Results 41 to 50 of about 5,649 (226)

Enantioselective synthesis of aziridines using asymmetric transfer hydrogenation as a precursor for chiral derivatives used as bonding agent for rocket solid propellants

Química Nova, 2002
A rapid, expedient and enantioselective method for the synthesis of beta-hydroxy amines and monosubstituted aziridines in up to 99% e.e., via asymmetric transfer hydrogenation of a-amino ketones and cyclisation through treatment with tosyl chloride and ...
Aparecida M. Kawamoto, Martin Wills
doaj   +1 more source

Substituted Aziridines by Lithiation−Electrophile Trapping of Terminal Aziridines

, 2016
Regio- and stereoselective deprotonation of N-Bus (Bus = tert-butylsulfonyl)-protected terminal aziridines with lithium 2,2,6,6-tetramethylpiperidide generates a nonstabilized (H-substituted) aziridinyl anion that undergoes in situ or external ...
David M. Hodgson (692207), John G. Ward (2462323), Philip G. Humphreys (1357530)   +2 more
core   +1 more source

Recent Advances in Transition Metal-Catalyzed Ring-Opening Reaction of Aziridine

Compounds
The smallest strained, saturated N-heterocycles, such as aziridine, can be a valuable building block in synthetic organic chemistry. Ring-opening reactions with various nucleophiles could be the most important strategy to synthesize various value-added ...
Partha Sarathi Bera, Yafia Kousin Mirza, Tarunika Sachdeva, Milan Bera   +3 more
doaj   +1 more source

Efficient synthesis of ethyl 2-(oxazolin-2-yl)alkanoates via ethoxycarbonylketene-induced electrophilic ring expansion of aziridines

Beilstein Journal of Organic Chemistry, 2022
Alkyl 2-diazo-3-oxoalkanoates generate alkoxycarbonylketenes, which undergo an electrophilic ring expansion with aziridines to afford alkyl 2-(oxazolin-2-yl)alkanoates in good to excellent yields under microwave heating.
Yelong Lei, Jiaxi Xu
doaj   +1 more source

Deprotection of Sulfonyl Aziridines

, 2016
The deprotection of the chiral N-sulfonyl aziridines 1−3 has been studied under different desulfonylation conditions. Two methods for the efficient deprotection of 2-benzyl-, 2-phenyl-, and 2-carboxyl-N-sulfonylaziridines were found.
Diego A. Alonso (2145664), Pher G. Andersson (1478632)   +1 more
core   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Beilstein Journal of Organic Chemistry, 2011
A variety of 2-amino-3-arylpropan-1-ols, anti-2-amino-3-aryl-3-methoxypropan-1-ols and anti-2-amino-1-arylpropan-1,3-diols were prepared selectively through elaboration of trans-4-aryl-3-chloro-β-lactams.
Matthias D’hooghe, Stéphanie Vandekerckhove, Karen Mollet, Karel Vervisch, Stijn Dekeukeleire, Liesbeth Lehoucq, Carmen Lategan, Peter J. Smith, Kelly Chibale, Norbert De Kimpe   +9 more
doaj   +1 more source

Formation of Scalemic Aziridines via the Nucleophilic Opening of Aziridines

, 2016
Formation of Scalemic Aziridines via the Nucleophilic Opening of ...
Punit P. Seth (628027), Stephen C. Bergmeier (2042587)   +1 more
core   +1 more source

Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

Molecules, 2020
This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and sulfur nucleophiles to the C–N double bond of 2H-azirine derivatives. Determined by the nature
Victor Carramiñana, Ana M. Ochoa de Retana, Francisco Palacios, Jesús M. de los Santos   +3 more
doaj   +1 more source

Ambident Reactivity in the Phenyl + NO Radical Recombination

Chemistry – A European Journal, EarlyView.
ABSTRACT The recombination reaction of nitric oxide (NO) with radicals via its oxygen atom, rather than the more common nitrogen site, offers an intriguing pathway to the formation of oxynitrenes. The photochemical isomerization of nitroso compounds into their corresponding oxynitrenes may involve such a step.
Virinder Bhagat, Adrián Portela‐González, André K. Eckhardt, J. Philipp Wagner   +3 more
wiley   +1 more source