Avenanthramide C mitigates cisplatin-induced hippocampal neurotoxicity and cognitive impairment in rats via suppression of neuroinflammation and neuronal apoptosis [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CP)-induced cognitive impairment, commonly referred to as chemobrain, affects a substantial proportion of patients with cancer and currently lacks an effective pharmacological treatment.
Maha Abdulrahman Aldubayan
doaj +4 more sources
Diversity of avenanthramide content in wild and cultivated oats [PDF]
Труды по прикладной ботанике, генетике и селекции, 2020 Background. Oat grains accumulate substantial amounts of various phenolic compounds that possess biological activity and have a potential to considerably increase health benefits of oats as a food.
S. Leonova +5 more
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Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer [PDF]
Acta Pharmaceutica Sinica BChemoresistance to 5-fluorouracil (5-FU) is a significant challenge in treating colorectal cancer (CRC). Novel combined regimens to thwart chemoresistance are therefore urgently needed.
Rong Fu +9 more
doaj +3 more sources
Avenanthramide C Prevents Neuronal Apoptosis via PI3K/Akt/GSK3β Signaling Pathway Following Middle Cerebral Artery Occlusion [PDF]
Brain Sciences, 2020 Avenanthramides are a group of phenolic alkaloids that have been shown to have anti-inflammatory, anti-oxidant, anti-atherogenic, and vasodilation effects.
Baoyuan Jin +4 more
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Avenanthramides, Distinctive Hydroxycinnamoyl Conjugates of Oat, Avena sativa L.: An Update on the Biosynthesis, Chemistry, and Bioactivities [PDF]
Plants, 2023 Avenanthramides are a group of N-cinnamoylanthranilic acids (phenolic alkaloid compounds) that are produced in oat plants as phytoalexins, in response to pathogen attack and elicitation.
Chanel J. Pretorius, Ian A. Dubery
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Avenanthramide supplementation reduces eccentric exercise-induced inflammation in young men and women [PDF]
Journal of the International Society of Sports Nutrition, 2020 Background Avenanthramides (AVA) are a group of di-phenolic acids found only in oats and have shown antioxidant and anti-inflammatory effects in vitro and in vivo.
Tianou Zhang +8 more
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Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway [PDF]
Frontiers in PharmacologyIntroductionCisplatin (CIS) is widely recognized as a potent antineoplastic agent, especially effective for treating various solid tumors. Nevertheless, the pathological response it induces, alongside oxidative stress and inflammation from upstream ...
Maha Abdulrahman Aldubayan
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Oat avenanthramide B alleviates high-fat diet-induced obesity via regulating fatty acid metabolism involved in gut bacteria and fungi remodeling [PDF]
Food Science and Human WellnessOat avenanthramides (AVNs) have been found to exhibit novel lipid-lowering effects. However, the mechanism remains unclear. In this study, the effect of avenanthramide B (AVN B), as one of the major AVNs, on high-fat diet (HFD)-induced mice was ...
Yongyong Liu +8 more
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Avenanthramide C Suppresses Matrix Metalloproteinase-9 Expression and Migration Through the MAPK/NF- κB Signaling Pathway in TNF-α-Activated HASMC Cells [PDF]
Frontiers in Pharmacology, 2021 In oat ingredients, flavonoids and phenolic acids are known to be the most important phenolic compounds. In phenolic compounds, wide-ranging biological responses, including antioxidative, anti-inflammatory, anti-allergic, and anti-cancer properties, were
Junyoung Park +10 more
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Avenanthramide-C as Alzheimer’s Disease-Modifying Therapy: Early and Sustained Intervention Prevents Disease Progression in Mouse Models [PDF]
CellsMost approved drugs for Alzheimer’s disease (AD) are indicated for early to moderate stages and primarily target amyloid-beta or neurotransmitter systems.
Alen Benhur Pravin Nathan +7 more
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