Results 61 to 70 of about 5,649 (226)

On the Planarity of Heterocyclic Bay‐Substituted Perylenediimides: Insight into the Fluorescent Photoinduced Electron Transfer Sensing Framework

European Journal of Organic Chemistry, EarlyView.
Near‐infrared fluorescent pH indicators based on perylenediimide were constructed in a modular receptor–spacer–fluorophore–spacer–receptor format with heterocyclic amino moieties at the bay positions. Counterintuitively, the dibrominated intermediate with two heavy atoms is more emissive than the heterocyclic compounds.
Luke Camenzuli, Davide Benedetto Tiz, Nicola’ Agius, Konrad Szaciłowski, David C. Magri   +4 more
wiley   +1 more source

Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides

Beilstein Journal of Organic Chemistry, 2016
A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an ...
Lena Huck, Juan F. González, Elena de la Cuesta, J. Carlos Menéndez   +3 more
doaj   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

Nature Communications, 2020
Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon, Kate A. Nicastri, Steven C. Schmid, William T. Raskopf, Ilia A. Guzei, Israel Fernández, Jennifer M. Schomaker   +6 more
doaj   +1 more source

Strong Nonradiative Recombination Induced by Pronounced Lone‐Pair Electron Expression Following Deprotonation in Aziridinium Lead Iodide Perovskites

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 4, July 2026.
The transition from linear to cyclic organic cations promotes deprotonation and activates VH(N) defects with pronounced lone‐pair electron activity, thereby inducing severe local distortions and highly efficient nonradiative recombination centers. This work unveils a direct structure–defect–performance correlation and proposes design strategies for the
Qingshan Bao, Linyu Bai, Honghe Zhao, Yanting Qin, Xian Zhao, Yanlu Li   +5 more
wiley   +1 more source

Intermolecular 3+3 Ring Expansion of Aziridines to Dehydropiperidines through the Intermediacy of Aziridinium Ylides

, 2019
Bicyclic aziridines undergo formal [3+3] ring expansion reactions when exposed to rhodium-bound vinyl carbenes to form complex dehydropiperidines in a highly stereocontrolled rearrangement.
Jennifer, Schomaker, Kate A., Nicastri, Ilia A., Guzei,, Israel, Fernández, Josephine, Eshon, William T., Raskopf, Steven C., Schmid   +6 more
core   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Unusual Selectivity of Unprotected Aziridines in Palladium-Catalyzed Allylic Amination Enables Facile Preparation of Branched Aziridines

, 2016
Functionalized branched aziridines can be prepared in high yields and with high levels of regioselectivity using unprotected aziridines as nitrogen sources in palladium-catalyzed allylic amination.
Iain D. G. Watson (1950703), Andrei K. Yudin (1470634), Sarah A. Styler (761541)   +2 more
core   +1 more source

Aziridinierung eines einzelnen Kohlenstoffatoms in Alkenen mittels Energietransferkatalyse

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
Im Gegensatz zur traditionellen Alken‐Aziridinierung über (formalen) Nitren‐Transfer berichten wir hier über eine Strategie zur intermolekularen Aziridinierung eines einzelnen Alken‐Kohlenstoffatoms bei zusätzlicher Funktionalisierung der anderen Position. Durch Energietransfer‐ (EnT‐)Katalyse werden Alkenylboronate und ‐silane in reaktive Intermediate
Fritz Paulus, Corinna Heusel, Felix H. Wessels, Bünyamin Sikora, Maik G. Niedziella, Kilian van der Beck, Constantin G. Daniliuc, Frank Glorius   +7 more
wiley   +1 more source

Ring-Opening of Aziridines by Pendant Sulfamates Allows for Regioselective and Stereospecific Preparations of Vicinal Diamines

, 2023
The ring-opening of aziridines by pendant sulfamates is a viable strategy for the rapid preparation of vicinal diamines. Our reaction is compatible with both di-substituted cis and trans aziridines; unsubstituted, N-alkyl, and N-aryl sulfamates engage ...
Someshwar, Nagamalla, Appasaheb, Nirpal, Annu Anna, Thomas, Shyam, Sathyamoorthi, Joel, Mague   +4 more
core   +1 more source