Results 191 to 200 of about 104,244 (349)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

cGMP-Dependent Protein Kinase Encoded byforagingRegulates Motor Axon Guidance inDrosophilaby Suppressing Lola Function

, 2016
Qionglin Peng, Yijin Wang, Meixia Li, Deliang Yuan, Mengbo Xu, Changqing Li, Zhefeng Gong, Renjie Jiao, Li Liu   +8 more
openalex   +2 more sources

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

Zebrafish bashful/laminin‐α1 mutants exhibit multiple axon guidance defects [PDF]

, 2005
Jeremiah D. Paulus, Mary C. Halloran
openalex   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Segment-specific axon guidance by Wnt/Fz signaling diversifies motor commands in <i>Drosophila</i> larvae. [PDF]

Elife
Takagi S, Takano S, Kubo T, Hashimoto Y, Morise S, Zeng X, Nose A.   +6 more
europepmc   +1 more source

Endoglycan plays a role in axon guidance and neuronal migration by negatively regulating cell-cell adhesion [PDF]

, 2018
Thomas Baeriswyl, Alexandre Dumoulin, Martina Schaettin, Georgia Tsapara, Vera Niederkofler, Denise Helbling, Evelyn C. Avilés, Jeannine A. Frei, Nicole H. Wilson, Matthias Gesemann, Esther T. Stoeckli   +10 more
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

NeuroD2 Modulates Hippocampal Neuronal Organization and Axon Guidance During Aging. [PDF]

In Vivo
Beker M, Bolat B, Johnson BS, Ercin N, Cakmak RK, Kaya SB, Besli N, Celik U, Beker MC.   +8 more
europepmc   +1 more source

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2. [PDF]

Elife, 2023
Kim SH, Nichols KD, Anderson EN, Liu Y, Ramesh N, Jia W, Kuerbis CJ, Scalf M, Smith LM, Pandey UB, Tibbetts RS.   +10 more
europepmc   +1 more source