Results 91 to 100 of about 26,900 (231)

Inhibitory effects of different fractions of Nepeta satureioides on melanin synthesis through reducing oxidative stress

Research in Pharmaceutical Sciences, 2017
Nepeta satureioides Boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. The aim of this study was to evaluate the effect of methanol (MeOH), n-hexane and dichloromethane (CH2Cl2) fractions of the ...
Seyed Ahmad Emami, Rezvan Yazdian-Robati, Mohammad Sadeghi, Javad Baharara, Elaheh Amini, Farzaneh Salek, Zahra Tayarani-Najaran   +6 more
doaj   +1 more source

The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration

Stem Cells International, 2020
There is still a lively debate about whether mesenchymal stem cells (MSCs) promote or suppress antitumor immune response. Although several possible explanations have been proposed, including different numbers of injected and engrafted MSCs, heterogeneity
Dragana Miloradovic, Dragica Miloradovic, Bojana Simovic Markovic, Aleksandar Acovic, Carl Randall Harrell, Valentin Djonov, Nebojsa Arsenijevic, Vladislav Volarevic   +7 more
doaj   +1 more source

Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor [PDF]

, 2014
Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs ...
Al-Hassani, Mohammed, Althouse, Sandra K., Ferracini, Matheus, Harrison, Kathleen A., Konger, Raymond L., Loesch, Mathew, Murphy, Robert C., Ocana, Jesus A., Perkins, Susan M., Sahu, Ravi P., Speicher, Paul J., Sun, Louis, Touloukian, Christopher E., Travers, Jeffrey B., Tyler, Douglas S.   +14 more
core   +1 more source

Improvement of protocol for detachment assays in B16F10 cells

GSC Biological and Pharmaceutical Sciences
B16F10 (B16) murine melanoma cells have the characteristic of strong adhesion to culture surfaces. The use of trypsin solutions in high doses to release this type of cell is not suitable. When B16F10 cells are released with high concentrations of trypsin they do not form a precipitate after centrifugation and consequently the cells will be lost when ...
Eric Almeida Xavier, Isabela Canavezzi Matias, Anelise Freitas Sandei   +2 more
openaire   +2 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Loss of adhesion impairs invasiveness and cell survival, contributing to the antimetastatic effect of cysteine proteases from Vasconcella cundinamarcensis in melanoma

Scientific Reports
Based on available evidence showing the antitumoral/antimetastatic activity of the proteolytic fraction (P1G10) from Vasconcellea cundinamarcensis, we analyze possible mechanisms involved in the antimetastasic effect of this fraction and subfractions ...
Dalton Dittz, Isabela Paula Nunes, Hortência Maciel de Castro Oliveira, Gustavo Batista de Menezes, Carlos Edmundo Salas Bravo, Miriam Teresa Paz Lopes   +5 more
doaj   +1 more source

Epidermal PPARγ influences subcutaneous tumor growth and acts through TNF-α to regulate contact hypersensitivity and the acute photoresponse [PDF]

, 2017
It is known that ultraviolet B (UVB) induces PPARγ ligand formation while loss of murine epidermal PPARγ (Pparg-/-epi) promotes UVB-induced apoptosis, inflammation, and carcinogenesis. PPARγ is known to suppress tumor necrosis factor-α (TNF-α) production.
Derr-Yellin, Ethel, Konger, Raymond L., Ocana, Jesus A., Sahu, Ravi P., Travers, Jeffrey B.   +4 more
core   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Hyperdifferentiated murine melanoma cells promote adaptive anti-tumor immunity but activate the immune checkpoint system

OncoImmunology
Accumulating evidence suggests that phenotype switching of cancer cells is essential for therapeutic resistance. However, the immunological characteristics of drug-induced phenotype-switching melanoma cells (PSMCs) are unknown.
Yukie Ando, Yutaka Horiuchi, Sara Hatazawa, Momo Mataki, Akihiro Nakamura, Takashi Murakami   +5 more
doaj   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source