Results 111 to 120 of about 1,926,024 (211)
Dynamics of α-helical subdomain rotation in the intact maltose ATP-binding cassette transporter
, 2010 ATP-binding cassette (ABC) transporters are powered by a nucleotide-binding domain dimer that opens and closes during cycles of ATP hydrolysis. These domains consist of a RecA-like subdomain and an α-helical subdomain that is specific to the
Frances Joan D. Alvarez +6 more
core +1 more source
Cardiovascular TherapeuticsCardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, and hyperlipidemia is one major inducing factor of CVD. It is worthy to note that fucoidans are reported to have hypolipidemic activity with species specificity ...
Yan Zhang +5 more
doaj +1 more source
Structural Features of the ATP-Binding Cassette (ABC) Transporter ABCA3
, 2015 In this review we reported and discussed the structural features of the ATP-Binding Cassette (ABC) transporter ABCA3 and how the use of bioinformatics tools could help researchers to obtain a reliable structural model of this important transporter.
Alessandro Paolini +3 more
core +1 more source
ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia [PDF]
The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance.
Harris, Neil +11 more
core +1 more source
Loss of IGFBP-6 promotes monocyte-driven atherogenesis in periodontal disease
Scientific ReportsPeriodontitis has been associated with an increased risk of atherosclerosis, potentially through altered systemic monocyte and macrophage function.
Dáire Shanahan +8 more
doaj +1 more source
, 2008 The macrophage plays a key role in atherogenesis, including in the uptake of cholesterol which lead to the formation of fatty streaks. So its ability to eliminate cholesterol in excess is critical for the development of pathology.
Larrède, Sandra
core +3 more sources
Characterisation of the vibrio cholerae antibiotic resistance var operon [PDF]
, 2007 The discovery and use of antibiotics in the chemotherapy of bacterial infections has revolutionised medicine as it is today. Unfortunately, the progressive use of antibiotics has promoted the evolution of bacterial defences against these mediators and ...
Massam-Wu, Teresa
core
Cyanidin-3-glucoside: targeting atherosclerosis through gut microbiota and anti-inflammation
Frontiers in NutritionWith the shifting global disease spectrum, atherosclerosis (AS) has emerged as a leading contributor to mortality worldwide, with associated cardiovascular diseases (CVDs) representing the predominant cause of death. AS, a chronic inflammatory pathology,
Zihan Tang
doaj +1 more source
JCI InsightSphingosine 1-phosphate (S1P) is a lysosphingolipid with antiatherogenic properties, but mechanisms underlying its effects remain unclear. We here investigated atherosclerosis development in cholesterol-rich diet–fed LDL receptor–deficient mice with high
Francesco Potì +19 more
doaj +1 more source
Cholesterol Accumulation Enhances Cigarette Smoke-Induced Airway Epithelial Inflammation
International Journal of COPDDu Jing,1,2 Jin-Kang Yu,1 Hai-Pin Chen,1 Ling-Ling Dong,1 Wen Li,1 Zhou-Yang Li,1 Jie-Sen Zhou1 1Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of ...
Jing D +6 more
doaj