Results 161 to 170 of about 1,926,024 (211)

ATP-binding cassette transporter G1 and lipid homeostasis

Current Opinion in Lipidology, 2006
This review briefly discusses the ATP-binding cassette transporter G (ABCG) family members and emphasizes recent studies that identify ABCG1 as a key regulator of cellular lipid homeostasis.The in-vivo importance of ABCG1 has recently been demonstrated with both loss-of-function and gain-of-function studies in mice.
Angel, Baldán, Paul, Tarr, Richard, Lee, Peter A, Edwards   +3 more
openaire   +2 more sources

ATP-binding cassette transporter G1 (ABCG1) polymorphisms in pregnant women with gestational diabetes mellitus

European Journal of Obstetrics & Gynecology and Reproductive Biology, 2023
Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnancy, and it often leads to adverse pregnancy outcomes and seriously harms the health of mothers and infants. ATP-binding cassette transporter G1 (ABCG1) plays critical roles in high-density lipoprotein (HDL) metabolism and reverse cholesterol transport.
Sixu, Liu, Linbo, Guan, Xinghui, Liu, Ping, Fan, Mi, Zhou, Yujie, Wu, Rui, Liu, Fangmei, Tang, Yufeng, Wang, Dehua, Li, Huai, Bai   +10 more
openaire   +2 more sources

Characterization of palmitoylation of ATP binding cassette transporter G1: Effect on protein trafficking and function

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013
ATP-binding cassette transporter G1 (ABCG1) mediates cholesterol efflux onto lipidated apolipoprotein A-I and HDL and plays a role in various important physiological functions. However, the mechanism by which ABCG1 mediates cholesterol translocation is unclear. Protein palmitoylation regulates many functions of proteins such as ABCA1.
Hong-mei, Gu, Ge, Li, Xia, Gao, Luc G, Berthiaume, Da-wei, Zhang   +4 more
openaire   +2 more sources

Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
openaire   +2 more sources

Associations of ATP-Binding Cassette Transporter A1 and G1 With Insulin Secretion in Human Insulinomas

Pancreas, 2012
Adenosine triphosphate-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) are 2 important cholesterol transporters in human pancreatic β-cells. The aim of this study was to investigate their alteration in insulinomas and their potential associations with abnormal insulin secretion in these patients.Six patients with insulinoma and 6 healthy ...
Huali, Zhou, Chengjiang, Li, Jun, Li, Hongtian, Yao, Rong, Su, Wenpeng, Li, Mingzhi, Xu   +6 more
openaire   +2 more sources

ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose

Diabetes Research and Clinical Practice, 2013
ATP binding cassette transporter G1 (ABCG1), a regulator of cholesterol efflux to HDL, has been shown to decrease in macrophages and smooth muscle cells under high glucose conditions. Endothelial cells have a high capacity to efflux sterols and express ABCG1.
Jiahong, Xue, Congxia, Wang, Canzhan, Zhu, Yongqin, Li   +3 more
openaire   +2 more sources

Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
ABC transporter G1 (ABCG1) plays a pivotal role in HDL-mediated cholesterol efflux and atherogenesis. We investigated whether, and how, retinoic acid receptors (RARs) regulate ABCG1 expression in macrophages. All-trans retinoic acid (ATRA), an RAR ligand, increased ABCG1 protein levels and apoA-I/HDL-mediated cholesterol efflux from the macrophages ...
Makoto, Ayaori, Emi, Yakushiji, Masatsune, Ogura, Kazuhiro, Nakaya, Tetsuya, Hisada, Harumi, Uto-Kondo, Shunichi, Takiguchi, Yoshio, Terao, Makoto, Sasaki, Tomohiro, Komatsu, Maki, Iizuka, Makiko, Yogo, Yoshinari, Uehara, Hiroyuki, Kagechika, Tsuyoshi, Nakanishi, Katsunori, Ikewaki   +15 more
openaire   +2 more sources

The role of ATP‐binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms

Basic & Clinical Pharmacology & Toxicology
AbstractThe maintenance of cholesterol homeostasis is essential for central nervous system function. Consequently, factors that affect cholesterol homeostasis are linked to neurological disorders and pathologies. Among them, ATP‐binding cassette transporter G1 (ABCG1) plays a significant role in atherosclerosis. However, its role in Alzheimer's disease
Mohsen Karbasi Yazdi, Mohaddeseh Sadat Alavi, Ali Roohbakhsh   +2 more
openaire   +2 more sources

[The research progress of ATP binding cassette transporter G1].

Sheng li ke xue jin zhan [Progress in physiology], 2012
ATP binding cassette transporter G1 (ABCG1) is a membrane half-transporter which is the member of ATP-binding cassette (ABC) transporter super-family, it has an important role of regulating the cholesterol and phospholipids effluence. ABCG1 and ABCA1 synergize to mediate cholesterol effluence to HDL (high density lipoprotein).
Xie-Hong, Liu, Chao-Ke, Tang
openaire   +1 more source