Results 21 to 30 of about 837,065 (393)
Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex
Cell Death and Differentiation, 2022 Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was suggested to house the leak channel of mitochondrial permeability transition (mPT), which activates during
N. Mnatsakanyan +12 more
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The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation
Cell Death and Differentiation, 2022 Binding of the mitochondrial chaperone TRAP1 to client proteins shapes bioenergetic and proteostatic adaptations of cells, but the panel of TRAP1 clients is only partially defined.
G. Cannino +14 more
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Defueling the cancer: ATP synthase as an emerging target in cancer therapy
Molecular Therapy: Oncolytics, 2021 Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in ...
Ting Wang, Fei Ma, Hai-li Qian
doaj +1 more source
Scientific Reports, 2023 The mitochondrial ATP synthase, an enzyme that synthesizes ATP and is involved in the formation of the mitochondrial mega-channel and permeability transition, is a multi-subunit complex. In S.
Chiranjit Panja +4 more
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ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria
Nature Communications, 2021 Mitochondrial ATP synthase plays a key role in inducing membrane curvature to establish cristae. In Apicomplexa causing diseases such as malaria and toxoplasmosis, an unusual cristae morphology has been observed, but its structural basis is unknown. Here,
Alexander Mühleip +6 more
semanticscholar +1 more source
Human F1F0 ATP synthase, mitochondrial ultrastructure and OXPHOS impairment: a (super-)complex matter? [PDF]
PLoS ONE, 2013 Mitochondrial morphogenesis is a key process of cell physiology. It is essential for the proper function of this double membrane-delimited organelle, as it ensures the packing of the inner membrane in a very ordered pattern called cristae.
Johann Habersetzer +6 more
doaj +1 more source
Journal of Clinical Investigation, 2021 Emerging evidence has shown that open reading frames inside lncRNA could encode micropeptides. However, their roles in cellular energy metabolism and tumor progression remain largely unknown.
Qiwei Ge +11 more
semanticscholar +1 more source
Mitochondrial F-ATP Synthase Co-Migrating Proteins and Ca2+-Dependent Formation of Large Channels
Cells, 2023 Monomers, dimers, and individual FOF1-ATP synthase subunits are, presumably, involved in the formation of the mitochondrial permeability transition pore (PTP), whose molecular structure, however, is still unknown.
Anna B. Nikiforova +8 more
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Nature Communications, 2021 F-ATP synthase is a leading candidate as the mitochondrial permeability transition pore (PTP) but the mechanism(s) leading to channel formation remain undefined.
Andrea Carrer +10 more
semanticscholar +1 more source
Mitochondrial F1FO ATP synthase determines the local proton motive force at cristae rims
EMBO Reports, 2021 The classical view of oxidative phosphorylation is that a proton motive force (PMF) generated by the respiratory chain complexes fuels ATP synthesis via ATP synthase.
Bettina Rieger +4 more
semanticscholar +1 more source