Results 21 to 30 of about 165,086 (247)

Identification of cryptic subunits from an apicomplexan ATP synthase

eLife, 2018
The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex.
Diego Huet, Esther Rajendran, Giel G van Dooren, Sebastian Lourido   +3 more
doaj   +1 more source

The mitochondrial Hsp70 controls the assembly of the F1FO-ATP synthase

Nature Communications, 2023
The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.
Jiyao Song, Liesa Steidle, Isabelle Steymans, Jasjot Singh, Anne Sanner, Lena Böttinger, Dominic Winter, Thomas Becker   +7 more
doaj   +1 more source

Structure, Regulation, and Significance of Cyanobacterial and Chloroplast Adenosine Triphosphate Synthase in the Adaptability of Oxygenic Photosynthetic Organisms

Microorganisms
In cyanobacteria and chloroplasts (in algae and plants), ATP synthase plays a pivotal role as a photosynthetic membrane complex responsible for producing ATP from adenosine diphosphate and inorganic phosphate, utilizing a proton motive force gradient ...
Siyan Yi, Xin Guo, Wenjing Lou, Shaoming Mao, Guodong Luan, Xuefeng Lu   +5 more
doaj   +1 more source

Defueling the cancer: ATP synthase as an emerging target in cancer therapy

Molecular Therapy: Oncolytics, 2021
Reprogramming of cellular metabolism is a hallmark of cancer. Mitochondrial ATP synthase (MAS) produces most of the ATP that drives the cell. High expression of the MAS-composing proteins is found during cancer and is linked to a poor prognosis in ...
Ting Wang, Fei Ma, Hai-li Qian
doaj  

The F1Fo-ATP synthase α subunit of Candida albicans induces inflammatory responses by controlling amino acid catabolism

Virulence, 2023
Sepsis is a leading cause of fatality in invasive candidiasis. The magnitude of the inflammatory response is a determinant of sepsis outcomes, and inflammatory cytokine imbalances are central to the pathophysiological processes.
Shuixiu Li, Yuting Liu, Luobei Weng, Yajing Zhao, Yishan Zhang, Zhanpeng Zhang, Yang Yang, Qiaoxin Chen, Xiaocong Liu, Hong Zhang   +9 more
doaj   +1 more source

High-Conductance Channel Formation in Yeast Mitochondria is Mediated by F-ATP Synthase e and g Subunits

Cellular Physiology and Biochemistry, 2018
Background/Aims: The permeability transition pore (PTP) is an unselective, Ca2+-dependent high conductance channel of the inner mitochondrial membrane whose molecular identity has long remained a mystery. The most recent hypothesis is that pore formation
Michela Carraro, Vanessa Checchetto, Geppo Sartori, Roza Kucharczyk, Jean-Paul di Rago, Giovanni Minervini, Cinzia Franchin, Giorgio Arrigoni, Valentina Giorgio, Valeria Petronilli, Silvio C.E. Tosatto, Giovanna Lippe, Ildikó Szabó, Paolo Bernardi   +13 more
doaj   +1 more source

Spatial and temporal dynamics of ATP synthase from mitochondria toward the cell surface

Communications Biology, 2023
Ectopic ATP synthase complex (eATP synthase), located on cancer cell surface, has been reported to possess catalytic activity that facilitates the generation of ATP in the extracellular environment to establish a suitable microenvironment and to be a ...
Yi-Wen Chang, T. Tony Yang, Min-Chun Chen, Y-geh Liaw, Chieh-Fan Yin, Xiu-Qi Lin-Yan, Ting-Yu Huang, Jen-Tzu Hou, Yi-Hsuan Hung, Chia-Lang Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan   +11 more
doaj   +1 more source

Understanding structure, function, and mutations in the mitochondrial ATP synthase

Microbial Cell, 2015
The mitochondrial ATP synthase is a multimeric enzyme complex with an overall molecular weight of about 600,000 Da. The ATP synthase is a molecular motor composed of two separable parts: F1 and Fo. The F1 portion contains the catalytic sites for ATP
Ting Xu, Vijayakanth Pagadala, David M. Mueller   +2 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

Nature Communications, 2016
F1FO ATP synthase is a critical enzyme for the maintenance of mitochondrial function. Here the authors demonstrate that loss of the F1FO-ATP synthase subunit OSCP and the interaction of OSCP with Aβ peptide in Alzheimer’s disease patients and mouse ...
Simon J. Beck, Lan Guo, Aarron Phensy, Jing Tian, Lu Wang, Neha Tandon, Esha Gauba, Lin Lu, Juan M. Pascual, Sven Kroener, Heng Du   +10 more
doaj   +1 more source