Results 61 to 70 of about 29,072 (277)

Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). [PDF]

, 2014
Selenium (Se) is an essential micronutrient that can cause embryotoxicty at levels 7-30 times above essential concentrations. Exposure to hypersaline conditions and 50 μM selenomethionine (SeMet) decreased embryo hatch and depleted glutathione in ...
Kupsco, Allison, Schlenk, Daniel
core   +1 more source

ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer.

Molecular Cancer Research, 2022
High grade serous ovarian cancer (HGSOC) is the deadliest ovarian cancer histotype due in-part to the lack of therapeutic options for chemotherapy resistant disease. Poly(ADP)-ribose polymerase inhibitors (PARPi) represent a targeted treatment.
Alexandra McMellen, Tomomi M Yamamoto, L. Qamar, B. Sanders, Lily L Nguyen, Daniela Ortiz Chavez, Jaidev Bapat, Amber A Berning, M. Post, Joshua Johnson, K. Behbakht, Elmar Nurmemmedov, E. Chuong, Benjamin G. Bitler   +13 more
semanticscholar   +1 more source

Achromatopsia mutations target sequential steps of ATF6 activation [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance The unfolded protein response regulator activating transcription factor 6 ( ATF6 ) was recently identified as a novel genetic cause of the cone photoreceptor disease achromatopsia. ATF6 upregulates genes that help cells cope with endoplasmic reticulum stress.
Anna Skorczyk-Werner, Priscilla Chan, Elise Héon, Susanne Kohl, Stephen H. Tsang, Maciej R Krawczyński, Jonathan H. Lin, Bernd Wissinger, Ajoy Vincent, Randal J. Kaufman, Wei-Chieh Chiang   +10 more
openaire   +3 more sources

Characterization of key triacylglycerol biosynthesis processes in rhodococci. [PDF]

, 2016
Oleaginous microorganisms have considerable potential for biofuel and commodity chemical production. Under nitrogen-limitation, Rhodococcus jostii RHA1 grown on benzoate, an analog of lignin depolymerization products, accumulated triacylglycerols (TAGs ...
Amara, Sawsan, Diaz-Salazar, Carlos, Eltis, Lindsay D, Liu, Jie, Otani, Hiroshi, Seghezzi, Nicolas   +5 more
core   +2 more sources

Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy

Journal of Virology, 2022
PPRV infection induces cellular autophagy; however, the intracellular responses and signaling mechanisms that occur upon PPRV infection are obscure, and whether innate immune responses are linked with autophagy to regulate viral replication is largely ...
Rui Zhang, Hanrui Lin, Q. You, Zhixiong Zhang, L. Bai, Fei Chen, Xueliang Zhu, Zhidong Zhang, Yanmin Li   +8 more
semanticscholar   +1 more source

The Luminal Domain of ATF6 Senses Endoplasmic Reticulum (ER) Stress and Causes Translocation of ATF6 from the ER to the Golgi [PDF]

Journal of Biological Chemistry, 2002
ATF6 is an endoplasmic reticulum (ER) transmembrane transcription factor that is activated by the ER stress/unfolded protein response by cleavage of its N-terminal half from the membrane. We find that ER stress induces ATF6 to move from the ER to the Golgi, where it is cut in its luminal domain by site 1 protease.
Jingshi Shen, Ron Prywes, Xi Chen
openaire   +3 more sources

How are proteins reduced in the endoplasmic reticulum? [PDF]

, 2018
The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil, Ellgaard, Lars, Sevier, Carolyn S.   +2 more
core   +2 more sources

Uterine Endoplasmic Reticulum Stress and Its Unfolded Protein Response May Regulate Caspase 3 Activation in the Pregnant Mouse Uterus [PDF]

, 2013
We have previously proposed that uterine caspase-3 may modulate uterine contractility in a gestationally regulated fashion. The objective of this study was to determine the mechanism by which uterine caspase-3 is activated and consequently controlled in ...
Condon, Jennifer C., Jeyasuria, Pancharatnam, Kyathanahalli, Chandrashekara, Lydon, John P., Subedi, Kalpana, Suresh, Arvind   +5 more
core   +7 more sources

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

eLife, 2018
Pharmacologic arm-selective unfolded protein response (UPR) signaling pathway activation is emerging as a promising strategy to ameliorate imbalances in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases.
Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers, R Luke Wiseman, Jeffery W Kelly   +6 more
doaj   +1 more source

Flurochloridone Induced Cell Apoptosis via ER Stress and eIF2α-ATF4/ATF6-CHOP-Bim/Bax Signaling Pathways in Mouse TM4 Sertoli Cells

International Journal of Environmental Research and Public Health, 2022
Flurochloridone (FLC), as a novel herbicide, has been widely used in many countries since 1980s. Current studies have shown that FLC has toxic effects on male reproduction and its target organ is testis, while the underlying mechanism is still unknown ...
Fen Zhang, Zhijing Ni, Shuqing Zhao, Yanna Wang, X. Chang, Zhijun Zhou   +5 more
semanticscholar   +1 more source