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The impact of azole resistance on aspergillosis guidelines
Annals of the New York Academy of Sciences, 2012Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A.
Sarah P, Georgiadou +1 more
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Azole resistance in Aspergillus fumigatus- comprehensive review
Archives of MicrobiologyAspergillus fumigatus is a ubiquitous filamentous fungus commonly found in the environment. It is also an opportunistic human pathogen known to cause a range of respiratory infections, such as invasive aspergillosis, particularly in immunocompromised individuals.
Mthokozisi, Dladla +3 more
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Molecular aspects of azole antifungal action and resistance
Drug Resistance Updates, 1999During the past three decades azole compounds have been developed as medical and agricultural agents to combat fungal diseases. During the 1980s they were introduced as orally active compounds in medicine and the number of such azole drugs is likely to expand in the near future.
David, Lamb, Diane, Kelly, Steven, Kelly
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Resistance of yeasts to azole-derivative antifungals
Journal of Antimicrobial Chemotherapy, 1993There are relatively few antifungal agents available for the treatment of systemic mycoses. The incidence of these infections, particularly among the immunocompromised, has increased significantly in recent years. Amphotericin B, flucytosine and the azole-derivatives--fluconazole, itraconazole and ketoconazole--are the only drugs of value in the ...
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Resistance to Azole Drugs in Neurospora crassa
Experimental Mycology, 1995Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 microgram/ml), fluconazole (MIC 5 micrograms/ml), and SCH39304 (MIC 5 micrograms/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not
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The rapid emergence of antifungal-resistant human-pathogenic fungi
Nature Reviews Microbiology, 2023Shawn R Lockhart, Jeremy A W Gold
exaly
A robust Th-azole framework for highly efficient purification of C2H4 from a C2H4/C2H2/C2H6 mixture
Nature Communications, 2020Xiao-Hong Xiong +2 more
exaly
Multi-azole resistance in aspergillus
European Infectious Disease, 2011Azole resistance in Aspergillus has emerged since 2007, especially in northern Europe. Patients with untreatable infection are becoming more frequent. The link between azole fungicides in agriculture is compelling, but not proven. Environmental isolates which are resistant tend to have one marker mutation, whereas isolates arising during therapy have ...
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