Results 61 to 70 of about 8,323 (256)
Facile and Green Synthesis of Saturated Cyclic Amines
Molecules, 2017 Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed +7 more
doaj +1 more source
Synthesis of a Spirocyclic Oxetane-Fused Benzimidazole [PDF]
, 2015 A new synthesis of 2-oxa-7-azaspiro[3.5]nonane is described. Spirocyclic oxetanes, including 2-oxa-6-azaspiro[3.3]heptane were converted into o-cycloalkylaminoacetanilides for oxidative cyclizations using Oxone((R)) in formic acid.
Al-Dabbagh, Fawaz +2 more
core +2 more sources
Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
ACS Medicinal Chemistry Letters, 2021 The ring strain present in azetidines can lead to undesired stability issues. Herein, we described a series of N-substituted azetidines which undergo an acid-mediated intramolecular ring-opening decomposition via nucleophilic attack of a pendant amide ...
Guoyun Bai +17 more
semanticscholar +1 more source
Oxetanes: Recent Advances in Synthesis, Reactivity and Medicinal Chemistry [PDF]
, 2016 The 4-membered oxetane ring has been increasingly exploited for its behaviors, i.e. influence on physicochemical properties as a stable motif in medicinal chemistry, and propensity to undergo ring opening reactions as a synthetic intermediate.
Bull, JA +4 more
core +1 more source
Science Translational Medicine, 2020 Bicyclic azetidines potently inhibit Cryptosporidium in vivo by targeting phenylalanyl-tRNA synthetase. An antimalarial lead gets a new target Cryptosporidiosis, a parasitic intestinal infection caused by Cryptosporidium, is particularly problematic in ...
S. Vinayak +25 more
semanticscholar +1 more source
Lithiation of 4-membered heterocycles as useful strategy for the preparation of new molecular scaffolds: addressing the regioselectivity in azetidines and thietanes [PDF]
, 2013 Four-membered heterocycles (4-MH) with one or two heteroatoms are of great importance in medicinal chemistry and synthetic organic chemistry. This kind of scaffolds show peculiar structural features, related to the ring “puckering”, and biological ...
Carroccia, Laura +7 more
core
Synthesis of oxetane- and azetidine-containing spirocycles related to the 2,5-diketopiperazine framework [PDF]
, 2015 A simple two-step sequence is used to efficiently make novel spirocyclic analogues of the diketopiperazine nucleus. Conjugate addition of chiral α-amino esters to nitroalkenes, generated from oxetan-3-one or N-Boc-azetidin-3-one, followed by nitro group ...
Beadle, Jonathan D. +4 more
core +1 more source
Recent advances in the use of chiral aldimines in asymmetric synthesis [PDF]
, 2016 Chiral N-(tert-butyl)sulfinyl aldimines easily prepared from commercially available compounds have been used as starting materials for the following processes: (i) hydrogen transfer, (ii) addition of zincates, (iii) In-promoted allylation, and (iv ...
Foubelo, Francisco, Yus, Miguel
core +2 more sources
ChemistryEurope, EarlyView.In this work, a catalytic enantioselective imidation approach is presented for the preparation of enantioenriched sulfinamidines from sulfenamides, employing a chiral dirhodium(II) tetracarboxylate catalyst. This method enables the imidation of N,N‐bisalkyl sulfenamides in yields of up to 98% and enantiomeric ratios up to 98:2, with a catalyst loading ...
Michael Andresini +7 more
wiley +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source