The persistent homology of mitochondrial ATP synthases [PDF]
iScience, 2023 Summary: Relatively little is known about ATP synthase structure in protists, and the investigated ones exhibit divergent structures distinct from yeast or animals.
Savar D. Sinha, Jeremy G. Wideman
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ATP Synthase Abundance in Neuronal Extracellular Vesicles Reflects Changes in the Mitochondria of Parent Neurons [PDF]
Journal of Extracellular VesiclesMitochondrial proteins are found in extracellular vesicles (EVs) such as neuron‐derived EVs (NEVs). Yet whether and how NEV‐borne mitochondrial proteins relate to the state of mitochondria in the parent neurons is unclear.
Pamela J. Yao +3 more
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Subtomogram averages of mitochondrial ATP synthase dimers from plants show a conserved extra density at the peripheral stalk [PDF]
IUCrJWe analyzed ATP synthase dimers in mitochondria purified from four plant species by subtomogram averaging, using Saccharomyces cerevisiae as a control.
Thorsten B. Blum +2 more
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ATP Synthase Members of Chloroplasts and Mitochondria in Rubber Trees (Hevea brasiliensis) Response to Plant Hormones [PDF]
PlantsATP synthase is a key enzyme in photophosphorylation in photosynthesis and oxidative phosphorylation in respiration, which can catalyze the synthesis of ATP and supply energy to organisms. ATP synthase has been well studied in many animal species but has
Bingbing Guo +5 more
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An overview of ATP synthase, inhibitors, and their toxicity [PDF]
Heliyon, 2023 Mitochondrial complex V (ATP synthase) is a remarkable molecular motor crucial in generating ATP and sustaining mitochondrial function. Its importance in cellular metabolism cannot be overstated, as malfunction of ATP synthase has been linked to various ...
Arwa R. Althaher, Mohammad Alwahsh
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Design, Synthesis, and Biological Evaluation of Mono- and Diamino-Substituted Squaramide Derivatives as Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthase. [PDF]
J Med ChemPalme PR +13 more
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Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis
Journal of Global Antimicrobial Resistance, 2022 : The ATP synthase is a multicomponent enzyme that is largely conserved across the kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by using the electrochemical proton gradient generated via the electron transport ...
Martin Vestergaard +2 more
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Autoantibodies to endothelial cell surface ATP synthase, the endogenous receptor for hsp60, might play a pathogenic role in vasculatides. [PDF]
PLoS ONE, 2011 BACKGROUND: Heat shock protein (hsp) 60 that provides "danger signal" binds to the surface of resting endothelial cells (EC) but its receptor has not yet been characterized. In mitochondria, hsp60 specifically associates with adenosine triphosphate (ATP)
Jean-Eric Alard +6 more
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Antibiotics, 2021 The ATP synthase has been validated as a druggable target with the approval of the ATP synthase inhibitor, bedaquiline, for treatment of drug-resistant Mycobacterium tuberculosis, a bacterial species in which the ATP synthase is essential for viability ...
Martin Vestergaard +2 more
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Communications Biology, 2023 The coexistence of two pools of ATP synthase in mitochondria has been largely neglected despite in vitro indications for the existence of reversible active/inactive state transitions in the F1-domain of the enzyme.
Inés Romero-Carramiñana +4 more
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