Results 191 to 200 of about 29,540 (247)
International Journal of Molecular Sciences, 2020 Autoantigen treatment has been tried for the prevention of type 1 diabetes (T1D) and to preserve residual beta-cell function in patients with a recent onset of the disease.
Johnny Ludvigsson, Ludvigsson Johnny
exaly +2 more sources
Identification of α-enolase as an autoantigen associated with severe asthma
Journal of Allergy and Clinical Immunology, 2006 BACKGROUND: Approximately 5% to 10% of patients with asthma have severe disease that is not effectively controlled by typical therapies. The existence of an autoantigen associated with severe asthma has been previously reported.
Dong-Ho Nahm +2 more
exaly +3 more sources
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Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens
Journal of Proteome Research, 2023Understanding autoimmunity to endogenous proteins is crucial in diagnosing and treating autoimmune diseases. In this work, we developed a user-friendly AAgAtlas portal (http://biokb.ncpsb.org.cn/aagatlas_portal/index.php#), which can be used to search for 8045 non-redundant autoantigens (AAgs) and 47 post-translationally modified AAgs against 1073 ...
Dan Wang +20 more
openaire +2 more sources
What Makes an Autoantigen an Autoantigen?
Annals of the New York Academy of Sciences, 2005Abstract: Multiple classes of proteins are modified to tailor them for specific physiological roles. The nature of these posttranslational modifications of proteins, as well as the relationships between them including those of the immune system proteins themselves, and immune system responses are reviewed.
Chih-Te, Wu +2 more
openaire +2 more sources
Autoimmunity Reviews, 2002
Autoimmune diseases frequently manifest themselves in fulminating immune reactions involving T and B cells that lead to the appearance of circulating autoantibodies. Such antibodies are considered to be of diagnostic relevance and may be pathognomonic for their associated autoimmune diseases.
J, Schmitt, W, Papisch
openaire +2 more sources
Autoimmune diseases frequently manifest themselves in fulminating immune reactions involving T and B cells that lead to the appearance of circulating autoantibodies. Such antibodies are considered to be of diagnostic relevance and may be pathognomonic for their associated autoimmune diseases.
J, Schmitt, W, Papisch
openaire +2 more sources
Nature Medicine, 2007
Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of
Nishie, Wataru +11 more
openaire +5 more sources
Transmissibility of characteristic lesions to experimental animals may help us understand the pathomechanism of human autoimmune disease. Here we show that human autoimmune disease can be reproduced using genetically engineered model mice. Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of
Nishie, Wataru +11 more
openaire +5 more sources
Molecular Biology Reports, 1996
The major cellular antigens recognized by autoantibodies in SLE and other systemic autoimmune diseases have been identified and characterized over the past 25 years. The pioneering studies of Eng Tan demonstrate the importance of autoantibodies as diagnostic markers.
W H, Reeves, M, Satoh
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The major cellular antigens recognized by autoantibodies in SLE and other systemic autoimmune diseases have been identified and characterized over the past 25 years. The pioneering studies of Eng Tan demonstrate the importance of autoantibodies as diagnostic markers.
W H, Reeves, M, Satoh
openaire +2 more sources