Microbiology SpectrumCefiderocol, a siderophore-cephalosporine conjugate antibiotic, shows promise as a therapeutic option for carbapenem-resistant (CR) Acinetobacter infections. While resistance has already been reported in A. baumannii, combination therapies with avibactam
Olivia Wong +9 more
doaj +1 more source
mBio, 2017 The emergence of Klebsiella pneumoniae carbapenemases (KPCs), β-lactamases that inactivate “last-line” antibiotics such as imipenem, represents a major challenge to contemporary antibiotic therapies.
Melissa D. Barnes +11 more
doaj +1 more source
Ceftazidime/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae [PDF]
, 2017 The spread of carbapenemase-producing Klebsiella pneumoniae is a major public health concern since such isolates are basically resistant to most available antibiotics, including β-lactams, fluoroquinolones and aminoglycosides.1 Infections due to ...
Dubois, Véronique +3 more
core +1 more source
Shifting Gears: The Future of Polymyxin Antibiotics
Antibiotics, 2019 The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, 25 to 26 April 2018.
Justin R. Lenhard +3 more
doaj +1 more source
Effective antibiotic conservation by emergency antimicrobial stewardship during a drug shortage [PDF]
, 2016 We present the first description of an antimicrobial stewardship program (ASP) used to successfully manage a multi-antimicrobial drug shortage. Without resorting to formulary restriction, meropenem utilization decreased by 69% and piperacillin-tazobactam
Casabar, Ed +8 more
core +2 more sources
Infections Caused by Carbapenem-Resistant Enterobacteriaceae: An Update on Therapeutic Options
Frontiers in Microbiology, 2019 Carbapenems are considered as last-resort antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in clinical practice, the emergence of carbapenem-resistant pathogens now ...
Chau-Chyun Sheu +10 more
doaj +1 more source
Advances in antibiotic therapy in the critically ill [PDF]
, 2016 Infections occur frequently in critically ill patients and their management can be challenging for various reasons, including delayed diagnosis, difficulties identifying causative microorganisms, and the high prevalence of antibiotic-resistant strains ...
Antonelli, Massimo +13 more
core +2 more sources
Activity of ceftolozane/tazobactam against surveillance and ‘problem’ Enterobacteriaceae, Pseudomonas aeruginosa and non-fermenters from the British Isles [PDF]
, 2017 Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against ‘problem’ isolates sent to the UK national reference laboratory from July 2015, when ...
Aiysha Chaudhry +43 more
core +1 more source
Treatment Options for urinary tract infections caused by extended-spectrum B-lactamase-producing Escherichia coli and Klebsiella pneumoniae [PDF]
, 2015 Increased utilization of antibiotics has contributed to greater resistance among pathogenic bacteria. The prevalence of such organisms has created challenges for practitioners treating bacterial infections.
Resman-Targoff, Beth +1 more
core
MoleculesThe escalating crisis of multidrug resistance, together with the persistence of antibiotic residues in clinical and environmental matrices, demands integrated strategies that couple sensitive detection, efficient decontamination, and controlled delivery.
Jackson J. Alcázar +2 more
doaj +1 more source