Results 111 to 120 of about 59,330 (297)

Bullous Pemphigoid Presenting as Immunoglobulin M Pemphigoid

JEADV Clinical Practice, EarlyView.
D. Didona, R. Maglie, A. M. Sequeira Santos, V. Schwarz, M. Hertl, F. Solimani   +5 more
wiley   +1 more source

Efficacy of IDOR‐1117‐2520, a novel, orally available CCR6 antagonist in preclinical models of skin dermatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose The chemokine receptor CCR6 guides pathogenic T17 cells, implicated in autoimmune diseases including psoriasis, to sites of inflammation via the chemokine CCL20. Therefor, pharmacological inhibition of CCR6+ immune cell migration provides a novel therapeutic approach.
Paulina Kulig, Pijus Brazauskas, Madeleine Suffiotti, Emilie Raoult, Ulrike Babilonski, Bérengère Renault, Ursula Grieder, Enrico Vezzali, Peter Blattmann, Marianne M. Martinic, Mark J. Murphy   +10 more
wiley   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, EarlyView.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

Morbid Sequences Suggest Molecular Mimicry between Microbial Peptides and Self-Antigens: A Possibility of Inciting Autoimmunity

Frontiers in Microbiology, 2017
Understanding etiology of autoimmune diseases has been a great challenge for designing drugs and vaccines. The pathophysiology of many autoimmune diseases may be attributed to molecular mimicry provoked by microbes.
Susanta Pahari, Susanta Pahari, Deepyan Chatterjee, Shikha Negi, Jagdeep Kaur, Balvinder Singh, Javed N. Agrewala   +6 more
doaj   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

Impact of Lymphocyte Apoptosis in Diabetes mellitus

Asian Journal of Medical Sciences, 2011
Diabetes mellitus is a metabolic disorder. It is the most common cause of blindness, kidney failure, and amputations in adults and a leading cause of heart disease and stroke.
Awadhesh K Arya
doaj   +1 more source

Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS [PDF]

, 2012
Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia ...
Wanchung(Wan-Jiung) Hu
core   +1 more source

Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies

Journal of Experimental Medicine, 2013
Immunological tolerance to self-antigen impairs humoral responses to HIV-1.
Guang Yang, T. Holl, Yang Liu, Yi Li, Xiaozhi Lu, N. Nicely, T. Kepler, S. Munir Alam, H. Liao, D. Cain, L. Spicer, J. L. VandeBerg, B. Haynes, G. Kelsoe   +13 more
semanticscholar   +1 more source

Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]

, 2019
Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R., Lieberman, Scott M., Morthen, Mathias Kaurstad, Rahimi Darabad, Raheleh, Richards, Stephen M., Sullivan, David A., Tellefsen, Sara   +6 more
core   +1 more source

Establishing the performance and acceptability of dried blood spot sampling to screen for islet‐specific autoantibodies

Diabetic Medicine, EarlyView.
This comprehensive validation and acceptability study shows dried blood spot sampling can be used as an alternative to serum for use with the 3‐screen assay for population type 1 diabetes autoantibody screening and appears acceptable to parents and stakeholders.
Siân E. Faustini, Lauren M. Quinn, Madeeha Hoque, Siobhan Young, Christopher Bentley, Hin‐Fai Kwok, Timothy Plant, Ian Litchfield, Felicity Boardman, Sheila M. Greenfield, Parth Narendran, Alex G. Richter   +11 more
wiley   +1 more source