Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment. [PDF]
, 2017 CXCR1 and CXCR2 chemokine receptors and their ligands (CXCL1/2/3/7/8) play an important role in tumor progression. Tested to date CXCR1/2 antagonists and chemokine-targeted antibodies were reported to affect malignant cells in vitro and in animal models.
Alexeev, Vitali +10 more
core +2 more sources
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
core +2 more sources
Atypical chemokine receptor 2: a brake against Kaposi's sarcoma aggressiveness [PDF]
OncoImmunology, 2014 Inflammatory chemokines are instrumental players in cancer-related inflammation contributing to numerous steps during tumor progression. In Kaposi's sarcoma, we have found that downregulation of the atypical chemokine receptor 2 (ACKR2) by the KRAS/BRAF/ERK pathway profoundly affects the tumor microenvironment, unleashing accumulation of tumor ...
Bonecchi R. +5 more
openaire +3 more sources
CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]
, 2017 The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian +17 more
core +1 more source
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization [PDF]
Frontiers in Aging Neuroscience, 2017 Inflammatory reactions occurring in the central nervous system (CNS), known as neuroinflammation, are key components of the pathogenic mechanisms underlying several neurological diseases. The chemokine system plays a crucial role in the recruitment and activation of immune and non-immune cells in the brain, as well as in the regulation of microglia ...
Valentina Salvi +6 more
openaire +5 more sources
The Role of Atypical Chemokine Receptor CCXCKR (CCRL1) in Human Diseases [PDF]
International Journal of Basic Science in Medicine, 2016 The role of chemokines and their receptors have been identified in many biological activities such as immune response and angiogenesis; however, their regulatory ways are under investigation.
Parvin Salimi, Abolghasem Esmaeili
doaj +1 more source
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]
, 2019 Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra +13 more
core +1 more source
Atypical chemokine receptors in cancer
CytokineAtypical chemokine receptors (ACKRs) are a group of seven-transmembrane spanning serpentine receptors that are structurally homologous to classical G-protein-coupled receptors and bind cognate chemokines with high affinities but do not signal via G-proteins or mediate cell migration.
Maryna Samus, Antal Rot
openaire +2 more sources
Human Genomics, 2019 Background Age-related macular degeneration (AMD) is the most common, progressive, and polygenic cause of irreversible visual impairment in the world. The molecular pathogenesis of the primary events of AMD is poorly understood.
Madhu Sudhana Saddala +5 more
doaj +1 more source
Cells, 2022 Atypical chemokine receptors (ACKRs) have emerged as a subfamily of chemokine receptors regulating the local bioavailability of their ligands through scavenging, concentration, or transport.
Gaetan-Nagim Degroot +3 more
doaj +1 more source