Results 1 to 10 of about 769,118 (313)

Rhotekin regulates axon regeneration through the talin-Vinculin-Vinexin axis in Caenorhabditis elegans. [PDF]

PLoS Genetics, 2023
Axon regeneration requires actomyosin interaction, which generates contractile force and pulls the regenerating axon forward. In Caenorhabditis elegans, TLN-1/talin promotes axon regeneration through multiple down-stream events.
Yoshiki Sakai, Tatsuhiro Shimizu, Mayuka Tsunekawa, Naoki Hisamoto, Kunihiro Matsumoto   +4 more
doaj   +2 more sources

PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

EMBO Molecular Medicine, 2020
Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development.
Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench‐Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva   +20 more
doaj   +2 more sources

Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration

Frontiers in Neuroscience, 2018
In the nearly 10 years since PTEN was identified as a prominent intrinsic inhibitor of CNS axon regeneration, the PTEN negatively regulated PI3K-AKT-mTOR pathway has been intensively explored in diverse models of axon injury and diseases and its ...
Jie Zhang, Jie Zhang, Dakai Yang, Haoliang Huang, Yang Sun, Yang Hu   +5 more
doaj   +2 more sources

Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway [PDF]

Molecular Neurodegeneration
Background Axon regeneration within the mammalian central nervous system is extremely limited. In optic neuropathy conditions like glaucoma, the inability of retinal ganglion cell (RGC) axons to regenerate is a major impediment to functional recovery. In
Mengming Hu, Matthew B. Veldman
doaj   +2 more sources

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration [PDF]

Nature Communications
Motor axon regeneration following peripheral nerve injury is critical for motor recovery but therapeutic interventions enhancing this are not available.
Keunjung Heo, Tammy Szu-Yu Ho, Xiangsunze Zeng, Bruna Lenfers Turnes, Maryam Arab, Selwyn Jayakar, Kuchuan Chen, Georgios Kimourtzis, Michael C. Condro, Elisa Fazzari, Xuan Song, J. Tabitha Hees, Zhuqiu Xu, Xirui Chen, Lee B. Barrett, Laura Perrault, Roshan Pandey, Kathleen Zhang, Aparna Bhaduri, Zhigang He, Harley I. Kornblum, Jed Hubbs, Clifford J. Woolf   +22 more
doaj   +2 more sources

A cytidine deaminase regulates axon regeneration by modulating the functions of the Caenorhabditis elegans HGF/plasminogen family protein SVH-1. [PDF]

PLoS Genetics
The pathway for axon regeneration in Caenorhabditis elegans is activated by SVH-1, a growth factor belonging to the HGF/plasminogen family. SVH-1 is a dual-function factor that acts as an HGF-like growth factor to promote axon regeneration and as a ...
Tatsuhiro Shimizu, Takafumi Nomachi, Kunihiro Matsumoto, Naoki Hisamoto   +3 more
doaj   +2 more sources

Application of Electrical Stimulation to Enhance Axon Regeneration Following Peripheral Nerve Injury [PDF]

Bio-Protocol, 2023
Enhancing axon regeneration is a major focus of peripheral nerve injury research. Although peripheral axons possess a limited ability to regenerate, their functional recovery is very poor.
Supriya Wariyar, Patricia Ward
doaj   +2 more sources

Interleukin-4 protects retinal ganglion cells and promotes axon regeneration [PDF]

Cell Communication and Signaling
Background The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the efficacy of interleukin-4 (IL-4), a
Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi, Guangyu Li   +5 more
doaj   +2 more sources

Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G-actin [PDF]

BMC Biology
Background Thymosin beta 4 (Tβ4) is a monomeric actin-binding protein that plays many roles in biological activities. However, some studies on the role of Tβ4 in central axon regeneration have yielded contradictory results.
Zheng Song, Along Han, Bing Hu
doaj   +2 more sources

Aberrant information transfer interferes with functional axon regeneration

eLife, 2018
Functional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single ...
Chen Ding, Marc Hammarlund
doaj   +2 more sources