Results 31 to 40 of about 14,976,308 (290)

CD4+ T cells reverse surface antigen persistence in a mouse model of HBV replication

Microbiology Spectrum, 2023
Hepatitis B virus (HBV) is responsible for over 800,000 deaths yearly worldwide. While chronic HBV infection currently has no highly effective cure, immunotherapy has generated interest as a potential therapeutic solution due to the connection between ...
Jacob T. Bailey, Safiehkhatoon Moshkani, Catherine Rexhouse, Jesse L. Cimino, Michael D. Robek   +4 more
doaj   +1 more source

Comparison of 2002 AECG and 2016 ACR/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sjögren’s syndrome

Arthritis Research & Therapy, 2017
Background The objective was to evaluate concordance between 2002 American-European Consensus Group (AECG) and 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for primary Sjögren’s syndrome ...
Maëlle Le Goff, Divi Cornec, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Rozenn Le Berre, Steeve Genestet, Béatrice Cochener, Sylvie Boisrame-Gastrin, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec   +13 more
doaj   +1 more source

B lymphocyte

Japanese Journal of Clinical Immunology, 2005
Recent studies have revealed that B cells play a critical role in autoimmunity and disease expression through various functions, including autoantibody production, cytokine secretion, antigen presentation, and co-stimulatory effect. Selective targeting of B cells has been recently achieved using a chimeric monoclonal antibody against CD20 (Rituximab ...
openaire   +3 more sources

Positive and negative functions of B lymphocytes in tumors

OncoTarget, 2016
Accumulating evidence indicated that B lymphocytes exerted complex functions in tumor immunity. On the one hand, B lymphocytes can inhibit tumor development through antibody generation, antigen presentation, tumor tissue interaction, and direct killing ...
Meng Shen, Qian Sun, Jian Wang, Wei Pan, X. Ren   +4 more
semanticscholar   +1 more source

Coupling imaging mass cytometry with Alcian blue histochemical staining for a single-slide approach

Frontiers in Immunology
Imaging mass cytometry (IMC) is a metal mass spectrometry-based method allowing highly multiplex immunophenotyping of cells within tissue samples. However, some limitations of IMC are its 1-µm resolution and its time and costs of analysis limiting ...
Patrice Hemon, Danivanh Ben-Guigui, Margaux Geier, Margaux Geier, Marine Castillon, Marine Castillon, Corentin Paranthoen, Corentin Paranthoen, Jacques-Olivier Pers, Marion Le Rochais, Arnaud Uguen, Arnaud Uguen   +11 more
doaj   +1 more source

B‐lymphocyte calcium inFlux [PDF]

Immunological Reviews, 2009
Summary:  Dynamic changes in cytoplasmic calcium concentration dictate the immunological fate and functions of lymphocytes. During the past few years, important details have been revealed about the mechanism of store‐operated calcium entry in lymphocytes, including the molecular identity of calcium release‐activated calcium (CRAC) channels and the ...
Leslie B, King, Bruce D, Freedman
openaire   +2 more sources

B lymphocytes in neuromyelitis optica

Neurology: Neuroimmunology & Neuroinflammation, 2015
Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water ...
J. Bennett, K. O’Connor, A. Bar-Or, S. Zamvil, B. Hemmer, T. Tedder, H.-Christian von Büdingen, O. Stuve, M. Yeaman, Terry J. Smith, C. Stadelmann   +10 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Rituximab, Mycophenolic Acid, and Calcineurin Inhibitors Achieve Long-Term Remission in Pediatric Focal Segmental Glomerulosclerosis with Steroid-Resistant and Frequently Relapsing Nephrotic Syndrome: A Report of Two Cases

Case Reports in Nephrology and Dialysis, 2022
Studies investigating the effect of rituximab in children with nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS) have reported conflicting results, with some concluding that patients may require additional immunosuppressive therapy
Cahyani Gita Ambarsari, Meilania Saraswati, Genta Syaifrin Laudza   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source