Results 221 to 230 of about 227,350 (349)

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

open access: yesAngewandte Chemie, EarlyView.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth   +9 more
wiley   +2 more sources

Synthesis of 4-azido sialic acid for testing against Siglec-7 and in metabolic oligosaccharide engineering. [PDF]

open access: yesRSC Chem Biol
Gray TE   +8 more
europepmc   +1 more source

Indirect Anti‐Markovnikov Hydrofunctionalization of Terminal Alkenes via an Alkenyl Thianthrenium Intermediate

open access: yesAngewandte Chemie, EarlyView.
A two‐stage dication pool strategy using alkenyl thianthrenium intermediates has been developed for anti‐Markovnikov hydrofunctionalization. This method differs from previous approaches in its reaction mechanism and addresses their most significant limitation, namely, the restricted generality of the nucleophile. The approach has been extended to other
Bence Sóvári   +7 more
wiley   +2 more sources

Oxidation of Azide Ions by Hydrogen Peroxide. [PDF]

open access: bronze, 1964
Niels Hofman-Bang   +4 more
openalex   +1 more source

Optical Probes for Cellular Imaging of G‐quadruplexes: Beyond Fluorescence Intensity Probes

open access: yesAngewandte Chemie, EarlyView.
DNA and RNA can fold into tetra‐stranded helical structures known as G‐quadruplexes (G4s). There is mounting evidence suggesting that these structures have important biological roles. In this minireview we discuss advances in the design of optical probes for the detection of G4s that offer intensity‐independent readouts that address limitations of ...
Jenna Robinson   +3 more
wiley   +2 more sources

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