Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity [PDF]
MoleculesEasy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko +3 more
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Isomerization of 5-(2H-Azirin-2-yl)oxazoles: An Atom-Economic Approach to 4H-Pyrrolo[2,3-d]oxazoles [PDF]
Molecules, 2021 An atom economical method for the preparation of variously substituted 4H-pyrrolo[2,3-d]oxazoles was developed on the basis of thermal isomerization of 5-(2H-azirin-2-yl)oxazoles.
Timur O. Zanakhov +4 more
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Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination [PDF]
Beilstein Journal of Organic Chemistry, 2018 The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO ...
Jiyun Sun +5 more
doaj +3 more sources
Light-induced synthesis of 2H-azirines and its applications in organic chemistry
Journal of Saudi Chemical Society2H-azirines have represented versatile building motifs in the domain of organic chemistry owing to their excellent reaction activity induced by the high strain of the three-membered ring species.
Shibo Lin, Lifeng Zhao
exaly +3 more sources
2H-Azirines as electrophiles [PDF]
, 2011 2H-Azirines have shown an unusual potential to synthesise aziridines and other types of compounds. Many functionalized aziridines can be produced by addition of O-, S-,N-, C-nucleophiles and hydride to 2H-azirines.
Alves, M. José, Costa, Flora Teixeira e
core +2 more sources
Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis [PDF]
Nature CommunicationsFor decades, progress in chiral transition metal catalysis has been closely linked to the design of tailor-made chiral ligands. Recently, an alternative to this conventional paradigm has emerged in which the overall chirality of the catalysts arises ...
Su-Yang Yao +7 more
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Diastereoselective ZnCl2-Mediated Joullié–Ugi Three-Component Reaction for the Preparation of Phosphorylated N-Acylaziridines from 2H-Azirines [PDF]
MoleculesWe disclose a direct approach to the diastereoselective synthesis of phosphorus substituted N-acylaziridines based on a one-pot ZnCl2-catalyzed Joullié–Ugi three-component reaction of phosphorylated 2H-azirines, carboxylic acids and isocyanides.
Julene Allende +4 more
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Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells [PDF]
Molecules, 2020 This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and sulfur nucleophiles to the C–N double bond of 2H-azirine derivatives. Determined by the nature
Victor Carramiñana +3 more
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Synthesis and Application of Bioactive N-Functionalized Aziridines. [PDF]
Angew Chem Int Ed EnglThis review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Tan H +4 more
europepmc +3 more sources
Substituent Effects Govern the Efficiency of Isoxazole Photoisomerization to Carbonyl‑2H‑Azirines [PDF]
ACS Organic & Inorganic AuKyra E. Jackson +3 more
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