Results 41 to 50 of about 1,101 (192)

Synthesis of Stable 1H-Azirines Reinvestigated: A Structural Corrigendum

, 2012
The isoquinoline-catalyzed synthesis of pretended 1H-azirines from phenacyl bromides and N,N\'-dialkylcarbodiimides was repeated. The products do not possess the structure of antiaromatic 1H-azirines, but simple N-acyl-N,N\'-dialkylureas were formed ...
Peisker, Heiko, Banert, Klaus, Hagedorn, Manfred   +2 more
core   +1 more source

Synthesis of Polyhydroxylated 2H-Azirines and 2-Halo-2H-azirines from 3-Azido-2,3-dideoxyhexopyranoses by Alkoxyl Radical Fragmentation

, 2016
The reaction of 3-azido-2,3-dideoxypyranose and 3-azido-2,3-dideoxy-2-halohexopyranose compounds with (diacetoxyiodo)benzene and iodine generated 2-azido-1,2-dideoxy-1-iodoalditols and 2-azido-1,2-dideoxy-1-halo-1-iodoalditols, respectively. These β-iodo
María S. Rodríguez (2001400), Ernesto Suárez (1325961), Alan R. Kennedy (1266753), Carmen R. Alonso-Cruz (2435974)   +3 more
core   +3 more sources

Neuere Methoden zur Ringerweiterung organischer Verbindungen

CHIMIA, 1980
The actual interest in the construction of cyclic compounds via ring expansion reactions is demonstrated in the first chapter by means of typical examples.
Heinz Heimgartner
doaj   +1 more source

The Neber approach to 2-(Tetrazol-5-yl)-2H-Azirines

, 2014
The synthesis of 2-(tetrazol-5-yl)-2H azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2Hazirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3.
Gimeno, Lourdes, Melo, Teresa M. V. D. Pinho e, Cardoso, Ana Lúcia, Lemos, A., Palacios, Francisco   +4 more
core   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

Chemistry – A European Journal, EarlyView.
Three 2‐phosphinophenylaluminum dichloride complexes were synthesized and characterized as novel intramolecular FLPs. These FLP systems exhibit high Lewis acidity and effectively activate challenging substrates including aliphatic ketones, imines, and esters. DFT analysis revealed that strain release and Al–P dynamics govern their reactivity. Abstract (
Yoshihiro Nishimoto, Hirotaka Okamoto, Makoto Yasuda   +2 more
wiley   +1 more source

Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

Beilstein Journal of Organic Chemistry, 2018
The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO ...
Jiyun Sun, Xiaohua Zhen, Huaibin Ge, Guangtao Zhang, Xuechan An, Yunfei Du   +5 more
doaj   +1 more source

SYNTHESIS AND REACTIONS OF 3-ALKOXY-2H-AZIRINES

, 1986
3-Alkoxy-2H-azirines 4 have been prepared by treatment of enol ethers 6 with iodine azide followed by base-catalysed elimination of HI and thermolysis of the resulting vinyl azide 5.
Rivera, M., SAINTE, F, BERNARDHENRIET, C, Gouverneur, V, Gouverneur, Veronique, Ghosez, Léon, GHOSEZ, L, RIVERA, M, Sainte, Francy, Bernard-Henriet, Christiane   +9 more
core   +1 more source

Strain Release of 1‐Azabicyclo[1.1.0]butanes as a Gateway to Highly Functionalized Azetidines: New Strategies and Structural Motifs

Chemistry – A European Journal, EarlyView.
Over the past decade, the interest in azetidines has continuously risen, by virtue of their highly appealing pharmaceutical properties. Monocyclic, spirocyclic, and bridged azetidines can be accessed by leveraging 1‐azabicyclo[1.1.0]butanes as precursors.
Yuri Gelato, Philipp Natho, Marco Colella, Renzo Luisi   +3 more
wiley   +1 more source

Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction

Molecules, 2015
The synthesis and reactivity of tetrazol-5-yl-phosphorus ylides towards N-halosuccinimide/TMSN3 reagent systems was explored, opening the way to new haloazidoalkenes bearing a tetrazol-5-yl substituent.
Ana L. Cardoso, Carmo Sousa, Marta S. C. Henriques, José A. Paixão, Teresa M. V. D. Pinho e Melo   +4 more
doaj   +1 more source