Results 61 to 70 of about 5,861,967 (293)

A Synthesis of Algorithms Determining a Safe Trajectory in a Group of Autonomous Vehicles Using a Sequential Game and Neural Network

, 2023
This paper presents a solution to the problem of providing an autonomous vehicle with a safe control task when moving around many other autonomous vehicles.
Józef Lisowski
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Key Technologies and Standards of Autonomous Driving System Applied in Surface Mines

Kongzhi Yu Xinxi Jishu, 2019
The development and progress of autonomous driving technologies applied in surface mines was reviewed, the advantage resulted from the utilization of autonomous driving technologies in the mine operation was analyzed, the relevant standards were ...
ZHANG Tao, LU Xiangyang, LI Lei, QIN Xiaohui, LUAN Xiaofei   +4 more
doaj  

Adaptive State Feedback Shared Control for Unmanned Surface Vehicle With Fixed-Time Prescribed Performance Control

IEEE Access
Unmanned surface vehicles (USVs) often encounter unknown obstacles, adverse weather, and emergency situations during missions, especially external disturbances such as wind, waves, and ocean currents at sea, which pose challenges for operators to respond
Mengyue He, Chaobo Li, Hua Huang, Fangfang Zhou, Yuhang He, Wei Shang   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Autonomous Surface and Underwater Vehicles as Effective Ecosystem Monitoring and Research Platforms in the Arctic—The Glider Project

Sensors, 2021
Effective ocean management requires integrated and sustainable ocean observing systems enabling us to map and understand ecosystem properties and the effects of human activities.
Lionel Camus, Hector Andrade, Ana Sofia Aniceto, Magnus Aune, Kanchana Bandara, Sünnje Linnéa Basedow, Kai Håkon Christensen, Jeremy Cook, Malin Daase, Katherine Dunlop, Stig Falk-Petersen, Peer Fietzek, Gro Fonnes, Peygham Ghaffari, Geir Gramvik, Inger Graves, Daniel Hayes, Tor Langeland, Harald Lura, Trond Kristiansen, Ole Anders Nøst, David Peddie, Joel Pederick, Geir Pedersen, Ann Kristin Sperrevik, Kai Sørensen, Luca Tassara, Sigurd Tjøstheim, Vigdis Tverberg, Salve Dahle   +29 more
doaj   +1 more source

Vehicle to Infrastructure-Based LiDAR Localization Method for Autonomous Vehicles

, 2023
The localization of autonomous vehicles using light detection and ranging (LiDAR) sensors relies on high-definition (HD) maps, which are essential for accurate positioning.
Ohsung Kwon, Myeong-jun Kim, Jungha Kim
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source