Results 11 to 20 of about 837,065 (393)
The persistent homology of mitochondrial ATP synthases
iScience, 2023 Summary: Relatively little is known about ATP synthase structure in protists, and the investigated ones exhibit divergent structures distinct from yeast or animals.
Savar D. Sinha, Jeremy G. Wideman
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Impaired ATP Synthase Assembly Associated with a Mutation in the Human ATP Synthase Subunit 6 Gene [PDF]
Journal of Biological Chemistry, 2001 Mutations in human mitochondrial DNA are a well recognized cause of disease. A mutation at nucleotide position 8993 of human mitochondrial DNA, located within the gene for ATP synthase subunit 6, is associated with the neurological muscle weakness, ataxia, and retinitis pigmentosa (NARP) syndrome.
Leo G.J. Nijtmans +4 more
openaire +10 more sources
The role of mitochondrial ATP synthase in cancer [PDF]
Biological Chemistry, 2020 The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner mitochondrial membrane which is essential for oxidative phosphorylation under physiological conditions.
Chiara Galber +3 more
semanticscholar +5 more sources
ATP synthase evolution on a cross-braced dated tree of life
bioRxiv, 2023 The timing of early cellular evolution from the divergence of Archaea and Bacteria to the origin of eukaryotes remains poorly constrained. The ATP synthase complex is thought to have originated prior to the Last Universal Common Ancestor (LUCA) and ...
T. Mahendrarajah +10 more
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Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis
Journal of Global Antimicrobial Resistance, 2022 : The ATP synthase is a multicomponent enzyme that is largely conserved across the kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by using the electrochemical proton gradient generated via the electron transport ...
Martin Vestergaard +2 more
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EMBO Journal, 2023 Mycobacteria, such as Mycobacterium tuberculosis, depend on the activity of adenosine triphosphate (ATP) synthase for growth. The diarylquinoline bedaquiline (BDQ), a mycobacterial ATP synthase inhibitor, is an important medication for treatment of drug ...
G. M. Courbon +5 more
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Autoantibodies to endothelial cell surface ATP synthase, the endogenous receptor for hsp60, might play a pathogenic role in vasculatides. [PDF]
PLoS ONE, 2011 BACKGROUND: Heat shock protein (hsp) 60 that provides "danger signal" binds to the surface of resting endothelial cells (EC) but its receptor has not yet been characterized. In mitochondria, hsp60 specifically associates with adenosine triphosphate (ATP)
Jean-Eric Alard +6 more
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Antibiotics, 2021 The ATP synthase has been validated as a druggable target with the approval of the ATP synthase inhibitor, bedaquiline, for treatment of drug-resistant Mycobacterium tuberculosis, a bacterial species in which the ATP synthase is essential for viability ...
Martin Vestergaard +2 more
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Communications Biology, 2023 The coexistence of two pools of ATP synthase in mitochondria has been largely neglected despite in vitro indications for the existence of reversible active/inactive state transitions in the F1-domain of the enzyme.
Inés Romero-Carramiñana +4 more
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Structure of ATP synthase under strain during catalysis
Nature Communications, 2022 ATP synthases are macromolecular machines consisting of an ATP-hydrolysis-driven F1 motor and a proton-translocation-driven FO motor. The F1 and FO motors oppose each other’s action on a shared rotor subcomplex and are held stationary relative to each ...
Hui Guo, J. Rubinstein
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