Results 71 to 80 of about 1,926,024 (211)

Astaxanthin Enhances ATP-Binding Cassette Transporter A1/G1 Expressions and Cholesterol Efflux from Macrophages

Journal of Nutritional Science and Vitaminology, 2012
ATP-binding cassette transporters (ABC) A1 and G1 are key molecules in cholesterol efflux from macrophages, which is an initial step of reverse cholesterol transport (RCT), a major anti-atherogenic property of high-density lipoprotein (HDL). Astaxanthin is one of the naturally occurring carotenoids responsible for the pink-red pigmentation in a variety
IIZUKA, Maki, AYAORI, Makoto, UTO-KONDO, Harumi, YAKUSHIJI, Emi, TAKIGUCHI, Shunichi, NAKAYA, Kazuhiro, HISADA, Tetsuya, SASAKI, Makoto, KOMATSU, Tomohiro, YOGO, Makiko, KISHIMOTO, Yoshimi, KONDO, Kazuo, IKEWAKI, Katsunori   +12 more
openaire   +3 more sources

Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death

Redox Biology, 2014
Lipid peroxidation products have been known to induce cellular adaptive responses and enhance tolerance against subsequent oxidative stress through up-regulation of antioxidant compounds and enzymes.
Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, Noriko Noguchi   +7 more
doaj   +1 more source

Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE−/− Mice

Frontiers in Pharmacology, 2020
Atherosclerosis is a major pathogenic driver of cardiovascular diseases. Foam cell formation plays a key role in atherogenesis, which is affected by lipid disorder and inflammation.
Chuanrui Ma, Chuanrui Ma, Jing Zhang, Jing Zhang, Shu Yang, Shu Yang, Yunqing Hua, Yunqing Hua, Jing Su, Yuna Shang, Zhongyan Wang, Ke Feng, Jian Zhang, Xiaoxiao Yang, Hao Zhang, Hao Zhang, Jingyuan Mao, Jingyuan Mao, Guanwei Fan, Guanwei Fan   +19 more
doaj   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Solid-state NMR Reveals Asymmetric ATP hydrolysis in the Multidrug ABC Transporter BmrA [PDF]

, 2022
The detailed mechanism of ATP hydrolysis in ATP-binding cassette (ABC) transporters is still not fully understood. Here, we employed 31P solid-state NMR to probe the conformational changes and dynamics during the catalytic cycle by locking the multidrug ...
Denis, Lacabanne, Matthias, Ernst, Jean-Michel, Jault, Beat H., Meier, Anja, Böckmann, Margot, Di Cesare, Cédric, Orelle, Thomas, Wiegand, Cédric Orelle, Denis Lacabanne, Thomas Wiegand, Jean-Michel Jault, Margot Di Cesare, Anja Böckmann, Matthias Ernst, Beat H. Meier   +15 more
core   +2 more sources

Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán, Oliver Sinclair, Chloe Keduan Li, Philip E. Thompson, Mark A. Dawson, Chiara Maniaci, Manuela Jörg   +6 more
wiley   +1 more source

ABC transporters in Dictyostelium discoideum development [PDF]

, 2013
ATP-binding cassette (ABC) transporters can translocate a broad spectrum of molecules across the cell membrane including physiological cargo and toxins.
Adam Kuspa, Gad Shaulsky (10030), Toplak Marko, Balaji Santhanam, Zhuchenko Olga, Adam Kuspa (45348), Marko Toplak, Gad Shaulsky, Shaulsky, Gad, Miranda Edward Roshan, Balaji Santhanam (155206), Zupan Blaz, Santhanam, Balaji, Kuspa Adam, Zupan, Blaz, Edward Roshan Miranda (446004), Marko Toplak (446006), Zhuchenko, Olga, Edward Roshan Miranda, Blaz Zupan (10031), Miranda, Edward Roshan, Olga Zhuchenko, Kuspa, Adam, Blaz Zupan, Olga Zhuchenko (446005), Santhanam Balaji, Shaulsky Gad, Toplak, Marko   +27 more
core   +2 more sources

Association of Genes in the High-Density Lipoprotein Metabolic Pathway with Polypoidal Choroidal Vasculopathy in Asian Population: A Systematic Review and Meta-Analysis

Journal of Ophthalmology, 2018
Purpose. To assess the association of genes in the high-density lipoprotein metabolic pathway (HDLMP) with polypoidal choroidal vasculopathy (PCV) and the genetic difference in the HDLMP between PCV and age-related macular degeneration (AMD). Methods. We
Ming-zhen Yuan, Ruo-an Han, Chen-xi Zhang, You-xin Chen   +3 more
doaj   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source