Results 51 to 60 of about 1,229 (176)

Synthesis of trifluoromethylated 2H-azirines through Togni reagent-mediated trifluoromethylation followed by PhIO-mediated azirination

Beilstein Journal of Organic Chemistry, 2018
The reaction of enamine compounds with the Togni reagent in the presence of CuI afforded β-trifluoromethylated enamine intermediates, which were converted directly to biologically interesting trifluoromethylated 2H-azirines by an iodosobenzene (PhIO ...
Jiyun Sun, Xiaohua Zhen, Huaibin Ge, Guangtao Zhang, Xuechan An, Yunfei Du   +5 more
doaj   +1 more source

Hj‐aggregates of quinoline‐fused boron‐dipyrromethene nanoparticles for near‐infrared dualmodal photodynamic and photothermal therapy

Smart Molecules, EarlyView.
A novel quinoline‐fused cyclic pyrrole is synthesized via lithium diisopropylamide‐catalyzed [3 + 2] cyclization, enabling the construction of a symmetrical boron‐dipyrromethene photosensitizer that forms Hj‐aggregates upon nanoparticle encapsulation.
Bo Zhang, Chuang Du, Yuewen Yang, Dongping Xu, Xin‐Dong Jiang, Hui‐Xin Liu, Gaowu Qin   +6 more
wiley   +1 more source

SYNTHESIS AND REACTIONS OF 3-ALKOXY-2H-AZIRINES

, 1986
3-Alkoxy-2H-azirines 4 have been prepared by treatment of enol ethers 6 with iodine azide followed by base-catalysed elimination of HI and thermolysis of the resulting vinyl azide 5.
Rivera, M., SAINTE, F, BERNARDHENRIET, C, Gouverneur, V, Gouverneur, Veronique, Ghosez, Léon, GHOSEZ, L, RIVERA, M, Sainte, Francy, Bernard-Henriet, Christiane   +9 more
core   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

The Neber Approach to 2‑(Tetrazol-5-yl)‑2H‑Azirines

, 2016
The synthesis of 2-(tetra­zol-5-yl)-2H-azirines is reported for the first time. Using the Neber approach, β-ketoxime-1H-tetrazoles were converted into the target 2H-azirines bearing phenyl, furan-2-yl, thiophen-2-yl, or pyrrol-2-yl substituents at C-3 ...
Teresa M. V. D. Pinho e Melo (1724932), Ana Lúcia Cardoso (1933843), Américo Lemos (1724944), Francisco Palacios (1447132), Lourdes Gimeno (1933846)   +4 more
core   +1 more source

Pyridonderivate aus 3-Amino-2H-azirinen und Cyclopropenonen

CHIMIA, 1978
Reaction of the 3-dimethylamino-2H-azirines 1a and 1b with diphenylcyclopropenone (2a) in ether or acetonitrile leads to the 2-dimethylamino-5,6-diphenyl-4(3H)-pyridones 3a and 3b in 70 and 80% yield, respectively. The structure of these 1:1-adducts has
Stanislav Chaloupka, Heinz Heimgartner
doaj   +1 more source

Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 Human Lung Adenocarcinoma Cells

Molecules, 2020
This work reports a straightforward regioselective synthetic methodology to prepare α-aminophosphine oxides and phosphonates through the addition of oxygen and sulfur nucleophiles to the C–N double bond of 2H-azirine derivatives. Determined by the nature
Victor Carramiñana, Ana M. Ochoa de Retana, Francisco Palacios, Jesús M. de los Santos   +3 more
doaj   +1 more source

Photochemistry of N‐Substituted, N′‐Tosyl Diphenyl Sulfondiimines

Journal of Physical Organic Chemistry, Volume 39, Issue 8, August 2026.
The irradiation of N‐substituted, N′‐tosyl diphenyl sulfondiimines with UV light induces the sequential photorelease of two different nitrenes. ABSTRACT Sulfondiimines are an emerging sulfur(VI) functional group with increasing use in synthesis and medicinal chemistry, yet their photochemical behavior has remained largely unexplored.
Bashar Aziz, Paul Danyi, John P. Carney, Ryan D. McCulla   +3 more
wiley   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source