Results 51 to 60 of about 5,649 (226)

Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea

Molecules, 2017
In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were used.
Aleksandra Kowalczyk, Adam M. Pieczonka, Michał Rachwalski, Stanisław Leśniak, Paweł Stączek   +4 more
doaj   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

Chemistry – A European Journal, EarlyView.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi, Tharun K. Kotammagari, Pia Damlin, Mikko Salomäki, Mika Lastusaari, Han Li, Tuomas Lönnberg   +6 more
wiley   +1 more source

Stereoselective Synthesis of Heterosubstituted Aziridines and their Functionalization

, 2004
Lithiated (alfa-chloroalkyl)heterocycles, generated by deprotonation with LDA at -78 °C in THF, add to various enantiopure imines affording ‘one pot’ chiral heterosubstituted aziridines in a diastereoselective manner.
S. FLORIO, Renzo Luisi, Catia Granito, R. LUISI, Tullio Pilati, Saverio Florio, RONZINI, Ludovico, DE VITIS, LUISELLA, Ludovico Ronzini, V. CAPRIATI, T. PILATI, Luigino Troisi, Vito Capriati, TROISI, Luigino, Luisella De Vitis, GRANITO, Catia   +15 more
core   +2 more sources

Nitrooxylation in Organic Synthesis: From Classical Nitrate Ester Formation to Modern Catalytic Strategies

Chemistry – A European Journal, EarlyView.
Nitrooxylation—the installation of nitrate esters (–ONO2) has evolved from classical mixed‐acid protocols to catalytic and mechano‐, flow‐, photo‐, and electrochemical strategies. This review delineates ionic and radical manifolds for C–ONO2 bond formation, emphasizing mechanistic control, selected substrate scope, and selectivity.
Jayanta Dey, Dmitry Katayev
wiley   +1 more source

Synthesis and ring openings of cinnamate-derived N-unfunctionalised aziridines

Beilstein Journal of Organic Chemistry, 2012
tert-Butyl cinnamates are aziridinated with high trans-selectivity by an N–N ylide generated in situ from N-methylmorpholine and O-diphenylphosphinyl hydroxylamine.
Alan Armstrong, Alexandra Ferguson
doaj   +1 more source

Preparation and ring-opening reactions of N-Diphenylphosphinyl aziridines

, 1998
Monochiral N-Diphenyphosphinyl aziridines(n-Dpp aziridines)may efficiently be prepared from monochiral 2-aminoalcohols. Such aziridines undergo ring-opening reaction with a variety of nucleophiles in good yield.
Sweeney, Joseph B., Osborn, Helen M.I., Cantrill, Alex A.   +2 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Alcohol‐Directed Carboamination of Conjugated Enynes

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
The first general three‐component intermolecular Pd‐catalyzed carboamination of conjugated enynes enables the coupling of anilines and aryl triflates to produce functionalized allenic amines, utilizing a native alcohol directing group to control regioselectivity.
Helena Solé‐Àvila, Duncan K. Brownsey, Hugo Senelle, Jerome Waser   +3 more
wiley   +2 more sources