Results 61 to 70 of about 26,900 (231)

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system [PDF]

, 2013
OBJECTIVE: Available chemotherapy presents poor control over the development of metastatic melanoma. FTY720 is a compound already approved by the Food and Drug Administration for the treatment of patients with multiple sclerosis.
Arruda, Denise Costa, Bueno, Valquiria, Figueiredo, Carlos Rogerio, Massaoka, Mariana Hiromi, Matsuo, Alisson Leonardo, Pereira, Felipe Valença, Rodrigues, Elaine Guadelupe   +6 more
core   +5 more sources

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Antitumour responses induced by a cell-based Reovirus vaccine in murine lung and melanoma models [PDF]

, 2016
Background: The ever increasing knowledge in the areas of cell biology, the immune system and the mechanisms of cancer are allowing a new phase of immunotherapy to develop.
Campion, Ciorsdan A., Forde, Patrick F., Soden, Declan   +2 more
core   +1 more source

The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470 [PDF]

Cellular and Molecular Biology Letters, 2006
AbstractTNP-470 is an acknowledged anti-angiogenic factor, and was studied clinically as an anti-cancer drug. We previously reported on an additional property of this molecule: the intracellular generation of reactive oxygen species in B16F10 melanoma cells. We showed that a massive generation of ROS occurred in the first few hours after treatment with
Marcin, Okrój, Dorota, Stawikowska, Ewa M, Słomińska, Andrzej, Myśliwski, Jacek, Bigda   +4 more
openaire   +2 more sources

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells

OncoImmunology, 2018
The B16F10 murine melanoma cell line displays a low expression of MHC class I molecules favoring immune evasion and metastases in immunocompetent C57 BL/6 wild-type mice.
Friedrich Foerster, Sebastian Boegel, Rosario Heck, Geetha Pickert, Nina Rüssel, Sebastian Rosigkeit, Matthias Bros, Stephanie Strobl, Leonard Kaps, Misbah Aslam, Mustafa Diken, John Castle, Ugur Sahin, Andrea Tuettenberg, Ernesto Bockamp, Detlef Schuppan   +15 more
doaj   +1 more source

Soft corals collected from Jeju Island inhibits the α-MSH-induced melanogenesis in B16F10 cells through activation of ERK

Fisheries and Aquatic Sciences, 2018
In the present study, we first evaluated the melanin inhibitory effect of four crude 70% ethanol extracts separated from soft corals abundantly growing along the seawaters of Jeju Island, South Korea, including Dendronephthya castanea (DC ...
K. K. Asanka Sanjeewa, Young-jin Park, I. P. Shanura Fernando, Yong-Seok Ann, Chang-Ik Ko, Lei Wang, You-Jin Jeon, WonWoo Lee   +7 more
doaj   +1 more source

Radiation therapy generates platelet-activating factor agonists [PDF]

, 2016
Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R).
Chin-Sinex, Helen Jan, Dynlacht, Joseph R., Garrett, Joy Elizabeth, Harrison, Kathleen A., Johnston II., Michael Edward, Konger, Raymond L., Li, Gengxin, McMullen, Kevin, Mendonca, Marc, Murphy, Robert C., Sahu, Ravi P., Spandau, Dan F., Travers, Jeffrey B., Weyerbacher, Jonathan   +13 more
core   +2 more sources

Development of Nanoflare Nanosensors for Monitoring Cellular Insulin mRNA in Beta Cells and Islets

Advanced Materials Technologies, EarlyView.
This study presents the design and application of In2‐NF probes for detecting insulin mRNA in beta cells and islets. Using spherical nucleic acid‐coated gold nanoparticles, the probes offer strong fluorescent signals upon hybridization. Their performance is validated across 2D and 3D cultures and rat islets, demonstrating sensitive, real‐time mRNA ...
Yana Hu, Qizheng Zhang, Tianli Hu, Juewen Liu, Hongxing Fu, Xin Zhao, Zijiang Yang, Chenjie Xu   +7 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source