2H-Azirines as electrophiles [PDF]
, 2011 2H-Azirines have shown an unusual potential to synthesise aziridines and other types of compounds. Many functionalized aziridines can be produced by addition of O-, S-,N-, C-nucleophiles and hydride to 2H-azirines. This review is designed to give an overview of the reactivity of 2H-azirines as electrophiles along the years and their usefulness in the ...
Alves, M. José, Costa, Flora Teixeira e
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Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis [PDF]
Nature CommunicationsFor decades, progress in chiral transition metal catalysis has been closely linked to the design of tailor-made chiral ligands. Recently, an alternative to this conventional paradigm has emerged in which the overall chirality of the catalysts arises ...
Su-Yang Yao +7 more
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Diastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines [PDF]
MoleculesWe disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi three-component reaction of phosphorylated 2H-azirines, carboxylic acids and isocyanides.
Julene Allende +4 more
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A Novel Class of "Super-Strained" Spiro Heterocycles: Gateway to 1-Azaspiro[3.3]heptane Derivatives, and Biological Validation. [PDF]
Angew Chem Int Ed EnglA new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Natho P +9 more
europepmc +3 more sources
Substituent Effects Govern the Efficiency of Isoxazole Photoisomerization to Carbonyl‑2H‑Azirines [PDF]
ACS Organic & Inorganic AuKyra E. Jackson +3 more
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Selective Synthesis of 3‑(1H‑Tetrazol-5-yl)-indoles from 2H‑Azirines and Arynes [PDF]
ACS OmegaCarla Grosso +6 more
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Strain Release of 1-Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs. [PDF]
ChemistryOver the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Gelato Y, Natho P, Colella M, Luisi R.
europepmc +2 more sources
Lewis Acid Mediated Alkylation and Diels-Alder Reactions of 2H-Azirines [Elektronisk resurs]
, 2002 This thesis describes the use of 2H-azirines as reactivesubstrates in Lewis acid catalysed nucleophilic additions andin the Diels-Alder reaction.A number of carbon nucleophiles have been added to aseries of 2H-azirines in the presence and absence ofBF3 ...
Risberg, Erik,
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2H-Azirines as dipolarophiles [PDF]
Tetrahedron Letters, 2003 AbstractFor Abstract see ChemInform Abstract in Full Text.
Melo, Teresa M. V. D. Pinho e +3 more
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Late-Stage Functionalization of Peptides on the Solid Phase. [PDF]
Angew Chem Int Ed EnglPeptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Werner M, Pham TL, Thomas F.
europepmc +2 more sources