreceptor layer are described as phenotypical features. We report detailed structural and electrophysiological assessment of two patients from two families, one manifesting severe macular ...
Markus Ritter, Markus Ritter, Andrew R. Webster, Andrew R. Webster, Gavin Arno, Graham E. Holder, Graham E. Holder, Graham E. Holder, Rola Ba-Abbad, Rola Ba-Abbad   +9 more
openaire   +4 more sources

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources

Molecular mechanism of ATF6 regulating the reproduction related gene HSPA1L [PDF]

Jichu yixue yu linchuang
Objective To explore the effect of endoplasmic reticulum stress activating transcription factor 6 (ATF6) on the expression of reproduction related gene heat shock protein family A member 1 like (HSPA1L) and preliminarily clarify its regulatory molecular ...
WANG Yuanyuan, ZHU Xilin, WU Xiaopan, LIU Ying
doaj   +1 more source