Results 101 to 110 of about 1,926,024 (211)

Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate

Toxins, 2015
One of the possible causes of enhanced atherosclerosis in patients with chronic kidney disease (CKD) is the accumulation of uremic toxins. Since macrophage foam cell formation is a hallmark of atherosclerosis, we examined the direct effect of indoxyl ...
Koji Matsuo, Suguru Yamamoto, Takuya Wakamatsu, Yoshimitsu Takahashi, Kazuko Kawamura, Yoshikatsu Kaneko, Shin Goto, Junichiro J. Kazama, Ichiei Narita   +8 more
doaj   +1 more source

Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus

, 2008
Leukocyte ATP-Binding Cassette Transporter G1 Gene Expression is Reduced in Type 2 Diabetes Mellitus Reverse cholesterol transport Reverse cholesterol transport is a pathway which transports cholesterol from extrahepatic cells and tissues to the liver ...
Wong, Y, Tan, KCB, Zhou, H, Shiu, SWM
core  

SR-BI associates with ABCG1 and inhibits ABCG1-mediated cholesterol efflux from cells to high-density lipoprotein 3

Lipids in Health and Disease, 2012
Background The single and combined effects of scavenger receptor-BI (SR-BI), ATP-binding cassette transporter (ABC) A1 and G1 on cholesterol efflux from Chinese Hamster Ovary (CHO) cells were investigated. Results When apolipoproteinA-I (apoA-I) was used
Song Guohua, Zong Chuanlong, Liu Qian, Si Yanhong, Liu Jie, Li Wei, Zhu Ping, Qin Shucun   +7 more
doaj   +1 more source

The yeast plasma membrane ATP binding cassette (ABC) transporter aus1

, 2011
The ATP binding cassette (ABC) transporter Aus1 is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and is required for sterol uptake. These observations suggest that Aus1 promotes the translocation
Herrmann, A., Dittmar, G., Marek, M., Gunnar Dittmar, Marek, Magdalena, Günther-Pomorski, Thomas, Gabriele Schreiber, Schreiber, Gabriele, Magdalena Marek, Daleke, D.L., Sigrid Milles, Schreiber, G., Thomas Günther Pomorski, Milles, S., Mueller, P., Müller, Peter, Herrmann, Andreas, Milles, Sigrid, Andreas Herrmann, Daleke, David L., Peter Müller, David L. Daleke, Pomorski, T.G., Dittmar, Gunnar   +23 more
core   +1 more source

ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype

Cellular & Molecular Biology Letters, 2017
Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists.
Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino, Faustino Bisaccia   +6 more
doaj   +1 more source

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL

Journal of Lipid Research, 2008
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet, Tamara A. Pagler, Nan Wang, Takafumi Senokuchi, May Brundert, Hongna Li, Franz Rinninger, Alan R. Tall   +7 more
doaj   +1 more source

Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.: BMP and LXRs/ABCs pathway in macrophages

, 2013
International audienceOBJECTIVE: Endosomal signature phospholipid bis(monoacylglycero)phosphate (BMP) has been involved in the regulation of cellular cholesterol homeostasis.
Arnal-Levron, Maud, Kobayashi, Toshihide, Sakaï, Shota, Moulin, Philippe, Luquain-Costaz, Céline, Lefai, Etienne, Makino, Asami, Guichardant, Michel, Lagarde, Michel, Markina, Daria, Yamashita, Shizuya, Euthine, Vanessa, Delton-Vandenbroucke, Isabelle   +12 more
core   +1 more source

Investigating the mechanism of the E.coli ATP-binding cassette transporter MetNI [PDF]

, 2020
Intracellular chemical homeostasis is vital for cell survival. A key component for the maintenance of this homeostasis is ABC (ATP-binding cassette) transporters.
Foronda, Matthew
core  

Up-regulation of ABCG1 is associated with methotrexate resistance in acute lymphoblastic leukemia cells

Frontiers in Pharmacology
Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy in children, and methotrexate (MTX) is a widely employed curative treatment. Despite its common use, clinical resistance to MTX is frequently encountered.
Yao Chen, Houshun Fang, Huiying Sun, Xiaoyu Wu, Yan Xu, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Bin-Bing S. Zhou, Hui Li, Hui Li   +9 more
doaj   +1 more source

Lung Cancer Inhibition by Betulinic Acid Nanoparticles via Adenosine 5'-Triphosphate (ATP)-Binding Cassette Transporter G1 Gene Downregulation. [PDF]

Med Sci Monit, 2020
Zhao H, Mu X, Zhang X, You Q.
europepmc   +1 more source