Results 21 to 30 of about 21,150 (298)
World Journal of Gastroenterology, 2020 BACKGROUND Colitis-associated cancer (CAC) accounts for 2%-3% of colorectal cancer (CRC) cases preceded by inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. Intestinal microbiota has been reported to play a central role in
D. Silveira +5 more
semanticscholar +1 more source
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate [PDF]
Molecular Carcinogenesis, 2015 The association between inflammation and the risk of colorectal cancer (CRC) is well documented in animal models and in humans, but the mechanistic role of inflammation in CRC is less well understood. To address this question, the induction of colon tumors was evaluated in (i) wild type (WT) and athymic BALB/c mice treated with the colon carcinogen ...
Whetstone, Ryan D. +4 more
openaire +3 more sources
International Journal of Molecular Sciences, 2020 Type 2 diabetes mellitus and its related insulin resistance are known to increase the risk of cancer. Anti-diabetic agents can improve insulin resistance and may lead to the suppression of carcinogenesis.
J. Kato +6 more
semanticscholar +1 more source
Role of Hepatic and Intestinal P450 Enzymes in the Metabolic Activation of the Colon Carcinogen Azoxymethane in Mice [PDF]
Chemical Research in Toxicology, 2014 P450-mediated bioactivation of azoxymethane (AOM), a colon carcinogen, leads to the formation of DNA adducts, of which O6-methylguanine (O6-mG) is the most mutagenic and contributes to colon tumorigenesis.
Vandana Megaraj +5 more
openalex +2 more sources
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis
mSphere, 2016 There is growing evidence that individuals with colonic adenomas and carcinomas harbor a distinct microbiota. Alterations to the gut microbiota may allow the outgrowth of bacterial populations that induce genomic mutations or exacerbate tumor-promoting ...
Joseph P. Zackular +3 more
doaj +1 more source
Dehydroalanine and Lysinoalanine in Thermolyzed Casein do not Promote Colon Cancer in the Rat [PDF]
, 2008 Thermolysis of proteins produces xenobiotic amino-acids such as the potentially toxic lysinoalanine, and the alkylating agent, dehydro¬alanine, which have been considered possible health hazards.
AIN +36 more
core +3 more sources
Chemoprevention of aberrant crypt foci in the colon of rats by dietary onion [PDF]
, 2007 Onion intake might reduce the risk of colorectal cancer, according to epidemiology. However, Femia showed in 2003 that diets with a 20% onion intake increase carcinogenesis in rats. We speculated this dose was too high.
Corpet, Denis E. +2 more
core +4 more sources
American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
Journal of Ginseng Research, 2015 Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice ...
Chunhao Yu +9 more
doaj +1 more source
Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved [PDF]
, 2011 Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer ...
Bingham +24 more
core +4 more sources