Results 11 to 20 of about 98,797 (266)
ATR activation is regulated by dimerization of ATR activating proteins [PDF]
Journal of Biological Chemistry, 2021 The checkpoint kinase ATR regulates DNA repair, cell cycle progression, and other DNA damage and replication stress responses. ATR signaling is stimulated by an ATR activating protein, and in metazoan cells, there are at least two ATR activators: TOPBP1 and ETAA1.
Vaughn Thada, David Cortez
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Current Biology, 2003 What are ATM and ATR? Ataxia telangiectasia mutated (ATM) and ATM and RAD3-related (ATR) are members of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases (PIKKs). These large proteins – predicted molecular masses for ATM and ATR are 351kDa and 301kDa, respectively – are involved in cellular responses to DNA damage.Don't ...
Bradbury, Jane M., Jackson, Stephen P.
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ATR signaling at a glance [PDF]
Journal of Cell Science, 2009 The maintenance of genomic integrity is crucial for the survival of all organisms. In humans, compromised genomic integrity contributes to genetic disorders, aging and cancers. The task of safeguarding the genome is accomplished by the concerted action of a number of cellular processes ...
Bunsyo, Shiotani, Lee, Zou
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Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA [PDF]
Nature Communications, 2018 AbstractATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss. Mouse model expressing kinase-dead ATR (Atr+/KD), but not loss of ATR (Atr+/−), displays ssDNA-dependent defects at the non-homologous region of X-Y chromosomes during male meiosis ...
Demis Menolfi +8 more
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Discriminative sparsity for Sonar ATR [PDF]
OCEANS 2015 - MTS/IEEE Washington, 2015 Advancements in Sonar image capture have enabled researchers to apply sophisticated object identification algorithms in order to locate targets of interest in images such as mines. Despite progress in this field, modern sonar automatic target recognition (ATR) approaches lack robustness to the amount of noise one would expect in real-world scenarios ...
John McKay 0002 +3 more
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Real-Time, On-Site, Machine Learning Identification Methodology of Intrinsic Human Cancers Based on Infra-Red Spectral Analysis – Clinical Results [PDF]
Journal of Systemics, Cybernetics and Informatics, 2020 In this work we present a real-time (RT), on-site, machine-learning based methodology for identifying intrinsic human cancers. The presented approach is reliable, effective, cost-effective and non-invasive and based on the Fourier transform infrared ...
Yaniv Cohen +3 more
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Turkish Journal of Agriculture: Food Science and Technology, 2023 Microorganisms have various stress response systems to maintain their viability when exposed to different stress conditions. In this study, Lactobacillus acidophilus ATCC 4356 and Bifidobacterium bifidum ATCC 11863 strains, used in probiotic yoghurt ...
Şehriban Oğuz +3 more
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, 2023 R scripts used in the publication for the analysis of the phospho-proteomics dataset.
Jadav, Rathan S +2 more
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Carcinogenesis in Ulcerative Colitis: Is Surveillance Worthwhile?
Canadian Journal of Gastroenterology, 1990 Observations that dysplastic epithelium predicts neoplastic change in the coli tic bowel have led to the adoption of surveillance policies in ulcerative colitis patients, usually involving colonoscopy irrespective of symptomatology.
ATR Axon
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Historical Documents and Automatic Text Recognition: Introduction [PDF]
Journal of Data Mining and Digital HumanitiesWith this special issue of the Journal of Data Mining and Digital Humanities (JDMDH), we bringtogether in one single volume several experiments, projects and reflections related to automatic textrecognition applied to historical documents.
Ariane Pinche, Peter Stokes
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