Results 101 to 110 of about 13,248 (184)

Avibactam–Cyclodextrin Inclusion Complexes: Computational and Thermodynamic Insights for Drug Delivery, Detection, and Environmental Scavenging

Molecules
The escalating crisis of multidrug resistance, together with the persistence of antibiotic residues in clinical and environmental matrices, demands integrated strategies that couple sensitive detection, efficient decontamination, and controlled delivery.
Jackson J. Alcázar, Paola R. Campodónico, René López   +2 more
doaj   +1 more source

In-vitro selection of ceftazidime-avibactam resistance in Enterobacteriaceae with KPC-3 carbapenemase

, 2015
Ceftazidime-avibactam is active against most Enterobacteriaceae isolates with KPC carbapenemases. We investigated whether this activity could be compromised by mutation.
Warner, Marina, Mustafa, Nazim, Livermore, David, Nichols, Wright W., Jamrozy, Dorota, Woodford, Neil, Mushtaq, Shazad   +6 more
core   +1 more source

Ceftaroline pharmacokinetics/pharmacodynamics in the hollow-fibre model of Mycobacterium abscessus lung disease

IJTLD Open
BACKGROUND: Guideline-based therapy (GBT) of Mycobacterium abscessus (MAB) lung disease (LD) achieves a sputum culture conversion rate in ∼35% of patients. The β-lactam antibiotics, imipenem and cefoxitin, are the cornerstone of GBT.
B.E. Ferro, S. Srivastava, T. Gumbo
doaj   +1 more source

Enhancement and Comparison of (Ceftazidime-)Avibactam Plus Aztreonam Susceptibility Tests for Stenotrophomonas maltophilia in Clinical Diagnostics [PDF]

Stenotrophomonas maltophilia is naturally resistant to many antimicrobials. We evaluated the in vitro activity and reproducibility of two different super-position methods of aztreonam in combination with ceftazidime-avibactam for S.
Huis in ’t Veld, Robert A.G., Kampinga, Greetje A., Bathoorn, Erik, Hughes, Laura A., Vlaspolder, Gro L.   +4 more
core   +1 more source

**In vitro** antibacterial activity of the ceftazidime-avibactam (NXL104) combination against **Pseudomonas aeruginosa** clinical isolates

, 2012
: The beta-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa ...
Goossens, Herman, Coleman, Kenneth, Girard, Anne-Marie, Claudon, Monique, Black, Michael T., Levasseur, Premavathy, Miossec, Christine   +6 more
core  

Prevalence and mortality of ceftazidime/avibactam-resistant KPC-producing Klebsiella pneumoniae bloodstream infections (2018–2022) [PDF]

Funding Information: Open access funding provided by Università degli Studi di Torino within the CRUI-CARE Agreement. This research was supported by EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project ...
Bianco, Gabriele, Costa, Cristina, Bastos, Paulo, Almeida, André, Cavallo, Rossana, Boattini, Matteo, Comini, Sara, De Rosa, Francesco Giuseppe, Corcione, Silvia   +8 more
core   +1 more source

Investigating Gram-negative bacilli isolates’ sensitivity to ceftazidime/avibactam

Background: Multidrug resistant (MDR) Gram negative organisms are becoming increasingly common. Carbapenem resistant Enterobacterales (CRE) pose a major threat and necessitate the development of new antibiotics.
Mithilesh Kumar Jha, Mukesh Kumar, Sunali, Maneesh Kumar, Nishant Ranjan   +4 more
core   +1 more source

Avaliação do sinergismo entre ceftazidima/avibactam-aztreonam e aztreonam/avibactam frente a Klebsiella pneumoniae utilizando espectrometria de massa maldi-tof

A disseminação de Enterobacterales produtores de carbapenemases, especialmente do tipo NDM, representa um importante desafio terapêutico, devido à elevada resistência aos antimicrobianos β-lactâmicos e à escassez de opções terapêuticas eficazes ...
Santos, Jéssica Nesello dos
core  

ESBL termelő baktériumok ceftazidim/avibactam érzékenységének in vitro vizsgálata

, 2015
ESBL termelő törzsek érzékenységének ceftazidim/avibactam kombináció és különböző carbapenemek (imipenem, meropenem, doripenem) in vitro vizsgálata. A célkitűzésem az volt, hogy az in vitro eredmények alapján a ceftazidim/avibactam kombináció megfelelő ...
Incze, Boglárka
core  

Antimicrobial activity of aztreonam/avibactam and molecular characterization of Enterobacterales not susceptible to ceftazidime/avibactam and/or meropenem/vaborbactam from US medical centres (2016-2024). [PDF]

J Antimicrob Chemother
Sader HS, Papp-Wallace KM, Kimbrough JH, Debabov D, Mendes RE, Castanheira M.   +5 more
europepmc   +1 more source