Results 71 to 80 of about 8,323 (256)
Molecules, 2016 Electron transfer involving nucleic acids and their derivatives is an important field in bioorganic chemistry, specifically in connection with its role in the photo-driven DNA damage and repair.
Ana B. Fraga-Timiraos +4 more
doaj +1 more source
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia +4 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee +10 more
wiley +2 more sources
DBU-promoted regioselective HBr-elimination of vicinal dibromides: effects of the adjacent oxygen and/or other heterofunctional groups [PDF]
, 2014 DBU-promoted HBr-eliminations of a variety of vicinal dibromides having an adjacent heteroatom (F, O, or N) under mild basic conditions and relevant theoretical calculations were carried out. These HBr-eliminations proceeded more or less regioselectively,
Iijima Masatoshi +6 more
core +1 more source
"Angular" Spirocyclic Azetidines: Synthesis, Characterization, and Evaluation in Drug Discovery.
Angewandte ChemieThe previously neglected "angular" spirocyclic azetidines have been synthesized, characterized, and validated in drug discovery. We have shown that these compounds could act as bioisosteres for common saturated six-membered heterocycles.
Alexander A. Kirichok +16 more
semanticscholar +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.A dioxolanyl linchpin has been used to synthesize aryl ethanolamines from readily available aryl bromide and amine starting materials using a metallaphotoredox/substitution telescoped sequence. This combinatorial approach allows for a wide synthetic scope of both heteroarenes and cyclic amines. Aryl ethanolamines are an important functional group found
Justin J. Chang +4 more
wiley +1 more source
A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols. [PDF]
, 2015 Aliphatic primary amines are a class of chemical feedstock essential to the synthesis of higher-order nitrogen-containing molecules, commonly found in biologically active compounds and pharmaceutical agents.
A McNally +52 more
core +3 more sources
Site-Selective C−H Arylation of Primary Aliphatic Amines Enabled by a Catalytic Transient Directing Group [PDF]
, 2016 Transition-metal-catalysed direct C–H bond functionalization of aliphatic amines is of great importance in organic and medicinal chemistry research. Several methods have been developed for the direct sp3 C–H functionalization of secondary and tertiary ...
Ge, Haibo, Liu, Yongbing
core +1 more source
ChemistryOpen, Volume 15, Issue 4, April 2026.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Strain‐Release Driven Spirocyclization of Azabicyclo[1.1.0]butyl Ketones [PDF]
, 2021 Due to their intrinsic rigidity, three‐dimensionality and structural novelty, spirocyclic molecules have become increasingly sought‐after moieties in drug discovery.
Aggarwal, Varinder K +2 more
core +2 more sources