Results 221 to 230 of about 132,389 (268)

Utilizing EdU to Track Leukocyte Recruitment to the Brain. [PDF]

Bio Protoc
Lipfert ZK, Arias E, Batra A, Sullivan DP.   +3 more
europepmc   +1 more source

Efficient Preparation of Homogenous Antibody Conjugates via Glycosite‐Specific Transglycosylation Enabled by Readily Available Glycosyl Donors

Angewandte Chemie, EarlyView.
A streamlined platform for glycosite‐specific antibody conjugation is enabled by LacNAc‐derived cyclic acetal donors, which can be prepared in only two steps and used directly in single‐enzyme Endo S2‐mediated transglycosylation. The platform supports the broad construction of homogeneous gsADCs and gsDACs, with donor 7 producing glycoengineered ...
Deqin Cai, Yuan Zhao, Gaoyuan Lu, Chunrong Li, Yichong Lao, Ramesh Mudududdla, Jiahao Zhang, Peijing Jia, Penghsuan Huang, Wenxin Wu, Thao‐Vy T. Nguyen, Xuhui Huang, Lingjun Li, Weiping Tang   +13 more
wiley   +1 more source

Late-stage peptide modification with salicylaldehyde tag enhances affinity for nuclear factor-kappa B essential modulator. [PDF]

RSC Chem Biol
Mason M, Peqini K, Uggeri F, Rondelli D, Sattin S, Pignataro L, Pellegrino S, Belvisi L, Scarpa E, Bucci R, Dal Corso A.   +10 more
europepmc   +1 more source

SSZ‐13‐Zeolith mit Isolierten Co2+‐Zentren als ein Effizientes und Beständiges Katalysatorsystem für die Nichtoxidative Ethandehydrierung

Angewandte Chemie, EarlyView.
Für die nichtoxidative Ethandehydrierung zu Ethen wurden Katalysatoren mit isolierten Co2+‐Spezies in den 6MR‐ (Co2+‐Z2) und 8MR‐Fenstern ([Co(OH)]+‐Z) eines SSZ‐13‐Zeolithen hergestellt. Die Co2+‐Z2‐Spezies zeigten im Vergleich zu den [Co(OH)]+‐Spezies eine unerwartet hohe Ethenbildungsgeschwindikeit.
Qiyang Zhang, Tao Zhang, Bing Liu, Elizaveta Fedorova, Dmitry E. Doronkin, Evgenii V. Kondratenko   +5 more
wiley   +1 more source

Optimized In-Solution and Gas-Phase Chemistry Enables High-Efficiency Interactome Mapping by DSBSO-Based Cross-Linking Mass Spectrometry. [PDF]

Angew Chem Int Ed Engl
Jiang PL, Zhu Y, Cai J, Wang C, Wu M, Pu K, Liu F.   +6 more
europepmc   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +1 more source

Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications. [PDF]

J Nanobiotechnology
Chen F, Bradbury MS.
europepmc   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +1 more source

Low-Cost Versatile Microfluidic Platform for Bioorthogonal Click-Mediated Nanoassembly of Hybrid Nanosystems. [PDF]

Nanomaterials (Basel)
González-Larre J, García Del Cid MA, Benita-Donadios D, Vela-Cruz Á, Jiménez-Falcao S, Baeza A.   +5 more
europepmc   +1 more source

Alkinyltriazene in photochemischen metallfreien Doyle‐Kirmse‐Umlagerungen

Angewandte Chemie, EarlyView.
Es wird eine metall‐ und additivfreie photokatalytische Doyle‐Kirmse‐Reaktion von Alkinyltriazenen beschrieben, die über Cyancarbenzwischenstufen verläuft. Diese Strategie ermöglicht den effizienten Aufbau hochsubstituierter asymmetrischer Kohlenstoffzentren mit breitem Substratspektrum und liefert synthetisch wertvolle Nitrile.
Ningning Liu, Linus Bjarne Dittmer, Melina Maag, Elena Michel, Frank Rominger, Matthias Rudolph, Andreas Dreuw, A. Stephen K. Hashmi   +7 more
wiley   +1 more source