Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs
European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar +7 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 The reaction of α-azidochalcones with carboxylic acids has been investigated resulting in the formation of α-amido-1,3-diketones under microwave irradiation via in situ formation of 2H-azirine intermediates.
Kandasamy Rajaguru +4 more
doaj +1 more source
Azirines. III. The Preparation of Azirine Derivatives by the Base-Catalyzed Rearrangement of Quaternary Hydrazones [PDF]
Bulletin of the Chemical Society of Japan, 1968 Abstract An attempt to prepare azirines by the base-catalyzed rearrangement of some quaternary hydrazones gave the corresponding azirine derivatives. Namely, 2-phenyl-3-methylazirine was obtained by the treatment of propiophenone dimethylhydrazone methiodide with potassium t-butoxide, but treatment with sodium isopropoxide gave 2,5 ...
openaire +1 more source
Selective Synthesis of N-Unsubstituted and N-Arylindoles by the Reaction of Arynes with Azirines
, 2016 The transition-metal-free and temperature-dependent highly selective reaction of arynes with 2H-azirines allowing the synthesis of either N-unsubstituted or N-arylindoles has been developed.
Thangaraj, Manikandan +4 more
core +1 more source
Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H‑Azirines”
, 2018 Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H ...
Luc Van Meervelt (1501579) +2 more
core +1 more source
New syntheses of aziridines and azirines.
, 1970 The work presented in this thesis concerns the oxidation of N-amino compounds and the interception of the reactive intermediates, the postulated amino-nitrenes. The Introduction has been divided into three parts concerning (1) the synthesis of aziridines
David John. Anderson (7700939)
core
Transition-metal-free synthesis of substituted pyridines via ring expansion of 2-allyl-2H-azirines
, 2014 A new strategy to open the 2-allyl-2H-azirines by 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) promotion in metal-free conditions affording 1-azatrienes that in situ electrocyclize to the pyridines in good to excellent yields is reported.
Loh, Teck-Peng +5 more
core +1 more source
2H-azirines en milieu acide formation et reactivite d'α-iminocarbeniums
, 1986 International audienceReactivity of protonated azirines is studied in solution and by chemical ionisation in the gazeous phase. Azirinium ion produces an α -iminocarbenium ; its reactivity is studied.
S. Lacombe +11 more
core +1 more source
Simple Asymmetric Synthesis of 2H-Azirines Derived from Phosphine Oxides†
, 2016 Simple Asymmetric Synthesis of 2H-Azirines Derived from Phosphine Oxides†
Jose Maria Ezpeleta (3049005) +3 more
core +1 more source
Continuous-Flow Synthesis of 2H-Azirines and Their Diastereoselective Transformation to Aziridines
, 2016 Using continuous-flow techniques, a small collection of 2H-azirines was prepared from oxime precursors via mesylation and base-promoted cyclisation. The 2H-azirines were either isolated after in-line purification or derivatised into a selection of 2 ...
Baxendale, Ian R., Baumann, Marcus
core +1 more source