Results 41 to 50 of about 2,054 (167)

1,2‐Diazetidines − Structure, Synthesis, and Functionalization

European Journal of Organic Chemistry, EarlyView.
1,2‐Diazetidines are saturated four‐membered heterocycles featuring two adjacent nitrogen atoms. Despite recent advances in their synthesis and promising potential in medicinal chemistry, the chemistry of these cyclic hydrazines remains underexplored.
Stefan Roesner
wiley   +1 more source

Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea

Molecules, 2017
In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were used.
Aleksandra Kowalczyk, Adam M. Pieczonka, Michał Rachwalski, Stanisław Leśniak, Paweł Stączek   +4 more
doaj   +1 more source

Advances in the Different Synthetic Routes of Fluorinated Hydrazines

The Chemical Record, EarlyView.
This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Synthesis and ring openings of cinnamate-derived N-unfunctionalised aziridines

Beilstein Journal of Organic Chemistry, 2012
tert-Butyl cinnamates are aziridinated with high trans-selectivity by an N–N ylide generated in situ from N-methylmorpholine and O-diphenylphosphinyl hydroxylamine.
Alan Armstrong, Alexandra Ferguson
doaj   +1 more source

Dimerization of Lithiated Terminal Aziridines

Synfacts, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Hodgson, David M., Miles, Steven M.
openaire   +3 more sources

Synthesis of a Carbon‐Linked Acyldepsipeptide Derivative

European Journal of Organic Chemistry, Volume 29, Issue 15, 22 April 2026.
The synthesis of a methylene‐linked acyldepsipeptide (ADEP) is reported. Success relied upon an improve method to generate a versatile vinyl glycine methyl ester synthon and a rationally optimized Grubb’s metathesis. NMR and in silico studies revealed an unusual trans–trans proline orientation for this new unnatural ADEP analog, advancing the ...
Katelyn G. Stevens-Davis, Xiaozheng Dou, Bo Hu, Yangxiong Li, Jiayuan Miao, Yu-Shan Lin, Adam S. Duerfeldt   +6 more
wiley   +1 more source

Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides

Beilstein Journal of Organic Chemistry, 2016
A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an ...
Lena Huck, Juan F. González, Elena de la Cuesta, J. Carlos Menéndez   +3 more
doaj   +1 more source

Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

Nature Communications, 2020
Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon, Kate A. Nicastri, Steven C. Schmid, William T. Raskopf, Ilia A. Guzei, Israel Fernández, Jennifer M. Schomaker   +6 more
doaj   +1 more source

Terminal Aziridines by α-Deprotonation/Electrophile Trapping of N-Protected Aziridine

Organic Letters, 2008
N-tert-Butylsulfonyl and N-tert-butylsulfinyl aziridine undergo alpha-lithiation/electrophile trapping providing a new entry to terminal aziridines. With N-tert-butylsulfinyl aziridine complete asymmetric induction is observed alpha to nitrogen.
Hodgson, D, Hughes, S, Thompson, A, Heightman, T   +3 more
openaire   +2 more sources