Results 1 to 10 of about 50,535 (307)

A redox-dependent switch governing sensory axon degeneration and regeneration [PDF]

Scientific Reports
Zebrafish (Danio rerio) fin amputation is a widely used model for studying sensory axon degeneration and regeneration. After injury, sensory neuron terminals rapidly degenerate before regenerating.
Chia-Jung Hsieh, Lauryn M. Lee, Sandra Rieger   +2 more
doaj   +2 more sources

Interplay of axon regeneration genes and immune infiltration in spinal cord injury [PDF]

Journal of Translational Medicine
Background Spinal Cord Injury (SCI) impacts neural function and regeneration. This study aimed to identify key axon regeneration genes in SCI and their correlations with immune infiltration and SCI subtyping.
Zimin Xiang, Dingxi Fang, Danping Gao, Qi Zhang, Yuxuan Zhang, Yuping Sun, Liyan Li, Xiaoqian Zhang, Jiaxin Li, Lingzhi Ding   +9 more
doaj   +2 more sources

Aberrant information transfer interferes with functional axon regeneration [PDF]

eLife, 2018
Functional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single ...
Chen Ding, Marc Hammarlund
doaj   +2 more sources

Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2023
Axon regeneration requires actomyosin interaction, which generates contractile force and pulls the regenerating axon forward. In Caenorhabditis elegans, TLN-1/talin promotes axon regeneration through multiple down-stream events.
Yoshiki Sakai, Tatsuhiro Shimizu, Mayuka Tsunekawa, Naoki Hisamoto, Kunihiro Matsumoto   +4 more
doaj   +2 more sources

Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway [PDF]

Molecular Neurodegeneration
Background Axon regeneration within the mammalian central nervous system is extremely limited. In optic neuropathy conditions like glaucoma, the inability of retinal ganglion cell (RGC) axons to regenerate is a major impediment to functional recovery. In
Mengming Hu, Matthew B. Veldman
doaj   +2 more sources

Role of HAUS7 as a DOCK3 binding partner in facilitating axon regeneration. [PDF]

Sci Adv
Kiyota N, Shinozaki Y, Guo X, Kimura A, Kawamura K, Nishijima E, Honda S, Harada C, Nakazawa T, Namekata K, Harada T.   +10 more
europepmc   +2 more sources

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration [PDF]

Nature Communications
Motor axon regeneration following peripheral nerve injury is critical for motor recovery but therapeutic interventions enhancing this are not available.
Keunjung Heo, Tammy Szu-Yu Ho, Xiangsunze Zeng, Bruna Lenfers Turnes, Maryam Arab, Selwyn Jayakar, Kuchuan Chen, Georgios Kimourtzis, Michael C. Condro, Elisa Fazzari, Xuan Song, J. Tabitha Hees, Zhuqiu Xu, Xirui Chen, Lee B. Barrett, Laura Perrault, Roshan Pandey, Kathleen Zhang, Aparna Bhaduri, Zhigang He, Harley I. Kornblum, Jed Hubbs, Clifford J. Woolf   +22 more
doaj   +2 more sources

Interleukin-4 protects retinal ganglion cells and promotes axon regeneration [PDF]

Cell Communication and Signaling
Background The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the efficacy of interleukin-4 (IL-4), a
Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi, Guangyu Li   +5 more
doaj   +2 more sources

Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G-actin [PDF]

BMC Biology
Background Thymosin beta 4 (Tβ4) is a monomeric actin-binding protein that plays many roles in biological activities. However, some studies on the role of Tβ4 in central axon regeneration have yielded contradictory results.
Zheng Song, Along Han, Bing Hu
doaj   +2 more sources

Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration. [PDF]

Proc Natl Acad Sci U S A
Sahoo PK, Agrawal M, Hanovice N, Ward PJ, Desai M, Smith TP, SiMa H, Dulin JN, Vaughn LS, Tuszynski MH, Welshhans K, Benowitz LI, English AW, Houle JD, Twiss JL.   +14 more
europepmc   +3 more sources