Results 21 to 30 of about 329,086 (345)

A new type of Na+-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif [PDF]

, 2013
: The anaerobic bacterium Fusobacterium nucleatum uses glutamate decarboxylation to generate a transmembrane gradient of Na+. Here, we demonstrate that this ion-motive force is directly coupled to ATP synthesis, via an F1Fo-ATP synthase with a novel Na ...
Faraldo-Gómez, José D., Iglesias-Cans, Marina, Krah, Alexander, Leone, Vanessa, M. Cook, Gregory, Matthies, Doreen, Meier, Thomas, Schulz, Sarah, Yildiz, Özkan   +8 more
core   +3 more sources

Cirsiliol and Quercetin Inhibit ATP Synthesis and Decrease the Energy Balance in Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Resistant Staphylococcus epidermidis (MRSE) Strains Isolated from Patients

Molecules, 2023
Polyphenols have attracted attention in the fight against antibiotic-resistant bacteria, as they show antibacterial action. Considering that polyphenols inhibit F1Fo-ATP synthase (ATP synthase) and that bacteria need a constant energy production to ...
Silvia Ravera, Gabriele Tancreda, Luigi Vezzulli, Anna Maria Schito, Isabella Panfoli   +4 more
doaj   +1 more source

IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype

Cell Death and Disease, 2023
ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP synthase. The expression of IF1 in differentiated human and mouse cells is highly variable.
Sonia Domínguez-Zorita, Inés Romero-Carramiñana, Fulvio Santacatterina, Pau B. Esparza-Moltó, Carolina Simó, Araceli del-Arco, Cristina Núñez de Arenas, Jorge Saiz, Coral Barbas, José M. Cuezva   +9 more
doaj   +1 more source

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases

Frontiers in Molecular Biosciences, 2022
The mitochondrial ATP synthase is responsible for the production of cellular ATP, and it does so by harnessing the membrane potential of the mitochondria that is produced by the sequential oxidation of select cellular metabolites.
Brad Ebanks, Lisa Chakrabarti, Lisa Chakrabarti   +2 more
doaj   +1 more source

36 degree step size of proton-driven c-ring rotation in FoF1-ATP synthase [PDF]

, 2009
Synthesis of the biological "energy currency molecule" adenosine triphosphate ATP is accomplished by FoF1-ATP synthase. In the plasma membrane of Escherichia coli, proton-driven rotation of a ring of 10 c subunits in the Fo motor powers catalysis in the ...
Boersch, Michael, Cipriano, Daniel J., Dueser, Monika G., Dunn, Stanley D., Ernst, Stefan, Glick, Gary D., Zarrabi, Nawid   +6 more
core   +2 more sources

Optimization of ATP synthase function in mitochondria and chloroplasts via the adenylate kinase equilibrium

Frontiers in Plant Science, 2015
The bulk of ATP synthesis in plants is performed by ATP synthase, the main bioenergetics engine of cells, operating both in mitochondria and in chloroplasts.
Abir U Igamberdiev, Leszek A Kleczkowski
doaj   +1 more source

Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. [PDF]

PLoS ONE, 2017
Reduced cellular ATP synthesis due to impaired mitochondrial function of immune cells may be a factor influencing the immune response in septic shock. We investigate changes in mitochondrial function and bioenergetics of human monocytes and lymphocyte ...
Tobias M Merz, Adriano J Pereira, Roger Schürch, Joerg C Schefold, Stephan M Jakob, Jukka Takala, Siamak Djafarzadeh   +6 more
doaj   +1 more source

ATP binding by an F1Fo ATP synthase ε subunit is pH dependent, suggesting a diversity of ε subunit functional regulation in bacteria

Frontiers in Molecular Biosciences, 2023
It is a conjecture that the ε subunit regulates ATP hydrolytic function of the F1Fo ATP synthase in bacteria. This has been proposed by the ε subunit taking an extended conformation, with a terminal helix probing into the central architecture of the ...
Alexander Krah, Alexander Krah, Timothy Vogelaar, Sam I. de Jong, Jolyon K. Claridge, Peter J. Bond, Peter J. Bond, Duncan G. G. McMillan, Duncan G. G. McMillan   +8 more
doaj   +1 more source

MITOCHONDRIAL ATP SYNTHASE

Journal of the Grodno State Medical University, 2020
In the following review we collected and analyzed the currently available data on the structure and organization, localization, working mechanisms and functions of a universal and unique in its characteristics enzyme of ATP synthesis – ATP synthase. In addition to synthase and hydrolase activity, associated into dimers mitochondrial ATP synthase is ...
E. V. Uzlova, S. M. Zimatkin
openaire   +2 more sources

Structure of the ATP-Synthase from Chloroplasts and Mitochondria Studied by Electron Microscopy [PDF]

, 1988
The structure of the ATP-synthase, F0F1 , from spinach chloroplasts and beef heart mitochondria has been investigated by electron microscopy with negatively stained specimens.
Berden, Jan A., Boekema, Egbert J., Gräber, Peter, Schmidt, Günter   +3 more
core   +1 more source