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Journal of Autoimmunity, 2015 ‘Autoantigen complementarity’ is a theory proposing that the initiator of an autoimmune response is not necessarily the autoantigen or its molecular mimic, but may instead be a peptide that is ‘antisense/complementary’ to the autoantigen. We investigated
Gloria A Preston +2 more
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The role of autoantigen in autoimmunity
Immunology Letters, 1987Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells.
I M Roitt, Anne Cooke
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Characterization of the autoantigen calreticulin
The Journal of Immunology, 1991Abstract Anti-Ro/SS-A antibodies are commonly found in the sera of patients with Sjögren’s syndrome and SLE. These antibodies also occur in the mothers of children with neonatal lupus and congenital heart block. Ro/SS-A is a ribonucleoprotein complex whose cellular function remains unknown.
L A, Rokeach +6 more
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GAD65 as a prototypic autoantigen
Journal of Autoimmunity, 2008The repertoire of known autoantigens is limited to a very small proportion of all human proteins, and the reason why only some proteins become autoantigens is unclear, but is likely associated with structural features. The 65kDa isoform of the enzyme glutamic acid decarboxylase (GAD65) is a major autoantigen in type I diabetes, and in various ...
Gustavo, Fenalti, Merrill J, Rowley
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Thyroid Peroxidase as an Autoantigen
Thyroid, 2007Thyroid peroxidase (TPO) evokes high-affinity, IgG-class autoantibodies [TPO autoantibodies (TPOAbs)] and TPO-specific T cells that are markers of thyroid infiltration or implicated in thyroid destruction, respectively. A diverse repertoire of human monoclonal TPOAbs, unparalleled in other autoimmune diseases, provides invaluable probes for ...
Sandra M, McLachlan, Basil, Rapoport
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Autoantigens in thyroid diseases
Springer Seminars in Immunopathology, 1993The autoantigens involved in autoimmune thyroid disease have now been extensively characterised, and the autoantibodies they evoke provide important aids to diagnosis, leading to early treatment of thyroid autoimmunity. The next stage in the puzzle is to determine towards which epitopes on the autoantigens the immune response is directed.
K, Dawe +4 more
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Tolerance in the Absence of Autoantigen
Endocrine‚ Metabolic & Immune Disorders-Drug Targets, 2007Regulatory T (T(reg)) cells show promise for treating autoimmune diseases, but their induction to elevated potency has been problematic when the most optimally derived cells are from diseased animals. To circumvent reliance on auto-antigen reactive T(reg) cells, stimulation to vaccine antigens (Ags) may offer a viable alternative while maintaining ...
D W, Pascual +3 more
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Ubiquitination of Ro52 autoantigen
Biochemical and Biophysical Research Communications, 2002Anti-Ro/SSA antibodies are antinuclear antibodies most commonly found in patients with Sjögren's syndrome, a chronic autoimmune disease characterized by dryness of the eyes and mouth. The autoantibodies recognize a RING-finger protein, Ro52/SSA (52 kDa), whose function is still unknown. In this study, the ubiquitination of Ro52 was investigated.
Taeko, Fukuda-Kamitani, Tetsu, Kamitani
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Golgi Autoantibodies and Autoantigens
Journal of Autoimmunity, 1994Autoantibodies directed against cellular constituents rarely react with antigens localized in the Golgi apparatus and little information is available regarding these particular antibodies. Although thousands of samples have been examined for autoantibodies in our laboratory on a routine basis, only three human sera with anti-Golgi antibodies could be ...
G, Renier +7 more
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Autoantigens in an immunological network
Medical Hypotheses, 1983An autoantigen network, consisting of all non-lymphoid cells and a subset of peripherally located autoregulatory lymphocytes, is proposed. By equilibrating a web of idiotypic stimulation (helper activity) and antiidiotypic inhibition (suppressor activity) directed at each tissue differentiation antigen, this network quantitatively limits autoantigen ...
F T, Vertosick, R H, Kelly
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