Results 51 to 60 of about 1,276 (179)
Beilstein Journal of Organic Chemistry, 2018 The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO ...
Jiyun Sun +5 more
doaj +1 more source
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
The Neber Approach to 2‑(Tetrazol-5-yl)‑2H‑Azirines
, 2016 The synthesis of 2-(tetrazol-5-yl)-2H-azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2H-azirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3 ...
Teresa M. V. D. Pinho e Melo (1724932) +4 more
core +1 more source
Synthesis of New 2-Halo-2-(1H-tetrazol-5-yl)-2H-azirines via a Non-Classical Wittig Reaction
Molecules, 2015 The synthesis and reactivity of tetrazol-5-yl-phosphorus ylides towards N-halosuccinimide/TMSN3 reagent systems was explored, opening the way to new haloazidoalkenes bearing a tetrazol-5-yl substituent.
Ana L. Cardoso +4 more
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Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.Thiolane sulfoximines provide practical and safer surrogates for hazardous azides in nitrene photochemistry, enabling direct access to 7,8‐diaminoquinolines and fused δ‐lactams. DFT calculations support the reaction mechanism and rationalize product selectivity.
Lorenzo Serusi +5 more
wiley +1 more source
SYNTHESIS AND REACTIONS OF 3-ALKOXY-2H-AZIRINES
, 1986 3-Alkoxy-2H-azirines 4 have been prepared by treatment of enol ethers 6 with iodine azide followed by base-catalysed elimination of HI and thermolysis of the resulting vinyl azide 5.
Rivera, M. +9 more
core +1 more source
Selective N‐Functionalization of Pyrazoles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek +2 more
wiley +1 more source
Pyridonderivate aus 3-Amino-2H-azirinen und Cyclopropenonen
CHIMIA, 1978 Reaction of the 3-dimethylamino-2H-azirines 1a and 1b with diphenylcyclopropenone (2a) in ether or acetonitrile leads to the 2-dimethylamino-5,6-diphenyl-4(3H)-pyridones 3a and 3b in 70 and 80% yield, respectively. The structure of these 1:1-adducts has
Stanislav Chaloupka, Heinz Heimgartner
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Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Chiral Pyrazolinylidene Complexes for Asymmetric Catalysis
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.The synthesis and application of pyrazolin‐5‐ylidene NHC chiral‐at‐ruthenium catalysts is reported. The strong donating pyrazolin‐5‐ylidene ligands led to highly electron rich ruthenium complexes, which showed excellent catalytic activity and enantioselectivity in the intramolecular aziridination of an alkene.
Felix Möller +6 more
wiley +1 more source