Results 161 to 170 of about 45,380 (194)

Dual regulation of the ATP-sensitive potassium channel by caffeine

American Journal of Physiology-Cell Physiology, 2007
ATP-sensitive potassium (KATP) channels couple cellular metabolic status to changes in membrane electrical properties. Caffeine (1,2,7-trimethylxanthine) has been shown to inhibit several ion channels; however, how caffeine regulates KATPchannels was not well understood.
Xia, Mao, Yongping, Chai, Yu-Fung, Lin
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ATP-Sensitive Potassium Channel Modulators and Cardiac Arrhythmias: An Update [PDF]

Current Pharmaceutical Design, 2014
Ischemia and heart failure-related cardiac arrhythmias, both atrial (e.g., atrial fibrillation) and ventricular (e.g., malignant tachyarrhythmias) represent a leading cause of morbidity and mortality worldwide. Despite the progress made in the last decade in understanding their pathophysiological mechanisms there is still an unmet need for safer and ...
Muntean, Danina, Kiss, Loránd, Jost, Norbert, Baczkó, István   +3 more
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Trafficking of ATP-sensitive potassium channels in health and disease

Biochemical Society Transactions, 2007
KATP channels (ATP-sensitive potassium channels), comprising four subunits each of Kir6.2 (inwardly rectifying potassium channel 6.2) and the SUR1 (sulfonylurea receptor 1), play a central role in glucose-stimulated insulin secretion by the pancreatic β-cell.
Sivaprasadarao, A., Taneja, T. K., Mankouri, J., Smith, A. J.   +3 more
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THE SULPHONYLUREA RECEPTOR MAY BE AN ATP-SENSITIVE POTASSIUM CHANNEL

The Lancet, 1985
The stimulation of insulin secretion from the beta cells of the islets of Langerhans appears to be mediated by a decrease in the cell-membrane potassium-ion permeability. Tolbutamide reduced K+ movement through an ATP-sensitive K+ channel in patches of plasma membrane from an insulin-producing cell line when applied to the external surface of the ...
Sturgess, Nicholas C., Cook, Daniel L., Ashford, Michael L. J., Hales, C. Nicholas   +3 more
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ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

Annual Review of Physiology, 1999
▪ Abstract  ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular ...
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ATP-sensitive potassium channels: metabolic sensing and cardioprotection

Journal of Applied Physiology, 2007
The cardiovascular system operates under a wide scale of demands, ranging from conditions of rest to extreme stress. How the heart muscle matches rates of ATP production with utilization is an area of active investigation. ATP-sensitive potassium (KATP) channels serve a critical role in the orchestration of myocardial energetic well-being.
L V, Zingman, A E, Alekseev, D M, Hodgson-Zingman, A, Terzic   +3 more
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Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine 

Anesthesiology, 1997
Background The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel underlies the increase in potassium permeability during hypoxia and ischemia. The increased outward potassium current during ischemia may be an endogenous cardioprotective mechanism.
S H, Ko, S K, Lee, Y J, Han, H, Choe, Y G, Kwak, S W, Chae, K P, Cho, H S, Song   +7 more
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ATP-sensitive potassium channels in cultured arterial segments

American Journal of Physiology-Heart and Circulatory Physiology, 1996
Organ cultures of arteries have been used to study growth responses, proliferation, and contractility. However, the function of specific-ion channels in cultured arteries has not been investigated. ATP-sensitive K+ (KATP) channels play an important role in the control of arterial tone.
Kleppisch, Thomas, Winter, Barbara, Nelson, Mark T.; id_orcid 0000-0002-6608-8784   +2 more
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The Role of ATP Sensitive Potassium Channels in Myocardial Protection

Journal of Cardiac Surgery, 1995
Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A1-receptor agonists.
B A, Cason, H J, Gordon, E G, Avery, R F, Hickey   +3 more
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Modulation of ischemia by regulation of the ATP-sensitive potassium channel

Cardiovascular Drugs and Therapy, 1993
During acute myocardial ischemia, passage of potassium ions across the sarcolemma to the extracellular space is a well-established phenomenon. A recent hypothesis is that the ATP-dependent potassium channel plays a role in contributing to the potassium loss.
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