Results 81 to 90 of about 29,974 (187)

Azole-resistant Aspergillus fumigatus in the Italian environment

Journal of Global Antimicrobial Resistance, 2019
Azole resistance in Aspergillus fumigatus environmental and clinical isolates is recognised as an emerging problem worldwide. Development of azole resistance may be environmentally driven because of the massive use of azole fungicides in agriculture. The mechanism of azole resistance is mostly related to mutations in the cyp51A gene.A.
Prigitano, Anna, Esposto, Maria C, Romanò, Luisa, Auxilia, Francesco, Tortorano, Anna M   +4 more
openaire   +3 more sources

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K. Patton, Radhika R. Narla, Dina N. Greene, Alson K. Burke, Elizabeth Micks, Mary F. Hebert, Lauren R. Cirrincione   +9 more
wiley   +1 more source

Emergence of Candida (Candidozyma) auris in Minas Gerais, Brazil: Genomic Surveillance to Guide Rapid Public Health Responses

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Candida (Candidozyma) auris is an emerging yeast that poses a significant global health threat due to its multidrug resistance and ability to cause healthcare‐associated outbreaks. Genomic surveillance is essential for monitoring spread, transmission and antifungal resistance.
Luiz Marcelo Ribeiro Tomé, Dhian Renato Almeida Camargo, Rafael Wesley Bastos, Sara Cândida Ferreira dos Santos, Natália Rocha Guimarães, Sílvia Helena Sousa Pietra Pedroso, Paulo Eduardo de Souza da Silva, Aristóteles Góes‐Neto, Lida Jouca de Assis Figueredo, Gabriella da Côrte Castro, Ana Maria Ribeiro Nunes Rodrigues, Flavia Ribeiro Soares Cruzeiro, Nádia Aparecida Campos Dutra, Josiane Barbosa Piedade Moura, Glauco de Carvalho Pereira, Carmem Dolores Faria, Marta Giovanetti, Felipe Campos de Melo Iani, Luiz Carlos Júnior Alcantara, Talita Émile Ribeiro Adelino   +19 more
wiley   +1 more source

Aspergillus Serology Predicts Relapse in Chronic Pulmonary Aspergillosis: Implications for Personalised Follow‐Up Strategies

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Introduction Relapses occur in up to 40% of patients after prolonged courses of antifungal treatment for chronic pulmonary aspergillosis (CPA). The factors predisposing to relapse remain poorly defined. Methods We conducted a retrospective study of adults treated for ≥ 6 months with oral azoles for CPA.
Annabel Choyce, Stefano Colombo, Cyrin Cyriac, Abdulrazaq Alasfour, Wai Kien Ng, Lauren Amphlett, Chris Kosmidis   +6 more
wiley   +1 more source

Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients [PDF]

, 2017
Objectives Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I) suffer from chronic candidosis caused mainly by Candida albicans, and repeated courses of azole antifungals have led to the development of resistance ...
Bowyer, Paul, Rautemaa, Riina, Richardson, Malcolm, Sanglard, Dominique, Saxen, Harri, Siikala, Emilia   +5 more
core  

Frequency of mutations associated with fungicide resistance and population structure of Mycosphaerella graminicola in Tunisia [PDF]

, 2018
The occurrence of fungicide resistance in Mycosphaerella graminicola populations from Tunisia was investigated by examining mutations known to be associated with strobilurin and azole resistance.
Boukef, Sameh, Brunner, Patrick, McDonald, Bruce, Rezgui, Salah, Yahyaoui, Amor   +4 more
core  

A Chinese warning: Terbinafine‐resistant Trichophyton indotineae, a global dermatological challenge

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 148-149, February 2026.
Xin Zhou, Sybren de Hoog
wiley   +1 more source

Doxorubicin induces drug efflux pumps in Candida albicans [PDF]

, 2017
Candida albicans is one of the most important opportunistic fungal pathogens. It can cause serious fungal diseases in immunocompromised patients, including those with cancer. Treatment failures due to the emergence of drug-resistant C.
Coste, Alix T., Froelich, Daniela, Kofla, Grzegorz, Rognon, Bénédicte, Ruhnke, Markus, Sanglard, Dominique, Schulz, Bettina, Storch, Ulrike, Turner, Vincent   +8 more
core  

[Azole resistance in Candida albicans].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2001
The molecular mechanisms of azole resistance in Candida albicans include alterations in the target enzyme (lanosterol 14-demethylase) and overexpression of efflux transporters that decrease the intracellular concentration of the drug. Although the rate of azole resistance in systemic isolates of C.
openaire   +1 more source

Azole drug resistance in Candida species [PDF]

Journal of Medical Microbiology, 1992
openaire   +2 more sources