Results 11 to 20 of about 165,086 (247)

Reversible Thiol Oxidation Inhibits the Mitochondrial ATP Synthase in Xenopus Laevis Oocytes

Antioxidants, 2020
Oocytes are postulated to repress the proton pumps (e.g., complex IV) and ATP synthase to safeguard mitochondrial DNA homoplasmy by curtailing superoxide production. Whether the ATP synthase is inhibited is, however, unknown.
James Cobley, Anna Noble, Rachel Bessell, Matthew Guille, Holger Husi   +4 more
doaj   +1 more source

Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients

Molecules, 2023
Polyphenols have attracted attention in the fight against antibiotic-resistant bacteria, as they show antibacterial action. Considering that polyphenols inhibit F1Fo-ATP synthase (ATP synthase) and that bacteria need a constant energy production to ...
Silvia Ravera, Gabriele Tancreda, Luigi Vezzulli, Anna Maria Schito, Isabella Panfoli   +4 more
doaj   +1 more source

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

Cell Death and Disease, 2023
ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly variable.
Sonia Domínguez-Zorita, Inés Romero-Carramiñana, Fulvio Santacatterina, Pau B. Esparza-Moltó, Carolina Simó, Araceli del-Arco, Cristina Núñez de Arenas, Jorge Saiz, Coral Barbas, José M. Cuezva   +9 more
doaj   +1 more source

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites.
Brad Ebanks, Lisa Chakrabarti, Lisa Chakrabarti   +2 more
doaj   +1 more source

Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. [PDF]

PLoS ONE, 2017
Reduced cellular ATP synthesis due to impaired mitochondrial function of immune cells may be a factor influencing the immune response in septic shock. We investigate changes in mitochondrial function and bioenergetics of human monocytes and lymphocyte ...
Tobias M Merz, Adriano J Pereira, Roger Schürch, Joerg C Schefold, Stephan M Jakob, Jukka Takala, Siamak Djafarzadeh   +6 more
doaj   +1 more source

GaMF1.39’s antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876

Microbiology Spectrum, 2023
The Mycobacterium tuberculosis (Mtb) F-ATP synthase generates most of the biological energy currency ATP. Previously, we identified the mycobacterium-specific loop of the F-ATP synthase subunit γ as a new anti-tuberculosis target and discovered the novel
Priya Ragunathan, Pearly Shuyi Ng, Samsher Singh, Wee Han Poh, Dennis Litty, Nitin Pal Kalia, Simon Larsson, Amaravadhi Harikishore, Scott A. Rice, Philip W. Ingham, Volker Müller, Garrett Moraski, Marvin J. Miller, Thomas Dick, Kevin Pethe, Gerhard Grüber   +15 more
doaj   +1 more source

Targeting the ATP synthase in bacterial and fungal pathogens: beyond Mycobacterium tuberculosis

Journal of Global Antimicrobial Resistance, 2022
: The ATP synthase is a multicomponent enzyme that is largely conserved across the kingdoms of life. In many species the ATP synthase is central in the synthesis of ATP by using the electrochemical proton gradient generated via the electron transport ...
Martin Vestergaard, Dirk Bald, Hanne Ingmer   +2 more
doaj  

ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria

Frontiers in Molecular Biosciences, 2023
It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix probing into the central architecture of the ...
Alexander Krah, Alexander Krah, Timothy Vogelaar, Sam I. de Jong, Jolyon K. Claridge, Peter J. Bond, Peter J. Bond, Duncan G. G. McMillan, Duncan G. G. McMillan   +8 more
doaj   +1 more source

Thymoquinone Inhibits Escherichia coli ATP Synthase and Cell Growth. [PDF]

PLoS ONE, 2015
We examined the thymoquinone induced inhibition of purified F1 or membrane bound F1FO E. coli ATP synthase. Both purified F1 and membrane bound F1FO were completely inhibited by thymoquinone with no residual ATPase activity. The process of inhibition was
Zulfiqar Ahmad, Thomas F Laughlin, Ismail O Kady   +2 more
doaj   +1 more source

Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium

Frontiers in Plant Science, 2015
The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts.
Abir U Igamberdiev, Leszek A Kleczkowski
doaj   +1 more source