Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]
, 2014 BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M. +3 more
core +1 more source
Low‐Energy Electron‐Induced Dissociation of the Radiosensitizing Agent Sanazole
ChemPlusChem, EarlyView.Employing mass spectrometry supported by quantum chemical calculations, electron attachment to gas‐phase and microhydrated sanazole, a hypoxic radiosensitizer, is examined. The results suggest that hydration closes and/or slows down the dissociation process and indicates that the initial mechanism of action in a reductive cell environment may be ...
Farhad Izadi +5 more
wiley +1 more source
High-Pressure Synthesis of a Pentazolate Salt [PDF]
arXiv, 2016 The pentazolates, the last all-nitrogen members of the azole series, have been notoriously elusive for the last hundred years despite enormous efforts to make these compounds in either gas or condensed phases. Here we report a successful synthesis of a solid state compound consisting of isolated pentazolate anions N5-, which is achieved by compressing ...
arxiv
Pharmacists' views on the implementation of therapeutic drug monitoring in oncology
Journal of Pharmacy Practice and Research, EarlyView.Abstract Background There is increasing interest in the potential benefit of therapeutic drug monitoring (TDM) in oncology. However, uptake in Australian hospitals is limited. Aim This study sought to explore hospital pharmacists' experiences with TDM in oncology, seeking to determine if they could provide insights into barriers and facilitators to its
Jane E. Carland +3 more
wiley +1 more source
Photoinduced Copper‐Catalyzed Cross‐Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay
Advanced ScienceThe transition metal‐catalyzed direct coupling reactions involving electron‐rich Fischer carbene species are largely underdeveloped and remain a big challenge.
Long Zheng +3 more
doaj +1 more source
Adhesive Properties and Sensitivity to Antifungal Drugs of Candida Albicans, Which Are Released From Patients of Gastroenterological Profile with Candidiasis of the Mucosa of the Upper Part of the Digestive Tract [PDF]
, 2016 Candida albicans were released from 146 loci from 89 patients in order to perform the investigation. The fourth stage of contamination by Candida albicans in the scrape from the tongue and candidiasis of the esophagus or /and the stomach during ...
Kushnirenko, I. (Inessa)
core +2 more sources
American International Journal of Biology and Life Sciences, 2019 Azoles are one of a cyclic derivatives of chemical heterocyclic chemical and organic compounds including g a five member di unsaturated ring structure composed of bi nitrogen atoms at position (3 and 4) and one sulfur atom at position (1). Most of prepared work
openaire +2 more sources
Azole-Resistant Aspergillosis: Epidemiology, Molecular Mechanisms, and Treatment.
Journal of Infectious Diseases, 2017 Aspergillus fumigatus remains the most common species in all pulmonary syndromes, followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis, postoperative aspergillosis and fungal keratitis.
A. Chowdhary, C. Sharma, J. Meis
semanticscholar +1 more source
Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models [PDF]
, 2017 Burkholderia cenocepacia is an opportunistic pathogen responsible for life-threatening infections in cystic fibrosis patients. B. cenocepacia is extremely resistant towards antibiotics and therapy is complicated by its ability to form biofilms.
Brackman, Gilles +10 more
core +7 more sources
Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity [PDF]
, 2018 Inactivation of sterol Δ5,6-desaturase (Erg3p) in the prevalent fungal pathogen Candida albicans is one of several mechanisms that can confer resistance to the azole antifungal drugs.
Alspaugh, J. Andrew +10 more
core +2 more sources