Results 191 to 200 of about 12,429 (225)

ATP Binding Cassette A1 Transporter Function and Tangier Disease

2010
The ATP binding cassette A1 (ABCA1) transporter facilitates the efflux of free cholesterol and phospholipid onto high density lipoprotein (HDL) particles, mainly very small discoidal precursor HDL particles, known as prebeta 1 HDL. Once these particles pick up these lipids, they are converted to small discoidal alpha 4 migrating HDL and with ...
Ernst J. Schaefer, H. Bryan Brewer
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Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism

DNA and Cell Biology, 2013
Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function.The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional ...
Yun-cheng, Lv, Kai, Yin, Yu-chang, Fu, Da-wei, Zhang, Wu-jun, Chen, Chao-ke, Tang   +5 more
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ATP binding cassette transporter A1 - key roles in cellular lipid transport and atherosclerosis

Molecular and Cellular Biochemistry, 2002
ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl esters in tissues, and increased risk of cardiovascular disease. Extensive studies for the past 2 years have recognized the critical role of ABCA1 in cholesterol and phospholipid ...
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Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis

Current Opinion in Lipidology, 2005
The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development ...
Miranda, Van Eck, Marieke, Pennings, Menno, Hoekstra, Ruud, Out, Theo Jc, Van Berkel   +4 more
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The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a β2-syntrophin/utrophin complex

Biochemical and Biophysical Research Communications, 2002
Recent work identified ABCA1 as the major regulator of plasma HDL-cholesterol responsible for the removal of excess choline-phospholipids and cholesterol from peripheral cells and tissues. ABCA1 function may depend on the association with heteromeric proteins and to identify these candidates a human liver yeast two-hybrid library was screened with the ...
Christa, Buechler, Alfred, Boettcher, Salim Maa, Bared, Mario C O, Probst, Gerd, Schmitz   +4 more
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[Screening and identification of the upregulators of ATP-binding cassette transporter A1].

Yao xue xue bao = Acta pharmaceutica Sinica, 2013
ATP-binding cassette transporter A1 (ABCA1) promotes cholesterol and phospholipid efflux from cells to lipid-poor apolipoprotein A-I (apoA-I), and plays a key role in the initial steps of the whole process of reverse cholesterol transport (RCT). Upregulation of ABCA1 is beneficial for atherosclerosis (AS) prevention and/or therapy, which indicated that
Yan-Ni, Xu, Jie, Gao, Yang, Xu, Ji-Kai, Liu, Fang-Fang, Lai, Ye-Xiang, Wu, Bin, Hong, Shu-Yi, Si   +7 more
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ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism

Gastroenterology, 2001
Members of the family of ABC transporters are involved in different processes of sterol metabolism, and ABCA1 was recently identified as a key regulator of high-density lipoprotein (HDL) metabolism. Our aim was to further analyze the role of ABCA1 in cholesterol metabolism.ABCA1-deficient mice (ABCA1-/-) and wild-type mice were compared for different ...
W, Drobnik, B, Lindenthal, B, Lieser, M, Ritter, T, Christiansen Weber, G, Liebisch, U, Giesa, M, Igel, H, Borsukova, C, Büchler, W P, Fung-Leung, K, Von Bergmann, G, Schmitz   +12 more
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Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
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Genetic variation of the ATP-binding cassette transporter A1 and susceptibility to coronary heart disease

Molecular Genetics and Metabolism, 2011
ATP-binding cassette transporter A1 (ABCA1) is a member of a superfamily of membrane proteins that has attracted considerable attention as a candidate gene for coronary heart disease (CHD) based on its enzyme function as a key factor in regulating plasma HDL-C and apo A-I metabolism.
Zhihui, Jiang, Rujuan, Zhou, Caixia, Xu, Guangzhi, Feng, Yafeng, Zhou   +4 more
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Associations of ATP-Binding Cassette Transporter A1 and G1 With Insulin Secretion in Human Insulinomas

Pancreas, 2012
Adenosine triphosphate-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) are 2 important cholesterol transporters in human pancreatic β-cells. The aim of this study was to investigate their alteration in insulinomas and their potential associations with abnormal insulin secretion in these patients.Six patients with insulinoma and 6 healthy ...
Huali, Zhou, Chengjiang, Li, Jun, Li, Hongtian, Yao, Rong, Su, Wenpeng, Li, Mingzhi, Xu   +6 more
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