Results 81 to 90 of about 26,900 (231)

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Decreasing Microtubule Actin Cross-Linking Factor 1 Inhibits Melanoma Metastasis by Decreasing Epithelial to Mesenchymal Transition

Cancer Management and Research, 2020
Xiaoying Wang, 1 Xiao Jian, 1 Jun Dou, 2 Zicheng Wei, 3 Fengshu Zhao 2 1Wuxi School of Medicine, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Pathogenic Biology and Immunology, School of Medicine, Southeast University ...
Wang X, Jian X, Dou J, Wei Z, Zhao F
doaj  

Acute and subacute (28 days) toxicity, hemolytic and cytotoxic effect of Artocarpus heterophyllus seed extracts

Toxicology Reports, 2019
Background: Plants and their parts are a part of life in many Brazilian communities, as observed in the jackfruit. The jackfruit seeds are consumed, usually, as roasted, boiled, steamed, and are eaten as a snack.
Lígia Moura Burci, Cristiane Bezerra da Silva, Josimara Nolasco Rondon, Luisa Mota da Silva, Sérgio Faloni de Andrade, Obdulio Gomes Miguel, Josiane de Fátima Gaspari Dias, Marilis Dallarmi Miguel   +7 more
doaj   +1 more source

Comparative Study of Curcumin and Its Hydrogenated Metabolites, Tetrahydrocurcumin, Hexahydrocurcumin, and Octahydrocurcumin, on Melanogenesis in B16F10 and MNT-1 Cells

Cosmetics, 2021
Curcumin, a bioactive from Curcuma longa, has been shown to possess anti-melanogenic activity previously; however, the effects of its hydrogenated metabolites (HMs)—Tetrahydrocurcumin (THC), Hexahydrocurcumin (HHC), and Octahydrocurcumin (OHC)—on ...
Shilpi Goenka, Sanford R. Simon
doaj   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Samsoeum, a traditional herbal medicine, elicits apoptotic and autophagic cell death by inhibiting Akt/mTOR and activating the JNK pathway in cancer cells [PDF]

, 2013
BACKGROUND: Samsoeum (SSE), a traditional herbal formula, has been widely used to treat cough, fever, congestion, and emesis for centuries. Recent studies have demonstrated that SSE retains potent pharmacological efficiency in anti-allergic and anti ...
Aeyung Kim, Jin Yeul Ma, Nam-Hui Yim
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

In vitro and in vivo anticancer properties of a Calcarea carbonica derivative complex (M8) treatment in a murine melanoma model [PDF]

, 2010
Background: Melanoma is the most aggressive form of skin cancer and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have had only marginal success.
Fernando SF Guimarães, Lucas F Andrade, Sharon T Martins, Ana PR Abud, Reginaldo V Sene, Carla Wanderer, Inés Tiscornia, Mariela Bollati-Fogolín, Dorly F Buchi, Edvaldo S Trindade, DS Rigel, JF Thompson, KS Smalley, I Satzger, KP Claffey, RD Sanderson, K Fjeldstad, PJ Bergman, MR Piemonte, CC Oliveira, CC Oliveira, IC Seligmann, DY Sato, AP Abud, B Cesar, FSF Guimaraes, M Bollati-Fogolín, W Zhao, P Dua, JT McConville, C Monteagudo, FSF Guimaraes, S Milazzo, MS Goldstein, EL Cooper, F Pascual-Carpe, S Es, JD Burton, MG Tucci, PA Ascierto, E Pikarsky, J Rivera, R Lotfi, X Jiang, X Jiang, BR Olsen, CS Smith   +46 more
core   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source