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Atypical chemokine receptors in the immune system

Nature Reviews Immunology
Leukocyte migration is a fundamental component of innate and adaptive immune responses as it governs the recruitment and localization of these motile cells, which is crucial for immune cell priming, effector functions, memory responses and immune regulation.
Iain Comerford, Shaun R. McColl
openaire   +2 more sources

Regulation of Breast Cancer Metastasis by Atypical Chemokine Receptors

Clinical Cancer Research, 2009
Abstract The interaction between chemokines and their G-protein-coupled receptors plays an important role in promoting metastasis of different kinds of human cancers. However, the expression of an atypical chemokine receptor, CCX-CKR, which serves as a decoy receptor to attract chemokines, inhibits the growth and metastasis of breast ...
Xiaoyun, Cheng, Mien-Chie, Hung
openaire   +2 more sources

The biochemistry and biology of the atypical chemokine receptors

Immunology Letters, 2012
A subset of chemokine receptors, initially called "silent" on the basis of their apparent failure to activate conventional signalling events, has recently attracted growing interest due to their ability to internalize, degrade, or transport ligands and thus modify gradients and create functional chemokine patterns in tissues.
G. J. Graham   +4 more
openaire   +3 more sources

Contribution of atypical chemokine receptor 2/ackr2 in bone remodeling

Bone, 2017
Bone remodeling is a tightly regulated process influenced by chemokines. ACKR2 is a decoy receptor for CC chemokines functioning as regulator of inflammatory response. In this study we investigated whether the absence of ACKR2 would affect bone phenotype and remodeling induced by mechanical loading.An orthodontic appliance was placed between incisors ...
Izabella Lucas de Abreu, Lima   +9 more
openaire   +2 more sources

Atypical Chemokine Receptors

2016
Raffaella Bonecchi   +2 more
openaire   +1 more source

Atypical Chemokine Receptors

Raffaella Bonecchi   +2 more
openaire   +1 more source

Role of atypical chemokine receptor 2 in hypertension

Atherosclerosis
Tomasz Mikolajczyk   +13 more
openaire   +1 more source

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