Results 41 to 50 of about 26,900 (231)

Role of Annexin A1 Secreted by Neutrophils in Melanoma Metastasis

Cells, 2023
Annexin A1 (AnxA1) is highly secreted by neutrophils and binds to formyl peptide receptors (FPRs) to trigger anti-inflammatory effects and efferocytosis. AnxA1 is also expressed in the tumor microenvironment, being mainly attributed to cancer cells.
Silvana Sandri, Cristina Bichels Hebeda, Milena Fronza Broering, Marina de Paula Silva, Luciana Facure Moredo, Milton José de Barros e Silva, André Sapata Molina, Clóvis Antônio Lopes Pinto, João Pedreira Duprat Neto, Chris P. Reutelingsperger, Cristiane Damas Gil, Sandra Helena Poliselli Farsky   +11 more
doaj   +1 more source

Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. [PDF]

, 2018
Regulatory T cells (Tregs) are critical for maintaining immune homeostasis, but their presence in tumor tissues impairs anti-tumor immunity and portends poor prognoses in cancer patients.
Abnousian, Arbi, Bluestone, Jeffrey A, DuPage, Michel, Fong, Lawrence, Harwin, Tory, Mahuron, Kelly, Pagani, Massimiliano, Pai, Chien-Chun, Quiros, Jason, Ranzani, Valeria, Rosenblum, Michael D, Silveria, Stephanie, Van Gool, Frederic, Wang, David, Young, Arabella   +14 more
core   +2 more sources

Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth

Molecular Cancer, 2007
Background Angiogenesis is a fundamental process that allows tumor growth by providing nutrients and oxygen to the tumor cells. Beyond the oxygen diffusion limit from a capillary blood vessel, tumor cells become apoptotic.
Juliano Luiz, Juliano Maria A, Monteiro Hugo P, Oliveira Vitor, Rodrigues Elaine G, Carmona Adriana K, Paschoalin Thaysa, Travassos Luiz R   +7 more
doaj   +1 more source

Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]

, 2017
Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo, Andrey Loboda, Ashani T. Weeraratna, Ayumi Hashimoto, Brian Nam, Butowski, Carus, Challacombe, Chao, Charles Mulligan, Chunsheng Zhang, Condamine, Conway, Coussens, David W. Speicher, DeNardo, Dmitry I. Gabrilovich, Douglas Marvel, Ellen Puré, Fang Wang, Fearon, Feig, Finke, Fred Denstman, Gabrilovich, Gabrilovich, Gascard, Genovese, Gentles, Greenberg, Grivennikov, Guleria, Huang, Kato, Kumar, Ladanyi, Laxminarasimha Donthireddy, Lin, Linda A. Snyder, Lo, Lokeshwar, Lucas, Lucia R. Languino, MacDonald, Manuel A. Sepulveda, Mao, Marlee A. Goins, Messmer, Meyer, Mishra, Mitchem, Mok, Mok, Neil Hockstein, Newman, Noman, Obermajer, Ohno, Orimo, Peter Ordentlich, Pixley, Prashanthi Vonteddu, Pyonteck, Qin Liu, Ramachandran, Reeti Behera, Ries, Ries, Robert H. Vonderheide, Sasse, Sergio Lavilla-Alonso, Shanti Shakamuri, Sionov, Sluijter, Solito, Strachan, Szkandera, Talmadge, Tap, Thomas Condamine, Timothy Chao, Vetsika, Vinit Kumar, Wang, Weber, Xiaowei Xu, Xu, Yang, Zhang, Zhang, Zhu   +90 more
core   +2 more sources

(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression.

PLoS ONE, 2015
We investigated the potential melanogenic effect of compounds from Zingiber cassumunar Roxb. Our data revealed that chloroform-soluble extract of Z. cassumunar enhanced melanin synthesis in B16F10 melanoma cells.
Jisu Park, Heesung Chung, Seung Hyun Bang, Ah-Reum Han, Eun-Kyoung Seo, Sung Eun Chang, Duk-Hee Kang, Eok-Soo Oh   +7 more
doaj   +1 more source

Photoprotection by dietary phenolics against melanogenesis induced by UVA through Nrf2-dependent antioxidant responses

Redox Biology, 2016
Dietary phenolics may play a protective role in UV-mediated skin pigmentation through their antioxidant and UV-absorbing actions. In this study, we investigated whether genetic silencing of Nrf2, regulating the transcription of antioxidant genes ...
Anyamanee Chaiprasongsuk, Tasanee Onkoksoong, Thanyawan Pluemsamran, Saowalak Limsaengurai, Uraiwan Panich   +4 more
doaj   +1 more source

Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors [PDF]

, 2013
Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy benzaldehyde ...
Abbasalipour, V., Fozooni, S., Hamidian, H., Namjou, M., Tagizadeh, R., Taheri, A.   +5 more
core   +1 more source

CAV1 inhibits metastatic potential in melanomas through suppression of the Integrin/Src/FAK signaling pathway. [PDF]

, 2010
Caveolin-1 (CAV1) is the main structural component of Caveolae which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events.
Aplin, Andrew E, Bonuccelli, Gloria, Capozza, Franco, Daumer, Kristin M, Lisanti, Michael P, Milliman, Janet N, Pestell, Richard G, Sotgia, Federica, Trimmer, Casey, Whitaker-Menezes, Diana   +9 more
core   +2 more sources

Effects of T-cadherin expression on B16F10 melanoma cells

Oncology Letters, 2013
Melanoma is one of the most deadly skin cancers. T-cadherin is an atypical member of the cadherin superfamily as it lacks the transmembrane and cytoplasmic domains and is anchored to cell membranes through glycosylphosphatidylinositol (GPI) anchors.
DUAN, XIN-SUO, LU, JIE, GE, ZHI-HUA, XING, EN-HONG, LU, HAI-TAO, SUN, LI-XIN   +5 more
openaire   +3 more sources

RETRACTED Overexpressed PKCδ downregulates the expression of PKCα in B16F10 melanoma: induction of apoptosis by PKCδ via ceramide generation.

PLoS ONE, 2014
In the present study, we observed a marked variation in the expression of PKCα and PKCδ isotypes in B16F10 melanoma tumor cells compared to the normal melanocytes.
Kuntal Halder, Sayantan Banerjee, Anamika Bose, Saikat Majumder, Subrata Majumdar   +4 more
doaj   +1 more source