Results 11 to 20 of about 321,932 (261)
cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions. [PDF]
PLoS ONE, 2012 We have shown that cystic fibrosis transmembrane conductance regulator (CFTR) is involved in ATP release from skeletal muscle at low pH. These experiments investigate the signal transduction mechanism linking pH depression to CFTR activation and ATP ...
Jie Tu +3 more
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Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]
PLoS ONE, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr +5 more
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Kinetics of urothelial ATP release [PDF]
American Journal of Physiology-Renal Physiology, 2006 Recent reports have proposed that the urothelium can sense mechanical stretch and communicate this information to sensory afferent neurons by the release of ATP into the vicinity of P2X-containing neurons. This report investigates the bidirectional release of ATP by in vitro rabbit urothelium.
Simon A, Lewis, Jamie R, Lewis
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ATP release from vascular endothelia occurs across Cx43 hemichannels and is attenuated during hypoxia. [PDF]
PLoS ONE, 2008 Extracellular ATP is an important signaling molecule for vascular adaptation to limited oxygen availability (hypoxia). Here, we pursued the contribution of vascular endothelia to extracellular ATP release under hypoxic conditions.We gained first insight ...
Marion Faigle +4 more
doaj +1 more source
Metabolites, 2022 Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of ...
Alejandro Gutierrez Cruz +4 more
doaj +1 more source
ATP release via anion channels [PDF]
Purinergic Signalling, 2005 ATP serves not only as an energy source for all cell types but as an 'extracellular messenger' for autocrine and paracrine signalling. It is released from the cell via several different purinergic signal efflux pathways. ATP and its Mg(2+) and/or H(+) salts exist in anionic forms at physiological pH and may exit cells via some anion channel if the pore
Sabirov, Ravshan Z., Okada, Yasunobu
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Lytic Release of Cellular ATP: Physiological Relevance and Therapeutic Applications
Life, 2021 The lytic release of ATP due to cell and tissue injury constitutes an important source of extracellular nucleotides and may have physiological and pathophysiological roles by triggering purinergic signalling pathways.
Ryszard Grygorczyk +7 more
doaj +1 more source
Physiological Reports, 2021 The release of ATP from the epithelium of the urinary bladder (urothelium) in response to mechanical/chemical stimuli contributes to the visceral sensation in the micturition reflex.
Eriko Okuyama +5 more
doaj +1 more source
ATP release from non-excitable cells [PDF]
Purinergic Signalling, 2009 All cells release nucleotides and are in one way or another involved in local autocrine and paracrine regulation of organ function via stimulation of purinergic receptors. Significant technical advances have been made in recent years to quantify more precisely resting and stimulated adenosine triphosphate (ATP) concentrations in close proximity to the ...
Helle A, Praetorius, Jens, Leipziger
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Taking a close look at a large-pore channel
eLife, 2020 The structure of pannexin 1, a channel protein with a large pore, has been determined for the first time.
Pablo S Gaete, Jorge E Contreras
doaj +1 more source