Results 31 to 40 of about 645,096 (154)

The role of laboratory biomarkers in monitoring of rituximab biosimilar therapy (Acellbia, “BIOCAD”) in patients with rheumatoid arthritis [PDF]

Терапевтический архив, 2019
Aim: to evaluate the role of laboratory biomarkers in monitoring effectiveness of rituximab (RTM) biosimilar therapy in a total dose of 1200 mg. Materials and methods.
A S Avdeeva, M V Cherkasova, D A Kusevich, V V Rybakova, A S Artyuhov, Eh B Dashinimaev, N V Chichasova, E L Nasonov   +7 more
doaj   +1 more source

The Architecture of Idiotypic Networks: Percolation and Scaling Behaviour [PDF]

, 2000
We investigate a model where idiotypes (characterizing B-lymphocytes and antibodies of an immune system) and anti-idiotypes are represented by complementary bitstrings of a given length d allowing for a number of mismatches (matching rules). In this model, the vertices of the hypercube in dimension d represent the potential repertoire of idiotypes.
arxiv   +1 more source

T and B cell responses in different immunization scenarios for COVID-19: a narrative review

Frontiers in Immunology
Vaccines against COVID-19 have high efficacy and low rates of adverse events. However, none of the available vaccines provide sterilizing immunity, and reinfections remain possible.
Eva Piano Mortari, Francesca Ferrucci, Irini Zografaki, Rita Carsetti, Luciano Pacelli   +4 more
doaj   +1 more source

Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases

Case Reports in Nephrology and Dialysis, 2022
Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy
Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza   +2 more
doaj   +1 more source

Changes in leukocyte counts, lymphocyte subpopulations and the mRNA expression of selected cytokines in the peripheral blood of dogs with atopic dermatitis

Veterinární Medicína, 2015
Canine atopic dermatitis (CAD) is a chronic allergic disease characterised by genetic predisposition. The exact pathogenesis of the disease is still not fully understood. Blood parameters, lymphocyte subpopulations, cytokines and other molecules involved
Z. Hoskova, M. Svoboda, D. Satinska, J. Matiasovic, L. Leva, M. Toman   +5 more
doaj   +1 more source

Pathogenesis-based treatments in primary Sjogren's syndrome using artificial intelligence and advanced machine learning techniques: a systematic literature review

Human Vaccines & Immunotherapeutics, 2018
Big data analysis has become a common way to extract information from complex and large datasets among most scientific domains. This approach is now used to study large cohorts of patients in medicine. This work is a review of publications that have used
Nathan Foulquier, Pascal Redou, Christophe Le Gal, Bénédicte Rouvière, Jacques-Olivier Pers, Alain Saraux   +5 more
doaj   +1 more source

HLA-DR expression in melanoma: from misleading therapeutic target to potential immunotherapy biomarker

Frontiers in Immunology
Since the advent of anti-PD1 immune checkpoint inhibitor (ICI) immunotherapy, cutaneous melanoma has undergone a true revolution with prolonged survival, as available 5-year updates for progression-free survival and overall survival demonstrate a durable
Karim Amrane, Karim Amrane, Coline Le Meur, Benjamin Besse, Benjamin Besse, Patrice Hemon, Pierre Le Noac’h, Pierre Le Noac’h, Olivier Pradier, Christian Berthou, Christian Berthou, Ronan Abgral, Ronan Abgral, Arnaud Uguen, Arnaud Uguen   +14 more
doaj   +1 more source

Evolution and phylogeny of B lymphocytes

Revista Alergia México, 2016
B lymphocytes are one of the most important cell types involved in the immune response of mammals. The origin and evolution of this cellular type is unknown, but the B lymphocyte bona fide appeared first in fish.
Fabiola Claudio-Piedras, Humberto Lanz-Mendoza   +1 more
doaj   +1 more source

Characterization of Immunogenic and Protective Properties of the Modified Variants of the Strain Francisella tularensis 15 NIIEG

Проблемы особо опасных инфекций, 2020
Francisella tularensis is an intracellular bacterium that causes tularemia. Progress in creating a safe and effective vaccine for the prevention of tularemia is challenging due to a lack of knowledge about immunological parameters indicative of ...
A. S. Kartseva, O. V. Kalmantaeva, M. V. Silkina, T. I. Kombarova, V. M. Pavlov, A. N. Mokrievich, V. V. Firstova   +6 more
doaj   +1 more source

Mathematical modeling of lymphocytes selection in the germinal center [PDF]

arXiv, 2015
Lymphocyte selection is a fundamental operation of adaptive immunity. In order to produce B-lymphocytes with a desired antigenic profile, a process of mutation-selection occurs in the germinal center, which is part of the lymph nodes. We introduce in this article a simplified mathematical model of this process, taking into account the main mechanisms ...
arxiv