Results 31 to 40 of about 29,974 (187)

Genomic Context of Azole Resistance Mutations in Aspergillus fumigatus Determined Using Whole-Genome Sequencing. [PDF]

, 2015
A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene ...
Abdolrasouli, Alireza, Armstrong-James, Darius, Beale, Mathew A., Chowdhary, Anuradha, Fisher, Matthew C., Hagen, Ferry, Meis, Jacques F., Rhodes, Johanna, Rogers, Thomas R., Taylor, John W.   +9 more
core   +2 more sources

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

PLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant, Katie J. Field, J. Brett Sallach, Sara Moeskjær, Alex Williams, Laura J. Carter   +5 more
wiley   +1 more source

Prevalence of QoI resistance and mtDNA diversity in the Irish Zymoseptoria tritici population [PDF]

, 2019
peer-reviewedThe emergence and spread of Quinone outside Inhibitor (QoI) fungicide resistance in the Irish Zymoseptoria tritici population in the early 2000s had immediate impacts on the efficacy of the entire group of fungicides for the control of ...
Bucar, D.E., Hutton, F., Kildea, Steven, Phelan, S., Rosa, S. de la, Welch, T.E.   +5 more
core   +1 more source

The Lipid Composition of Azole-sensitive and Azole-resistant Strains of Candida albicans [PDF]

Microbiology, 1986
The lipid compositions of two azole-sensitive (A and B2630) and two azole-resistant (AD and KB) strains of the opportunistic fungal pathogen Candida albicans were studied by using several lipid extraction procedures: no differences were observed between the lipid content or total phospholipid/neutral lipid ratios of the four strains.
C A, Hitchcock, K J, Barrett-Bee, N J, Russell   +2 more
openaire   +2 more sources

An integrated social and natural sciences case study for the reuse of organic wastes as soil amendments

PLANTS, PEOPLE, PLANET, EarlyView.
Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder, Jose‐Luis Fajardo‐Escoffié, Laura Carter, Emily K. Durant, Katie J. Field, John Nightingale, Brett Sallach, Andrea‐Lorena Garduño‐Jiménez   +7 more
wiley   +1 more source

Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae [PDF]

, 2017
Azole-resistant strains of Aspergillus fumigatus have been detected and the underlying molecular mechanisms of resistance characterized. Point mutations in the cyp51A gene have been proved to be related to azole resistance in A.
Alcazar-Fuoli, L., Cuenca-Estrella, M., Mellado, E., Sanglard, D.   +3 more
core  

Creation and assessment of a clinical predictive calculator and mortality associated with Candida krusei bloodstream infections [PDF]

, 2018
Background Candida krusei bloodstream infection (CK BSI) is associated with high mortality, but whether this is due to underlying comorbidities in affected patients or the organism itself is unknown.
Hsueh, Kevin, Kronen, Ryan, Lin, Charlotte, Powderly, William G, Spec, Andrej   +4 more
core   +2 more sources

[Azole-resistant invasive aspergillosis].

Nederlands tijdschrift voor geneeskunde, 2009
Contains fulltext : 79815.pdf (Publisher’s version ) (Open Access)
Linden, J.W.M. van der, Warris, A., Meer, J.W.M. van der, Bresters, D., Melchers, W.J.G., Verweij, P.E.   +5 more
openaire   +3 more sources

Contaminants of emerging concern in agricultural soils: Current understanding, overlooked issues, and future priorities

PLANTS, PEOPLE, PLANET, EarlyView.
Contaminants of emerging concern (CECs) in agriculture represent a growing global challenge for food safety and public health. In this review, we synthesized evidence on how substances such as pharmaceuticals, microplastics, and per‐ and polyfluoroalkyl substances (PFAS) enter soils, accumulate in crops, and affect ecological and human health. We found
Laura J. Carter, Evyatar Ben Mordechay, Benny Chefetz, Zeyou Chen, Xinyi Cui, Jay Gan, Hui Li, Audrey Moores, Xiaoyu Gao   +8 more
wiley   +1 more source