Results 171 to 180 of about 1,926,024 (211)

Identification of an amino acid residue in ATP-binding cassette transport G1 critical for mediating cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
The ATP-binding cassette transporter G1 (ABCG1) mediates free cholesterol efflux onto lipidated apolipoprotein A-I (apoA-I) and plays an important role in macrophage reverse cholesterol transport thereby reducing atherosclerosis. However, how ABCG1 mediates the efflux of cholesterol onto lipidated apoA-I is unclear.
Xia, Gao, Hongmei, Gu, Ge, Li, Kerry-Anne, Rye, Da-Wei, Zhang   +4 more
openaire   +2 more sources

Association of ATP-Binding Cassette Transporter G1 Polymorphisms with Risk of Ischemic Stroke in the Chinese Han Population

Journal of Stroke and Cerebrovascular Diseases, 2015
The adenosine triphosphate (ATP)-binding cassette transporter G1 (ABCG1), a member of the superfamily of ATP-binding cassette transporters, is involved in the transport of cholesterol and phospholipids in macrophages. As such, ABCG1 plays a crucial role in the development of atherosclerosis in humans.
Qu, Li, Xu, Liu, Ruixia, Zhu, Zhiyi, He
openaire   +2 more sources

Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017
Impaired cholesterol/lipoprotein metabolism is linked to neurodegenerative diseases such as Alzheimer's disease (AD). Cerebral cholesterol homeostasis is maintained by the highly efficient blood-brain barrier (BBB) and flux of the oxysterols 24(S)-hydroxycholesterol and 27-hydroxycholesterol, potent liver-X-receptor (LXR) activators.
Alexandra Carmen, Kober, Anil Paul Chirackal, Manavalan, Carmen, Tam-Amersdorfer, Andreas, Holmér, Ahmed, Saeed, Elham, Fanaee-Danesh, Martina, Zandl, Nicole Maria, Albrecher, Ingemar, Björkhem, Gerhard M, Kostner, Björn, Dahlbäck, Ute, Panzenboeck   +11 more
openaire   +2 more sources

Ethanolic Extract of Propolis Promotes Reverse Cholesterol Transport and the Expression of ATP‐Binding Cassette Transporter A1 and G1 in Mice

Lipids, 2011
AbstractThe ethanolic extract of propolis (EEP) is beneficial in increasing high density lipoprotein (HDL) cholesterol (HDL‐C) and diminishing risks of atherosclerosis. In this study, we examined the effects of EEP on reverse cholesterol transport in mice.
Yang, Yu, Yanhong, Si, Guohua, Song, Tian, Luo, Jiafu, Wang, Shucun, Qin   +5 more
openaire   +2 more sources

Endothelin‐1 exacerbates lipid accumulation by increasing the protein degradation of the ATP‐binding cassette transporter G1 in macrophages

Journal of Cellular Physiology, 2011
AbstractEndothelin‐1 (ET‐1), a potent proatherogenic vasoconstrictive peptide, is known to promote macrophage foam cell formation via mechanisms that are not fully understood. Excessive lipid accumulation in macrophages is a major hallmark during the early stages of atherosclerotic lesions.
Chun-Yueh, Lin, Tzong-Shyuan, Lee, Chin-Chang, Chen, Cheng-An, Chang, Yan-Jie, Lin, Yung-Pei, Hsu, Low-Tone, Ho   +6 more
openaire   +2 more sources

Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages

The Journal of Nutritional Biochemistry, 2012
Reverse cholesterol transport (RCT), a process to deliver excess cholesterol from the periphery to the liver for excretion from body, is a major atheroprotective property of high-density lipoproteins. As major transporters for cholesterol efflux in macrophages, ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) are critical for RCT.
Chai Siah, Ku, Youngki, Park, Sara L, Coleman, Jiyoung, Lee   +3 more
openaire   +2 more sources

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2.
Hong-Mei, Gu, Fa-Qi, Wang, Da-Wei, Zhang
openaire   +2 more sources

3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency

Atherosclerosis, 2014
Oxysterols are oxidized derivatives of sterols that have cytotoxic effects and are potent regulators of diverse cellular functions. Efficient oxysterol removal by the sub-family G member 1 of the ATP-binding cassette transporters (ABCG1) is essential for cell survival and control of cellular processes.
Thomas, Engel, Manfred, Fobker, Jana, Buchmann, Frank, Kannenberg, Stephan, Rust, Jerzy-Roch, Nofer, Annette, Schürmann, Udo, Seedorf   +7 more
openaire   +2 more sources

ATP‐binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

The FASEB Journal, 2007
Transporters in the ABCG family appear to be involved in the cellular excretion of cholesterol and other sterols in a cell‐ and tissue‐specific fashion. Overexpression of ATP‐binding cassette transporters G1 (Abcgl) and G4 (Abcg4) can promote cellular cholesterol efflux to high‐density lipoprotein (HDL), but the
Wang, Nan, Yvan-Charvet, Laurent, Lütjohann, Dieter, Mulder, Monique, Vanmierlo, Tim, Kim, Tae-Wan, Tall, Alan R   +6 more
openaire   +3 more sources

ATP-Binding Cassette Transporters A1 and G1, HDL Metabolism, Cholesterol Efflux, and Inflammation: Important Targets for the Treatment of Atherosclerosis

Current Drug Targets, 2011
Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol deposition in arteries. Plasma high density lipoprotein (HDL) levels bear a strong independent inverse relationship with atherosclerotic cardiovascular disease. One central antiatherogenic role of HDL is believed to be its ability to remove excessive peripheral ...
Dan, Ye, Bart, Lammers, Ying, Zhao, Illiana, Meurs, T J, Van Berkel, Miranda, Van Eck   +5 more
openaire   +2 more sources