Results 51 to 60 of about 50,535 (307)
Advanced Functional Materials, EarlyView.A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker +16 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang +9 more
wiley +1 more source
Application of Electrical Stimulation to Enhance Axon Regeneration Following Peripheral Nerve Injury
Bio-Protocol, 2023 Enhancing axon regeneration is a major focus of peripheral nerve injury research. Although peripheral axons possess a limited ability to regenerate, their functional recovery is very poor.
Supriya Wariyar, Patricia Ward
doaj +1 more source
Intrinsic Control of Axon Regeneration [PDF]
Neuron, 2016 A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which dictates a battery of injury responses in axons and cell bodies. While some of these regulatory mechanisms are evolutionarily conserved, others are unique to the mammalian central nervous system (CNS) where spontaneous regeneration usually does not occur.
Zhigang, He, Yishi, Jin
openaire +2 more sources
Advanced Functional Materials, EarlyView.A modular biosynthetic PVA–gelatin hydrogel crosslinked via visible‐light thiol‐ene chemistry is engineered as a coating for neural electrodes. Optimizing matrix composition and mechanical properties enables the hydrogel to support astrocytic populations that guide neural differentiation and functional maturation.
Martina Genta +4 more
wiley +1 more source
Cells, 2021 Astrocytes have been associated with the failure of axon regeneration in the central nervous system (CNS), as it undergoes reactive gliosis in response to damages to the CNS and functions as a chemical and physical barrier to axon regeneration.
Hyung-Suk Yoo +2 more
doaj +1 more source
A Bioresorbable Neural Interface for On‐Demand Thermal Pain Block
Advanced Functional Materials, EarlyView.Bioresorbable, implantable neural electronics provide dynamic, on‐demand thermal modulation of peripheral nerves for safe, drug‐free pain relief. A microscale thin‐film heater and temperature sensor embedded within biodegradable encapsulants enable precise temperature control via real‐time feedback.
Jeonghwan Park +23 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Although peripheral nerves can regenerate, clinical outcomes after peripheral nerve injuries are not always satisfactory, especially in cases of severe or proximal injuries.
Takeshi Endo +4 more
doaj +1 more source
Exploring Optic Nerve Axon Regeneration [PDF]
Current Neuropharmacology, 2017 Traumatic optic nerve injury is a leading cause of irreversible blindness across the world and causes progressive visual impairment attributed to the dysfunction and death of retinal ganglion cells (RGCs). To date, neither pharmacological nor surgical interventions are sufficient to halt or reverse the progress of visual loss.
Li, Hong-Jiang +4 more
openaire +2 more sources