Results 91 to 100 of about 13,248 (184)

Electron density of avibactam bound to the active site of KPC-2.

, 2015
A, |Fo|-|Fc| electron density difference density is depicted for the ligand (contoured at 3.25σ). The covalently-bound avibactam is shown in blue stick model. Prior to the map calculation, the model with the avibactam ligand removed has been subjected to
Nikhil P. Krishnan (792291), Focco van den Akker (158508), Nhu Q. Nguyen (792292), Robert A. Bonomo (188763), Krisztina M. Papp-Wallace (792293)   +4 more
core   +1 more source

Aztreonam Combinations with Avibactam, Relebactam, and Vaborbactam as Treatment for New Delhi Metallo-β-Lactamase-Producing Enterobacterales Infections—In Vitro Susceptibility Testing

Pharmaceuticals
Antimicrobial resistance is a major global health issue. Metallo-β-lactamases (MBL), in particular, are problematic because they can inactivate all classes of β-lactams except aztreonam.
Małgorzata Brauncajs, Filip Bielec, Marlena Malinowska, Dorota Pastuszak-Lewandoska   +3 more
doaj   +1 more source

Molecular Mechanism of Avibactam-Mediated β‑Lactamase Inhibition

, 2015
Emerging β-lactamase-mediated resistance is threatening the clinical utility of the single most prominent class of antibacterial agents used in medicine, the β-lactams.
Dustin T. King (534327), Natalie C. J. Strynadka (407282), Andrew M. King (1483891), Gerard D. Wright (172224), Sarah M. Lal (1621387)   +4 more
core   +1 more source

Therapeutic drug monitoring of ceftazidime/avibactam: why one leg is not enough to run

Background: Therapeutic drug monitoring (TDM) is becoming an increasingly recommended approach for assessing optimal pharmacokinetic/pharmacodynamic (PK/PD) target attainment of ceftazidime/avibactam.
Gatti, Milo, Viale, Pierluigi, Pea, Federico   +2 more
core   +1 more source

Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

Microbiology Spectrum
Cefiderocol, a siderophore-cephalosporine conjugate antibiotic, shows promise as a therapeutic option for carbapenem-resistant (CR) Acinetobacter infections. While resistance has already been reported in A. baumannii, combination therapies with avibactam
Olivia Wong, Vyanka Mezcord, Christina Lopez, German Matias Traglia, Fernando Pasteran, Marisel R. Tuttobene, Alejandra Corso, Marcelo E. Tolmasky, Robert A. Bonomo, María Soledad Ramirez   +9 more
doaj   +1 more source

Emergence of KPC-8-producing K. pneumoniae infection without prior exposure to ceftazidime/avibactam: the threat of de novo infections by ceftazidime/avibactam-resistant KPC variants

De novo infections caused by ceftazidime/avibactam-resistant KPC variants are rarely reported. We characterize the evolution of a KPC-8-producing Klebsiella pneumoniae strain involved in a primary infection without previous ceftazidime/avibactam ...
Mateo-Vargas, María Alejandra, Rodríguez-Pallares, Salud, Galán-Sánchez, Fátima, Arca-Suárez, Jorge, López Cerero, Lorena, Rodríguez-Iglesias, Manuel   +5 more
core   +1 more source

Molecular Characterization of Carbapenem-Nonsusceptible Enterobacterial Isolates Collected during a Prospective Interregional Survey in France and Susceptibility to the Novel Ceftazidime-Avibactam and Aztreonam-Avibactam Combinations

, 2016
International audienceAn interregional surveillance program was conducted in the northwestern part of France to determine the prevalence of carbapenem-nonsusceptible Enterobacteriaceae (CNSE) isolates and their susceptibility to ceftazidime-avibactam and
Plassart, Claire, Dupont, Herve, Mammeri, Hedi, Gaillot, Olivier, Cattoir, Vincent, Lecuru, Marion, Derdouri, Sarah, Emond, Jean-Philippe, Goetgheluck, Anne-Sophie, Gaillard, Nicolas, Courtilles, Marion Girard, De, Lemaire, Baptiste   +11 more
core   +1 more source

Pharmacokinetics and Dialytic Clearance of Ceftazidime-Avibactam in a Critically Ill Patient on Continuous Venovenous Hemofiltration

, 2017
Ceftazidime-avibactam administered at 1.25 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa bacteremia in a critically ill patient on continuous venovenous hemofiltration (CVVH).
Eric Wenzler, Larry H. Danziger, Scott Benken, Susan C. Bleasdale, Kristen L. Bunnell, Keith A. Rodvold   +5 more
core   +1 more source

Activity of ceftazidime-avibactam combinations against carbapenem-resistant Klebsiella pneumoniae assessed by checkerboard method

: The aim of this study is to detect the carbapenemase type and to determine the in vitro effects of ceftazidime/avibactam-colistin, ceftazidime/avibactam-meropenem and ceftazidime/avibactam-tigecycline combinations against Carbapenem-Resistant ...
Ayten Nur Uzun, Uzun, Ayten Nur, Hilal Tanriverdi, Tanriverdi, Hilal, GENÇ, SERPİL, Serpil Genç   +5 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source