Results 91 to 100 of about 90,586 (267)

In Vivo comparative evaluation of early- and late-stage ACLT-hMnX rat models: a case study of avidin as a cartilage-penetrating nanocarrier for disease-modifying osteoarthritis drugs

Frontiers in Pharmacology
BackgroundOsteoarthritis is the most prevalent joint disease worldwide, affecting over 600 million people. Cartilage-penetrating systems, such as avidin, are emerging as a therapeutic approach for the delivery of disease-modifying osteoarthritis drugs ...
Luca Morici, Luca Morici, Eric Allémann, Eric Allémann, Olivier Jordan, Olivier Jordan   +5 more
doaj   +1 more source

Fluorometric assay for quantitation of biotin covalently attached to proteins and nucleic acids

BioTechniques, 2007
As a component of the (strept)avidin affinity system, biotin is often covalently linked to proteins or nucleic acids. We describe here a microplate-based high-throughput fluorometric assay for biotin linked to either proteins or nucleic acids based on ...
Robert H. Batchelor, Adam Sarkez, W. Gregory Cox, Iain Johnson   +3 more
doaj   +1 more source

Myeloid Focal Adhesion Kinase Promotes Macrophage Accumulation but Does Not Alter Tumor Progression in Hepatocellular Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) develops within an immunologically complex tumor microenvironment that is heavily shaped by infiltrating myeloid cells. Immune‐based treatment strategies such as atezolizumab plus bevacizumab have shown promising therapeutic benefits, but patients do not experience durable responses.
Eugene Ham, Kyle Boedeker, Claudia Rose Keating, Ruisong Ye, Frankie Montalbano, Sophia Mankaruse, Xianzhong Ding, Jonathan P. Rennhack, Wei Qiu   +8 more
wiley   +1 more source

Chicken genome analysis reveals novel genes encoding biotin-binding proteins related to avidin family

BMC Genomics, 2005
Background A chicken egg contains several biotin-binding proteins (BBPs), whose complete DNA and amino acid sequences are not known. In order to identify and characterise these genes and proteins we studied chicken cDNAs and genes available in the NCBI ...
Nordlund Henri R, Grapputo Alessandro, Hytönen Vesa P, Niskanen Einari A, Kulomaa Markku S, Laitinen Olli H   +5 more
doaj   +1 more source

Harnessing Aggregation‐Induced Emission for Advanced Disease Diagnosis: Mechanisms, Strategies and Future Perspectives

Medicine Bulletin, EarlyView.
The figure was created in BioRender.com. ABSTRACT Accurate and early diagnosis remains a key challenge in modern disease management. Conventional diagnostic methods often suffer from limitations in sensitivity, spatial resolution, and practical usability.
Zizhuo Du, Li Song, Xingrui Chen, Jun Jing, Yingchen Wang, Yue Jiang, Jiahui Gao, Dan Li, Feiran Xie, Peihong Xiao, Ben Zhong Tang   +10 more
wiley   +1 more source

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

European Cells & Materials, 2017
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics.
AG Bajpayee, RE De la Vega, M Scheu, NH Varady, IA Yannatos, LA Brown, Y Krishnan, TJ Fitzsimons, P Bhattacharya, EH Frank, AJ Grodzinsky, RM Porter   +11 more
doaj   +1 more source

Determination of the quantity of acetyl CoA carboxylase by [14C]methyl avidin binding

Journal of Lipid Research, 1987
Conditions are described under which monomeric [14C]methyl avidin binds to SDS-denatured biotin enzymes and remains bound through polyacrylamide gel electrophoresis. The location of radioactive proteins on the dried gel was determined by fluorography and
C R Roman-Lopez, J Goodson, J B Allred
doaj   +1 more source

The molecular structure of avidin family of proteins.

, 2014
The structure, here represented with biotin-bound avidin (PDB identifier 2AVI), is a homotetramer composed of units of ∼128 residues. Subunits are numbered according to [4]. Each subunit binds one biotin molecule, shown in stick representation. ChiAVD is
Perttu Permi (150487), Sampo Kukkurainen (219280), Niklas Kähkönen (587997), Juha A. E. Määttä (166929), Vesa P. Hytönen (7531), Markku S. Kulomaa (7541), Tero Pihlajamaa (587998), Helena Tossavainen (198209)   +7 more
core   +1 more source

Noninvasive or minimally invasive neuromodulation in animal models of acute ischemic stroke: A systematic review and meta‐analysis

Neuroprotection, EarlyView.
This systematic review and meta‐analysis assessed the cytoprotective effects of neuromodulation in preclinical models of ischemic stroke. Pooled analyses showed that neuromodulation significantly reduced infarct volume and improved neurological outcomes.
Igor Caitano Salles, Mateus Paquesse Pellegrino, Jessica Borges Kroth, Clara Lucato dos Santos, Luca Schiliro Tristao, Jullyanna Sabrysna Morais Shinosaki, Wanderley Marques Bernardo, Adriana Bastos Conforto   +7 more
wiley   +1 more source

Inflammation and Cancer: Extra- and Intracellular Determinants of Tumor-Associated Macrophages as Tumor Promoters

Mediators of Inflammation, 2017
One of the hallmarks of cancer-related inflammation is the recruitment of monocyte-macrophage lineage cells to the tumor microenvironment. These tumor infiltrating myeloid cells are educated by the tumor milieu, rich in cancer cells and stroma components,
Gabor J. Szebeni, Csaba Vizler, Klara Kitajka, Laszlo G. Puskas   +3 more
doaj   +1 more source