Cell Death and Disease, 2019 Colorectal cancer (CRC) is a common malignant gastrointestinal tumor with high mortality worldwide. Drug resistance and cytotoxicity to normal cells are the main causes of chemotherapeutic treatment failure in CRC.
Rong Fu +5 more
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Improved Chemical Synthesis of Avenanthramides Family and its Analogs by Mixed Anhydride Method
European Journal of Organic Chemistry, Volume 28, Issue 21, June 3, 2025.Valuable phytochemicals, including avenanthramides A, B, C, E, and some analogs, have been rapidly prepared as carbonate‐protected derivatives in acetone, achieving high yields by crystallization.. This process utilizes the mixed anhydride method with a triethylamine‐isobutyl chloroformate reagent system. The protection can be readily removed on demand
Armando Zarrelli, Luigi Longobardo
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New series of avenanthramides in oat seed
Bioscience, Biotechnology, and Biochemistry, 2014 Abstract Avenanthramides are characteristic constituents of oat seeds. We analyzed the methanol extract of oat seeds by HPLC and detected three compounds 1, 2, and 3 eluted at retention times similar to avenanthramides. The three compounds were purified by column chromatography and HPLC.
Atsushi, Ishihara +4 more
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Synergetic effect of doxorubicin and avenanthramide C on VDAC2/MTCH1 mitochondrial axis in breast cancer cells. [PDF]
Int J Health Sci (Qassim)Ali EMM +3 more
europepmc +2 more sources
Validation of avenanthramide and other phenolic compounds in oats and sprouted oats and their antimicrobial properties against Escherichia coli O157:H7. [PDF]
Food Sci Biotechnol, 2022 Lim S, Yun CI, Song D, Kang SS, Kim YJ.
europepmc +2 more sources
Composition and content of phenolic acids and avenanthramides in commercial oat products: are oats an important polyphenol source for consumers? [PDF]
, 2019 Oats contain a range of phenolic acids and avenanthramides which may have health benefits. Analysis of 22 commercial oat products (oat bran concentrate, oat bran, flaked oats, rolled oats and oatcakes) using HPLC-DAD detected eleven bound and thirteen ...
Alsharif, Sarah N. S. +7 more
core +2 more sources
The Biosynthetic Pathway of Major Avenanthramides in Oat [PDF]
Metabolites, 2019 Avenanthramides are a group of N-cinnamoylanthranilic acids, with health-promoting properties mainly found in oat (Avena sativa L.). However, the biosynthetic mechanism for the main three types of avenanthramides (Avn-A, Avn-B and Avn-C) is not completely understood.
Zhiyong Li +3 more
openaire +3 more sources
The gut microbiota and cardiovascular health benefits: a focus on wholegrain oats [PDF]
, 2018 Existing scientific data suggest that a high intake of wholegrain foods contributes to improved gut health and a reduced risk of cardiovascular disease.
Ahmed Nasef +183 more
core +1 more source
Nova Biotechnologica et Chimica, 2018 Oats are important cereals. Oats are a good source of protein and lipids, polyphenolics, phenolic acids, flavonoids and avenanthramides. Avenanthramides is phenolic group, which is unique in oats and have antioxidant activity, anti-inflammatory, anti ...
Kulichová Katarína +4 more
doaj +1 more source
Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner [PDF]
, 2016 Oats contain unique bioactive compounds known as avenanthramides (AVAs) with antioxidant properties. AVAs might enhance the endogenous antioxidant cellular response by activation of the transcription factor Nrf2.
Bellido, Teresita +4 more
core +2 more sources