Results 81 to 90 of about 6,575 (208)

A Study on the Biological Activity of Optically Pure Aziridine Phosphines and Phosphine Oxides

Molecules
A series of optically pure aziridine phosphines and their corresponding phosphine oxides were synthesized through established chemical methodologies. The compounds were systematically investigated for their biological properties. Notably, all synthesized
Aleksandra Kowalczyk, Adam M. Pieczonka, Hassan Kassassir, Michał Rachwalski, Paweł Stączek   +4 more
doaj   +1 more source

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Beilstein Journal of Organic Chemistry, 2015
The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type
Hongnan Sun, Binbin Huang, Run Lin, Chao Yang, Wujiong Xia   +4 more
doaj   +1 more source

Isotopic labelling studies for a gold-catalysed skeletal rearrangement of alkynyl aziridines

Beilstein Journal of Organic Chemistry, 2011
Isotopic labelling studies were performed to probe a proposed 1,2-aryl shift in the gold-catalysed cycloisomerisation of alkynyl aziridines into 2,4-disubstituted pyrroles.
Paul W. Davies, Nicolas Martin, Neil Spencer   +2 more
doaj   +1 more source

Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols

Molecules, 2002
Two alternative and complementary one-pot procedures for the direct transformation of 2-amino alcohols to N-tosyl aziridines are presented. The unsubstituted parent compound and its less hindered homologues can be obtained in high yields by tosylation ...
Maria C. F. de Araújo, Lothar W. Bieber   +1 more
doaj   +1 more source

Unexpected ring-opening reactions of aziridines with aldehydes catalyzed by nucleophilic carbenes under aerobic conditions

, 2006
The chemoselective ring opening of N-tosyl aziridines with aldehydes catalyzed by an N-heterocyclic carbene was investigated under aerobic conditions. Unexpected carboxylates of 1,2-amino alcohols from the corresponding aldehydes, rather than the acyl ...
Yue, L, Liu, YK, Li, BJ, Liu, YK, Sichuan Univ, W China Sch Pharm, Educ Minist, Key LDrug Targeting, Chengdu 610041, Peoples R China., Wu, Y, Ding, LS, Li, R, Chen, YC   +7 more
core  

Rasta resin–triphenylphosphine oxides and their use as recyclable heterogeneous reagent precursors in halogenation reactions

Beilstein Journal of Organic Chemistry, 2014
Heterogeneous polymer-supported triphenylphosphine oxides based on the rasta resin architecture have been synthesized, and applied as reagent precursors in a wide range of halogenation reactions.
Xuanshu Xia, Patrick H. Toy
doaj   +1 more source

Triazolylmethyl Aziridines with Various Side Chain

More than hundred compounds from aziridine class shown certain biological activity. We report here the synthesis of racemic version of protected azidomethyl aziridine via easily accessible intermediates.
Trapencieris, Pēteris, Bizdēna, Ērika, Zemītis, Jānis, Kreituss, Imants, Turks, Māris   +4 more
core  

Dimerization and Isomerization Reactions of α-Lithiated Terminal Aziridines

, 2016
The scope of dimerization and isomerization reactions of α-lithiated terminal aziridines is detailed. Regio- and stereoselective deprotonation of simple terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide (LTMP) or lithium dicyclohexylamide ...
David M. Hodgson (692207), Steven M. Miles (2462320), John G. Ward (2462323), Christopher A. J. Brierley (2462317), Philip G. Humphreys (1357530)   +4 more
core   +2 more sources

Unexplored Nucleophilic Ring Opening of Aziridines

Molecules, 2010
The reactivity of dianions of carboxylic acids towards aziridines has been studied. Although, a similar reactivity to that of enolates from ketones, esters or amides has been observed, the method directly yields g-aminoacids in one step.
Ana María Costero, Salvador Gil, Margarita Parra, Pablo Rodríguez   +3 more
doaj  

Self-optimisation and model-based design of experiments for developing a C–H activation flow process

Beilstein Journal of Organic Chemistry, 2017
A recently described C(sp3)–H activation reaction to synthesise aziridines was used as a model reaction to demonstrate the methodology of developing a process model using model-based design of experiments (MBDoE) and self-optimisation approaches in flow.
Alexander Echtermeyer, Yehia Amar, Jacek Zakrzewski, Alexei Lapkin   +3 more
doaj   +1 more source